Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Markus Stephan-Gueldner"'
This chapter describes options and limitations for the selection of animal species that should be considered before resorting to the nonhuman primate as a model in nonclinical research and development, with a focus on regulatory toxicology. Situation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76012badf0007738e945b8583ad10e7a
https://doi.org/10.1016/b978-0-12-417144-2.00017-2
https://doi.org/10.1016/b978-0-12-417144-2.00017-2
Autor:
Paul Barrow, Kathryn Bayne, Joerg Bluemel, Frank Brennan, Iris D. Bolton, Christopher J. Bowman, Wayne R. Buck, Leigh Ann Burns-Naas, David B. Burr, Jennifer A. Cann, Annick J. Cauvin, Joy A. Cavagnaro, Ulrich Certa, Kathryn Chapman, Gary J. Chellman, Timothy P. Coogan, Jessica Couch, Lolke de Haan, Thierry Decelle, Annie Delaunois, Raffaella Faggioni, Betsy Ferguson, John Finch, Virginia Fisher, Werner Frings, Thomas Gelzleichter, Andreas Gschwind, Robert Hall, Wendy G. Halpern, Tobias Heckel, Kristin L. Henson, Susan Henwood, Jonathan R. Heyen, William Oliver Iverson, Mary Jeanne Kallman, Joachim Kaspareit, Tina Koban, Sven Korte, Pierre Lainée, Michael W. Leach, Lynne LeSauteur, Anne D. Lewis, Beatriz Silva Lima, Yanfei L. Ma, Keith G. Mansfield, C. Marc Luetjens, Pauline L. Martin, Kerstin Mätz-Rensing, Lars Fris Mikkelsen, Barbara Mounho-Zamora, Wolfgang Müller, Dennis J. Murphy, Marc Niehoff, Birgit Niggemann, Helen Palmer, Daniel J. Patrick, Christopher Peters, Marie-Soleil Piché, Mark Prescott, Kamm Prongay, Marlon C. Rebelatto, Alexandre Reymond, Laura Richman, Christian Roos, Lorin K. Roskos, Chandrassegar Saravanan, Vito G. Sasseville, Emanuel Schenck, Georg Schmitt, Jacintha M. Shenton, Anjali Singh, Matthew Skinner, David Glenn Smith, Markus Stephan-Gueldner, Marque Todd, Chih-Ming L. Tseng, John L. Vahle, Jean-Pierre Valentin, Hugo M. Vargas, Eric Wakshull, Lutz Walter, Gerhard F. Weinbauer, Joachim Wistuba, Harry Yang, Dietmar Zinner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc7e40da8c9c9a862d5e68f270d49f3
https://doi.org/10.1016/b978-0-12-417144-2.09993-5
https://doi.org/10.1016/b978-0-12-417144-2.09993-5
Autor:
Yvon Rabemampianina, Lieve Lammens, Markus Stephan-Gueldner, Friedrich von Landenberg, Claudia Stark, Olympe Depelchin, Rudolf Pfister, David M. Smith, Robert Combes, Ruediger Hack, Joerg Luft, Barry Phillips, Soren Dyring Jacobsen, Susan Sparrow
Publikováno v:
Regulatory Toxicology and Pharmacology. 41:95-101
A working party, comprising two animal welfare organisations and some 12 pharmaceutical companies in Europe, was established to minimise the use of the dog in safety testing. As first step, the participants defined the major objectives of preliminary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddeeee3a8ebf7ffebe09170b4c03e50
https://doi.org/10.1016/j.yrtph.2004.10.006
https://doi.org/10.1016/j.yrtph.2004.10.006
Autor:
Rudolf Pfister, Richard Fosse, Klaus Krauser, Barry Phillips, James Sanders, Sue Sparrow, Caren Broadhead, Soren Dyring Jacobsen, Markus Stephan-Gueldner, Ruediger Hack, David M. Smith, Yvon Rabemampianina, Gerard Descotes
Publikováno v:
ILAR Journal. 43:S39-S42
This review of the dog, the primary nonrodent species used in toxicology, and its use in the safety evaluation of pharmaceuticals, provides data on the number used in particular projects in an effort to establish a baseline from which some minimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367d0d8866f144f49ff8155297011768
