Zobrazeno 1 - 10 of 127 pro vyhledávání: '"Markus Schultheiss"'
1
Akademický článek
Desmoplastic Small Round Cell Tumors: Clinical Presentation, Molecular Characterization, and Therapeutic Approach of Seven Patients
Autor: Verena I. Gaidzik, Regine Mayer-Steinacker, Mathias Wittau, Markus Schultheiß, Alexandra v. Baer, Kathrin Oehl-Huber, Sonja Dahlum, Anja Fischer, Uwe Gerstenmaier, Thomas Seufferlein, Andreas Buck, Ambros Beer, Wolfgang Thaiss, Peter Möller, Hartmut Döhner, Reiner Siebert, Ralf Marienfeld, Thomas F. E. Barth
Publikováno v: Sarcoma, Vol 2024 (2024)
Desmoplastic small round blue cell tumor (DSRCT) is a highly aggressive fatal sarcoma without evidence-based therapeutic guidelines. We present here seven patients with DSRCT including immunohistochemistry combined with fluorescence in situ hybridiza
Externí odkaz: https://doaj.org/article/e31af91371f14d66b32445252728ef68
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2
Akademický článek
Impact of CDK Inhibitors on TBXT Expression in Chordoma Cell Lines Including the First Stable Cell Line of a High-Grade Chordoma
Autor: Sarah Bette, Luisa Haase, Juliane Nell, Thomas Grieser, Alexandra von Baer, Markus Schultheiss, Ralf Marienfeld, Peter Möller, Thomas F. E. Barth, Kevin Mellert
Publikováno v: Diagnostics, Vol 14, Iss 10, p 1028 (2024)
Chordomas are very rare malignant neoplasms of the bone occurring almost exclusively along the spine. As the tumours are thought to arise from notochordal remnants, the vast majority of chordomas express the TBXT gene, resulting in detectable nuclear
Externí odkaz: https://doaj.org/article/6a8a064469eb46fbbb09d92eac438ea1
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3
Akademický článek
Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation
Autor: Marc Hasenfratz, Kevin Mellert, Ralf Marienfeld, Alexandra von Baer, Markus Schultheiss, P. D. Roitman, L. A. Aponte-Tinao, Burkhard Lehner, Peter Möller, Gunhild Mechtersheimer, Thomas F. E. Barth
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Giant cell tumor of bone (GCTB) is a locally aggressive lesion of intermediate malignancy. Malignant transformation of GCTB is a rare event. In 2013, the humanized monoclonal antibody against receptor activator of nuclear factor-κb-Ligand (
Externí odkaz: https://doaj.org/article/7e362e1fc5aa4bdcbb09fa7a3c4adf92
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4
Akademický článek
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas
Autor: Daniela Jäger, Thomas F. E. Barth, Silke Brüderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, André Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss, Christian R. Wirtz, Peter Möller, Kevin Mellert
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Chordomas are rare tumours of the bone arising along the spine from clivus to sacrum. We compared three chordoma cell lines of the clivus region including the newly established clivus chordoma cell line, U-CH14, with nine chordoma cell lines
Externí odkaz: https://doaj.org/article/0d1eed0325ea49689979e4d5afd31ace
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6
Akademický článek
Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib
Autor: Michael J. Böhm, Ralf Marienfeld, Daniela Jäger, Kevin Mellert, Adrian von Witzleben, Silke Brüderlein, Mathias Wittau, Alexandra von Baer, Markus Schultheiss, Regine Mayer-Steinacker, Frank G. Rücker, Peter Möller, Lars Bullinger, Thomas F. E. Barth
Publikováno v: Sarcoma, Vol 2019 (2019)
Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we profiled genomic aberrations in a small cohort of eight primary tumours, two relapses, and eight m
Externí odkaz: https://doaj.org/article/8b49dfb082ed4a899ba3d82ba9ca5faa
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