Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Markus Trunzer"'
Publikováno v:
Molecular Pharmaceutics. 20:383-394
In pharmaceutical research, compounds are optimized for metabolic stability to avoid a too fast elimination of the drug. Intrinsic clearance (CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241c4d76b720399e727161ab80fe61dd
https://doi.org/10.1021/acs.molpharmaceut.2c00680
https://doi.org/10.1021/acs.molpharmaceut.2c00680
Autor:
Joachim Blanz, Philippe Ramstein, Thierry Délémonté, Reiner Aichholz, Werner Gertsch, Markus Trunzer, Jerôme Dayer, David Pearson, Gareth Williams
Publikováno v:
Journal of Mass Spectrometry. 52:210-217
Drug metabolism studies are performed in drug discovery to identify metabolic soft spots, detect potentially toxic or reactive metabolites and provide an early insight into potential species differences. The relative peak area approach is often used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10057a80e3525bd31fdc3bdd8631b7ac
https://doi.org/10.1002/jms.3918
https://doi.org/10.1002/jms.3918
Autor:
Joachim, Blanz, Gareth, Williams, Jerôme, Dayer, Thierry, Délémonté, Werner, Gertsch, Philippe, Ramstein, Reiner, Aichholz, Markus, Trunzer, David, Pearson
Publikováno v:
Journal of mass spectrometry : JMS. 52(4)
Drug metabolism studies are performed in drug discovery to identify metabolic soft spots, detect potentially toxic or reactive metabolites and provide an early insight into potential species differences. The relative peak area approach is often used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fd1584bb27f564a72a6d59bf79cac55
https://pubmed.ncbi.nlm.nih.gov/28152561
https://pubmed.ncbi.nlm.nih.gov/28152561
Publikováno v:
Drug Metabolism and Disposition. 39:1039-1046
Although reversible CYP3A inhibition testing is well established for predicting the drug-drug interaction potential of clinical candidates, time-dependent inhibition (TDI) has become the focus of drug designers only recently. Failure of several late-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847ef65b62781710d2a068b47e019970
https://doi.org/10.1124/dmd.110.037911
https://doi.org/10.1124/dmd.110.037911
Publikováno v:
Rapid Communications in Mass Spectrometry. 21:937-944
The study of the metabolic fate of drugs is essential for the safety assessment of new compounds in the drug development process. However, the characterization and structural elucidation of metabolites from in vivo experiments is still a very challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22fbfd17c88d3ed0a2a33fd953709e5
https://doi.org/10.1002/rcm.2918
https://doi.org/10.1002/rcm.2918
Autor:
Christian N. Parker, Dominic Hoepfner, Neil S. Ryder, N. Rao Movva, Daryl L. Richie, Jianshi Tao, Martin Pfeifer, Stephen B. Helliwell, Alfred Zimmerlin, Mathias Frederiksen, Stefan Reinker, Markus Trunzer, Shantanu Karkare, Jeffrey A. Porter, Sophie De Bonnechose, Andreas Hofmann
Systemic life-threatening fungal infections represent a significant unmet medical need. Cell-based, phenotypic screening can be an effective means of discovering potential novel antifungal compounds, but it does not address target identification, nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7566ef85c7829b1304750a33ab9ac73d
https://europepmc.org/articles/PMC3421618/
https://europepmc.org/articles/PMC3421618/
Publikováno v:
Journal of medicinal chemistry. 52(2)
Metabolic stability is a key property to enable drugs to reach therapeutic concentrations. Microsomal clearance assays are used to dial out labile compounds in early discovery phases. However, because they do not provide any information on soft spots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f063e5326526450e6bb65347c136540f
https://pubmed.ncbi.nlm.nih.gov/19108654
https://pubmed.ncbi.nlm.nih.gov/19108654
Publikováno v:
Journal of chromatography. A. 1157(1-2)
The determination of radioactivity from metabolite patterns in ADME studies in a low radioactivity/residue situation is a very challenging process requiring special technologies. The recently introduced TopCount technology uses LumaPlates for the col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102240f57d5a13d8094e69fdeb60cbe3
https://pubmed.ncbi.nlm.nih.gov/17466316
https://pubmed.ncbi.nlm.nih.gov/17466316
Autor:
Melanie Struwe, Ulla Plappert-Helbig, Douglas C. Bauer, Michael Kiffe, Markus Trunzer, Willi Suter
Publikováno v:
Toxicology. 226:70-71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f14ed83018a065793d1eb5680ba4ea
https://doi.org/10.1016/j.tox.2006.05.094
https://doi.org/10.1016/j.tox.2006.05.094
Publikováno v:
Journal of Medicinal Chemistry; Jan2009, Vol. 52 Issue 2, p329-335, 7p