Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Markus W, Löffler"'
Autor:
Sandra Schwarz, Zhaoran Su, Mathias Krohn, Markus W. Löffler, Andreas Schlosser, Michael Linnebacher
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024)
Abstract Two hypermutated colon cancer cases with patient-derived cell lines, peripheral and tumor-infiltrating T cells available were selected for detailed investigation of immunological response. T cells co-cultured with autologous tumor cells show
Externí odkaz:
https://doaj.org/article/a35ac3559cdd4f6eb678fafa6699d0c6
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTCytotoxic T lymphocytes are key for controlling viral infection. Unravelling CD8+ T cell-mediated immunity to distinct influenza virus strains and subtypes across prominent HLA types is relevant for combating seasonal infections and emerging
Externí odkaz:
https://doaj.org/article/381264734ff34a789b289a2eb1c61cc3
Autor:
Jonas S. Heitmann, Claudia Tandler, Maddalena Marconato, Annika Nelde, Timorshah Habibzada, Susanne M. Rittig, Christian M. Tegeler, Yacine Maringer, Simon U. Jaeger, Monika Denk, Marion Richter, Melek T. Oezbek, Karl-Heinz Wiesmüller, Jens Bauer, Jonas Rieth, Marcel Wacker, Sarah M. Schroeder, Naomi Hoenisch Gravel, Jonas Scheid, Melanie Märklin, Annika Henrich, Boris Klimovich, Kim L. Clar, Martina Lutz, Samuel Holzmayer, Sebastian Hörber, Andreas Peter, Christoph Meisner, Imma Fischer, Markus W. Löffler, Caroline Anna Peuker, Stefan Habringer, Thorsten O. Goetze, Elke Jäger, Hans-Georg Rammensee, Helmut R. Salih, Juliane S. Walz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract T-cell immunity is central for control of COVID-19, particularly in patients incapable of mounting antibody responses. CoVac-1 is a peptide-based T-cell activator composed of SARS-CoV-2 epitopes with documented favorable safety profile and e
Externí odkaz:
https://doaj.org/article/b32dbe5fcabf453983d2e107f672acc4
Autor:
Can Yurttas, Philipp Horvath, Imma Fischer, Silvia Wagner, Karolin Thiel, Ruth Ladurner, Ingmar Königsrainer, Alfred Königsrainer, Matthias Schwab, Stefan Beckert, Markus W. Löffler
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 8, p 2422 (2024)
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This prospective
Externí odkaz:
https://doaj.org/article/e37563bfed594fb5b830bf4ea176b1e0
Autor:
Can Yurttas, Julia Beil, Susanne Berchtold, Irina Smirnow, Linus D. Kloker, Bence Sipos, Markus W. Löffler, Alfred Königsrainer, André L. Mihaljevic, Ulrich M. Lauer, Karolin Thiel
Publikováno v:
Cancers, Vol 16, Iss 2, p 368 (2024)
Effective treatment options for peritoneal surface malignancies (PSMs) are scarce. Oncolytic virotherapy with recombinant vaccinia viruses might constitute a novel treatment option for PSM. We aimed to identify the most effective oncolytic vaccinia v
Externí odkaz:
https://doaj.org/article/fb829cf6fb97427db64c6509110dfa98
Autor:
Lara M. Schüssele, Julia Koch-Heier, Julian Volk, Markus W. Löffler, Katharina Hoffmann, Regina M. Bruyns, Oliver Planz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The Raf/MEK/ERK signaling pathway plays a key role in regulating cellular proliferation, differentiation, apoptosis, cytokine production, and immune responses. However, it is also involved in diseases such as cancer, and numerous viruses rely on an a
Externí odkaz:
https://doaj.org/article/570a196fc06649cd97cda4740a096598
Autor:
Peter Bauer, Hans-Georg Rammensee, Nadine Mockel-Tenbrinck, Andrzej Dzionek, Andreas Schlosser, Michael Ghosh, Markus W Löffler, Sandra Schwarz, Johanna Schmitz, Evgenia Olshvang, Marvin Markel, Susann Krake, Basak Arslan, Kapil Dev Kampe, Anne Wendt, Christina S Mullins, Michael Linnebacher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Patients with cancers that exhibit extraordinarily high somatic mutation numbers are ideal candidates for immunotherapy and enable identifying tumor-specific peptides through stimulation of tumor-reactive T cells (Tc).Methods Colorectal ca
Externí odkaz:
https://doaj.org/article/e440eaa0b4e347af8ad56649eb46ec22
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundOrf virus (ORFV)-based vectors are attractive for vaccine development as they enable the induction of potent immune responses against specific transgenes. Nevertheless, the precise mechanisms of immune activation remain unknown. This study
Externí odkaz:
https://doaj.org/article/8c0857fdd2ef4c57b279ed84695e51ca
Autor:
Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NE
Externí odkaz:
https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c4
Autor:
Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Anoop Chandran, Henning Zelba, Elisa Rusch, Cécile Gouttefangeas, Daniel J. Kowalewski, Moreno Di Marco, Sebastian P. Haen, Juliane S. Walz, Yamel Cardona Gloria, Johanna Bödder, Jill-Marie Schertel, Antje Tunger, Luise Müller, Maximilian Kießler, Rebekka Wehner, Marc Schmitz, Meike Jakobi, Nicole Schneiderhan-Marra, Reinhild Klein, Karoline Laske, Kerstin Artzner, Linus Backert, Heiko Schuster, Johannes Schwenck, Alexander N. R. Weber, Bernd J. Pichler, Manfred Kneilling, Christian la Fougère, Stephan Forchhammer, Gisela Metzler, Jürgen Bauer, Benjamin Weide, Wilfried Schippert, Stefan Stevanović, Markus W. Löffler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background We previously showed that the bacterial lipopeptide Pam3Cys-Ser-Ser, meanwhile established as a toll-like receptor (TLR) 1/2 ligand, acts as a strong adjuvant for the induction of virus specific CD8+ T cells in mice, when covalent
Externí odkaz:
https://doaj.org/article/cc3a16412b7c49e5953df66f2cd4dccd