Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Markus Thommes"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 510 (2024)
Solid dispersions are a promising approach to enhance the dissolution of poorly water-soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high thermodynamic stability. To understand the mechanisms leading to the faster di
Externí odkaz:
https://doaj.org/article/48b97703942b4d9d920024e3ade85f81
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 301 (2024)
Melt viscosity is an essential property in pharmaceutical processes such as mixing, extrusion, fused deposition modeling, and melt coating. Measuring and modeling of the melt viscosity for drug/polymer mixtures is essential for optimization of the ma
Externí odkaz:
https://doaj.org/article/42a492c9da984b9fa034ca3318c9ce3d
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2650 (2023)
An innovative strategy to address recent challenges in the oral administration of poorly soluble drugs is the formulation of amorphous solid dispersions (ASDs), where the drug is dissolved in a highly soluble carrier polymer. Therefore, special knowl
Externí odkaz:
https://doaj.org/article/87342e9c987546b1920c9cf2e17f51ee
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2039 (2023)
Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, cur
Externí odkaz:
https://doaj.org/article/78f61c34d9084931801b6cd6dfb5f91e
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1417 (2023)
Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients. In this context, the residence time and processing
Externí odkaz:
https://doaj.org/article/65898fe04ee14d698859b0c087979866
Autor:
Kevin Hoppe, Lukas Wischemann, Gerhard Schaldach, Reiner Zielke, Wolfgang Tillmann, Markus Thommes, Damian Pieloth
Publikováno v:
Atmosphere, Vol 14, Iss 4, p 640 (2023)
Depth filtration is a widespread technique for the separation of airborne particles. The evolution of the pressure difference within this process is determined to a significant extent by the filter structure. Simulations are an important tool for opt
Externí odkaz:
https://doaj.org/article/79c949759e37401aadff538af59ad2df
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1757 (2022)
Even though hot melt extrusion (HME) is a commonly applied process in the pharmaceutical area, determination of the optimal process parameters is demanding. The goal of this study was to find a rational approach for predetermining suitable extrusion
Externí odkaz:
https://doaj.org/article/127f11c265c345af9347f61d181fb262
Autor:
Raj Schneider, Jana Kerkhoff, Andreas Danzer, Amelie Mattusch, Andrijan Ohmann, Markus Thommes, Gabriele Sadowski
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100063- (2020)
Supersaturation profiles of amorphous indomethacin in aqueous solution containing 0.4 wt% and 4 wt% of isopropanol were predicted by combining separately-determined kinetics for dissolution, solution crystallization, and solid-state transformation. T
Externí odkaz:
https://doaj.org/article/0f8b03284ad04b0893bfb00f559a8721
Autor:
Friederike Wolbert, Ineke-Katharina Fahrig, Tobias Gottschalk, Christian Luebbert, Markus Thommes, Gabriele Sadowski
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 269 (2022)
In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the crystallization of APIs often limits long-term stability and th
Externí odkaz:
https://doaj.org/article/7ca870a42aed4eae857d4547e36cbef0
Autor:
Tim Feuerbach, Markus Thommes
Publikováno v:
Molecules, Vol 26, Iss 3, p 590 (2021)
The filament is the most widespread feedstock material form used for fused deposition modeling printers. Filaments must be manufactured with tight dimensional tolerances, both to be processable in the hot-end and to obtain printed objects of high qua
Externí odkaz:
https://doaj.org/article/20e40ebaa3ec4325914f7496127901bf