https://doi.org/10.1093/ilar.43.suppl_1.s39
https://doi.org/10.1093/ilar.43.suppl_1.s39
Autor:
Klaus Krauser, Gerard Descotes, David M. Smith, Yvon Rabemampianina, Friedrich von Landenberg, Soren Dyring Jacobsen, Ruediger Hack, Robert Combes, Barry Phillips, Sue Sparrow, Rudolf Pfister, Joerg Kemkowski, Markus Stephan-Gueldner
Publikováno v:
Alternatives to laboratory animals : ATLA. 32
The primary non-rodent species used in toxicology is the dog. It is generally agreed that, for ethical reasons, dog use should be reduced to the minimum consistent with maintaining the scientific quality of toxicology studies and ensuring human safet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f96221d06b24e56d68d6fe920e9d617
https://pubmed.ncbi.nlm.nih.gov/23581116
https://pubmed.ncbi.nlm.nih.gov/23581116
Autor:
Thomas R, Sutter, Xiao-Rui, He, Peter, Dimitrov, Lijing, Xu, Giri, Narasimhan, E Olusegun, George, Carrie Hayes, Sutter, Clinton, Grubbs, Richard, Savory, Markus, Stephan-Gueldner, Dirk, Kreder, Michael J, Taylor, Ronald, Lubet, Tricia A, Patterson, Thomas W, Kensler
Publikováno v:
Molecular cancer therapeutics. 1(14)
Microarray technology has greatly aided the identification of genes that are expressed differentially. Statistical analysis of such data by multiple comparisons procedures has been slow to develop, in part, because methods to cluster the results of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce9547e914474f22374d2b066fe5b420
https://pubmed.ncbi.nlm.nih.gov/12516961
https://pubmed.ncbi.nlm.nih.gov/12516961
Autor:
Markus Stephan-Gueldner, Akira Inomata
Publikováno v:
Toxicology letters.
Endothelins are potent vasoconstrictors and pressor peptides and are important mediators of cardiac, renal and endocrine functions. Increased ET-1 levels in disease states such as congestive heart failure, pulmonary hypertension, acute myocardial inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eae88577f4385b41daf1d5f9fe6dd08
https://pubmed.ncbi.nlm.nih.gov/10720776
https://pubmed.ncbi.nlm.nih.gov/10720776
Autor:
Lieve Lammens, Peter Stei, Markus Stephan-Gueldner, Rudolf Pfister, Claudia Stark, David M. Smith, Yvon Rabemampianina, Annie Delaunois, Joerg Luft, Friedrich von Landenberg, Ruediger Hack, Barry Phillips, Sue Sparrow, Robert Combes, Anna-Mette Paarup
Publikováno v:
Toxicology. 231:97-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf2e8d8ca51bdd2263748465ae564f8
https://doi.org/10.1016/j.tox.2006.11.020
https://doi.org/10.1016/j.tox.2006.11.020
Autor:
E. F. J. de Vries, Klaas Poelstra, Vineet Mahajan, R. A. J. O. Dierckx, Markus Stephan-Gueldner, Robert A. Comley
Publikováno v:
Toxicology Letters. 221:S50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f09f1ff02ee1e19f5442f8544175f8f
https://doi.org/10.1016/j.toxlet.2013.06.184
https://doi.org/10.1016/j.toxlet.2013.06.184
Autor:
David M. Smith, Klaus Krauser, Lieve Lammens, Markus Stephan-Gueldner, S.Dyring Jacobsen, Gerard Descotes, F. von Landenberg, Yvon Rabemampianina, Robert Combes, J. Kemkowski, Rudolf Pfister, Susan Sparrow, Barry Phillips, Ruediger Hack
Publikováno v:
Toxicology Letters. 144:s48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce53f398ecd0c51d9708d7b847e98938
https://doi.org/10.1016/s0378-4274(03)90166-4
https://doi.org/10.1016/s0378-4274(03)90166-4