Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Markus T. Bohnsack"'
Autor:
Junqiao Jia, Tarek Hilal, Katherine E. Bohnsack, Aleksandar Chernev, Ning Tsao, Juliane Bethmann, Aruna Arumugam, Lane Parmely, Nicole Holton, Bernhard Loll, Nima Mosammaparast, Markus T. Bohnsack, Henning Urlaub, Markus C. Wahl
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
ASCC3 is a multi-functional helicase that contains two consecutive Ski2-like helicase units. Here, the authors show that ASCC3 can unwind DNA by threading one strand of a substrate duplex through both helicase units, supported by the TRIP4 protein.
Externí odkaz:
https://doaj.org/article/0ee2586a4c9f44dfb7f3b09d1b9bc981
Autor:
Shiladitya Chattopadhyay, Jose Garcia-Martinez, Gal Haimovich, Jonathan Fischer, Aya Khwaja, Oren Barkai, Silvia Gabriela Chuartzman, Maya Schuldiner, Ron Elran, Miriam I. Rosenberg, Shira Urim, Shubham Deshmukh, Katherine E. Bohnsack, Markus T. Bohnsack, Jose E. Perez-Ortin, Mordechai Choder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
Externí odkaz:
https://doaj.org/article/76e659328ff74fa9b932927ad681792b
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.
Externí odkaz:
https://doaj.org/article/b66a7c73278d4acdb1a5947679641b80
Autor:
Gerald Ryan R. Aquino, Philipp Hackert, Nicolai Krogh, Kuan-Ting Pan, Mariam Jaafar, Anthony K. Henras, Henrik Nielsen, Henning Urlaub, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Early steps of large 60S ribosomal subunit biogenesis are not well understood. Here, the authors combine biochemical experiments with protein-RNA crosslinking and mass spectrometry to show that the RNA helicase Dbp7 is key player during early 60S rib
Externí odkaz:
https://doaj.org/article/c9348e45ad3e4a0888725af478868ba9
Autor:
Mariam Jaafar, Julia Contreras, Carine Dominique, Sara Martín-Villanueva, Régine Capeyrou, Patrice Vitali, Olga Rodríguez-Galán, Carmen Velasco, Odile Humbert, Nicholas J. Watkins, Eduardo Villalobo, Katherine E. Bohnsack, Markus T. Bohnsack, Yves Henry, Raghida Abou Merhi, Jesús de la Cruz, Anthony K. Henras
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The molecular events underlying the assembly and maturation of the early pre-60S particles during eukaryotic ribosome synthesis are not well understood. Here, the authors combine yeast genetics and biochemical experiments to characterise the function
Externí odkaz:
https://doaj.org/article/7fd76226be9d46f2a5651aafacd83be9
Autor:
Junqiao Jia, Eva Absmeier, Nicole Holton, Agnieszka J. Pietrzyk-Brzezinska, Philipp Hackert, Katherine E. Bohnsack, Markus T. Bohnsack, Markus C. Wahl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stabl
Externí odkaz:
https://doaj.org/article/d118f2503a854806ab453466797e9c86
Autor:
Mehmet Birikmen, Katherine E. Bohnsack, Vinh Tran, Sharvari Somayaji, Markus T. Bohnsack, Ingo Ebersberger
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Ribosome assembly is an essential and carefully choreographed cellular process. In eukaryotes, several 100 proteins, distributed across the nucleolus, nucleus, and cytoplasm, co-ordinate the step-wise assembly of four ribosomal RNAs (rRNAs) and appro
Externí odkaz:
https://doaj.org/article/5f835ce2e5764c09b6dd5a94707cf3fc
Autor:
Lukas Brüning, Philipp Hackert, Roman Martin, Jimena Davila Gallesio, Gerald Ryan R. Aquino, Henning Urlaub, Katherine E. Sloan, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Pre-ribosomes undergo numerous structural rearrangements during their assembly. Here the authors identify the binding sites of three essential RNA helicases on pre-ribosomal particles, enabling them to provide insights into the structural and composi
Externí odkaz:
https://doaj.org/article/60281cffa46941bcbffe87e438136b67
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 237-247 (2013)
Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosom
Externí odkaz:
https://doaj.org/article/c0ceca099e5442e7b3fcc741f4dc837d
Publikováno v:
Trends in Biochemical Sciences. 47:596-608
Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936f5311b345de7559bb4054ae598eb1
https://doi.org/10.1016/j.tibs.2022.03.004
https://doi.org/10.1016/j.tibs.2022.03.004