Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Markus W Covert"'
Autor:
Christopher J Skalnik, Sean Y Cheah, Mica Y Yang, Mattheus B Wolff, Ryan K Spangler, Lee Talman, Jerry H Morrison, Shayn M Peirce, Eran Agmon, Markus W Covert
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011232 (2023)
Antibiotic resistance poses mounting risks to human health, as current antibiotics are losing efficacy against increasingly resistant pathogenic bacteria. Of particular concern is the emergence of multidrug-resistant strains, which has been rapid amo
Externí odkaz:
https://doaj.org/article/c586e70966d047e2adda5d4777ce5255
Autor:
David A Van Valen, Takamasa Kudo, Keara M Lane, Derek N Macklin, Nicolas T Quach, Mialy M DeFelice, Inbal Maayan, Yu Tanouchi, Euan A Ashley, Markus W Covert
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005177 (2016)
Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays in dynamic, living systems. A major critical challenge for this class of experiments is the problem of image segmentation, or determining which parts of a micr
Externí odkaz:
https://doaj.org/article/fbd13d77eb8040efa67c729bc11bb083
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-13 (2012)
Abstract Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal
Externí odkaz:
https://doaj.org/article/cfe3cb5670c24b3cbd0dfb770a5c8ba3
Autor:
Jonathan R Karr, Alex H Williams, Jeremy D Zucker, Andreas Raue, Bernhard Steiert, Jens Timmer, Clemens Kreutz, DREAM8 Parameter Estimation Challenge Consortium, Simon Wilkinson, Brandon A Allgood, Brian M Bot, Bruce R Hoff, Michael R Kellen, Markus W Covert, Gustavo A Stolovitzky, Pablo Meyer
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 5, p e1004096 (2015)
Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which
Externí odkaz:
https://doaj.org/article/2a2eb868df8148ecaf650daab711d510
Autor:
Miriam V Gutschow, Jacob J Hughey, Nicholas A Ruggero, Bryce T Bajar, Sean D Valle, Markus W Covert
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53222 (2013)
Lipopolysaccharide (LPS), found in the outer membrane of gram-negative bacteria, elicits a strong response from the transcription factor family Nuclear factor (NF)-κB via Toll-like receptor (TLR) 4. The cellular response to lipopolysaccharide varies
Externí odkaz:
https://doaj.org/article/c4e6e4c1301e4ef599c59a934258dd0b
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 10, p e1002746 (2012)
Viral replication relies on host metabolic machinery and precursors to produce large numbers of progeny - often very rapidly. A fundamental example is the infection of Escherichia coli by bacteriophage T7. The resource draw imposed by viral replicati
Externí odkaz:
https://doaj.org/article/6f42bebb8a6648b1ad921a6024d861c1
Autor:
Nathaniel D Maynard, Elsa W Birch, Jayodita C Sanghvi, Lu Chen, Miriam V Gutschow, Markus W Covert
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001017 (2010)
Latently infecting viruses are an important class of virus that plays a key role in viral evolution and human health. Here we report a genome-scale forward-genetics screen for host-dependencies of the latently-infecting bacteriophage lambda. This scr
Externí odkaz:
https://doaj.org/article/02685568cb664ee6981cabdde93f1dca
Autor:
Heejo Choi, Markus W Covert
Publikováno v:
Nucleic Acids Research.
In Escherichia coli, inconsistencies between in vitro tRNA aminoacylation measurements and in vivo protein synthesis demands were postulated almost 40 years ago, but have proven difficult to confirm. Whole-cell modeling can test whether a cell behave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e8c8c15cf839b06e6c22ef6ef73a10
https://doi.org/10.1093/nar/gkad435
https://doi.org/10.1093/nar/gkad435
Publikováno v:
J Biol Chem
Immune cells adopt a variety of metabolic states to support their many biological functions, which include fighting pathogens, removing tissue debris, and tissue remodeling. One of the key mediators of these metabolic changes is the transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f12be03241e1254a2b4a0ca7cf6f49
https://europepmc.org/articles/PMC10124923/
https://europepmc.org/articles/PMC10124923/
Publikováno v:
npj Systems Biology and Applications. 8
Growth and environmental responses are essential for living organisms to survive and adapt to constantly changing environments. In order to simulate new conditions and capture dynamic responses to environmental shifts in a developing whole-cell model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3a1d13f463dc2bce384924c883bea2
https://doi.org/10.1038/s41540-022-00242-9
https://doi.org/10.1038/s41540-022-00242-9