Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Markus Sperandio"'
Autor:
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107883- (2023)
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not wel
Externí odkaz:
https://doaj.org/article/d157d4c503524879adbc519f7beab15b
Autor:
Ina Rohwedder, Lou Martha Wackerbarth, Kristina Heinig, Annamaria Ballweg, Johannes Altstätter, Myriam Ripphahn, Claudia Nussbaum, Melanie Salvermoser, Susanne Bierschenk, Tobias Straub, Matthias Gunzer, Marc Schmidt-Supprian, Thomas Kolben, Christian Schulz, Averil Ma, Barbara Walzog, Matthias Heinig, Markus Sperandio
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptomic analysis
Externí odkaz:
https://doaj.org/article/e87a9995376c4685aecbb7a8084026ca
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The release of neutrophils from the bone marrow into the blood circulation is essential for neutrophil homeostasis and the protection of the organism from invading microorganisms. Granulocyte colony-stimulating factor (G-CSF) plays a pivotal role in
Externí odkaz:
https://doaj.org/article/dbfe815224024da49e6b308619ae5c92
Autor:
Zhi Ma, Huixia Yang, Mirjana Kessler, Markus Sperandio, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundCarbohydrate Lewis antigens including sialyl Lewis A (sLeA), sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are the commonest cell surface glycoconjugates that play pivotal roles in multiple biological processes, including cell adh
Externí odkaz:
https://doaj.org/article/888f9de785684dc1bad6c09af4f8fdf3
Autor:
Tarik Bozoglu, Seungmin Lee, Tilman Ziegler, Victoria Jurisch, Sanne Maas, Andrea Baehr, Rabea Hinkel, Amelie Hoenig, Anjana Hariharan, Christina Inyeop Kim, Simon Decker, Haider Sami, Tobias Koppara, Ruppert Oellinger, Oliver J. Müller, Derk Frank, Remco Megens, Peter Nelson, Christian Weber, Angelika Schnieke, Markus Sperandio, Gianluca Santamaria, Roland Rad, Alessandra Moretti, Karl‐Ludwig Laugwitz, Oliver Soehnlein, Manfred Ogris, Christian Kupatt
Publikováno v:
Advanced Science, Vol 9, Iss 7, Pp n/a-n/a (2022)
Abstract Adeno‐associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV‐transduction. AAVs are retargeted here toward endothelial cell
Externí odkaz:
https://doaj.org/article/65930d80b39b468ba304c58ed6fc37b2
Autor:
Martin Bernhard Müller, Max Hübner, Lei Li, Stephanie Tomasi, Valena Ließke, David Effinger, Simon Hirschberger, Kristin Pogoda, Markus Sperandio, Simone Kreth
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Opening of the endothelial barrier and targeted infiltration of leukocytes into the affected tissue are hallmarks of the inflammatory response. The molecular mechanisms regulating these processes are still widely elusive. In this study, we elucidate
Externí odkaz:
https://doaj.org/article/91faa68c6d4f4bfaa6b92f0658812ab5
Autor:
Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weißenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate slow
Externí odkaz:
https://doaj.org/article/c3cea8679646465e990db2cdccfaa565
Autor:
Bernd Uhl, Laura AMittmann, Julian Dominik, Roman Hennel, Bojan Smiljanov, Florian Haring, Johanna BSchaubächer, Constanze Braun, Lena Padovan, Robert Pick, Martin Canis, Christian Schulz, Matthias Mack, Ewgenija Gutjahr, Peter Sinn, Jörg Heil, Katja Steiger, Sandip M Kanse, Wilko Weichert, Markus Sperandio, Kirsten Lauber, Fritz Krombach, Christoph A Reichel
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 6, Pp n/a-n/a (2021)
Abstract High intratumoral levels of urokinase‐type plasminogen activator (uPA)‐plasminogen activator inhibitor‐1 (PAI‐1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protei
Externí odkaz:
https://doaj.org/article/4c70973c2a744ff8b94cdcdb9b282bf8
Publikováno v:
eLife, Vol 10 (2021)
At the transition from intrauterine to postnatal life, drastic alterations are mirrored by changes in cellular immunity. These changes are in part immune cell intrinsic, originate in the replacement of fetal cells, or result from global regulatory me
Externí odkaz:
https://doaj.org/article/659eaf60aa534c999cbccbdb061db1fc
Publikováno v:
Cells, Vol 11, Iss 9, p 1532 (2022)
The use of cell-based reporter systems has provided valuable insights into the molecular mechanisms of integrin activation. However, current models have significant drawbacks because their artificially expressed integrins cannot be regulated by eithe
Externí odkaz:
https://doaj.org/article/7198afa3aee64ef991be744c43d4d356