Výsledky vyhledávání - "Markus Schlomm"

The cellular prion protein and its derived fragments in human prion diseases and their role as potential biomarkers

Autor: Saima Zafar, Anna Villar-Piqué, Hermann C. Altmeppen, Matthias Schmitz, Franc Llorens, Katrin Thüne, Inga Zerr, Markus Glatzel, Markus Schlomm

Publikováno v: Expert review of molecular diagnostics 19(11), 1007-1018 (2019). doi:10.1080/14737159.2019.1667231

Introduction: Human prion diseases are a heterogeneous group of incurable and debilitating conditions characterized by a progressive degeneration of the central nervous system. The conformational changes of the cellular prion protein and its formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f6f5688ca2d018f4afb353222ae78b
https://pubmed.ncbi.nlm.nih.gov/31512940

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Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease

Autor: Daniela Varges, Badrul Hasan, Julie Carimalo, Michael Beekes, Eva Mitrova, Markus Schlomm, Inga Zerr, Matthias Schmitz, Carsten Korth, Andreas Breil, Joanna Gawinecka

Publikováno v: European Journal of Neuroscience. 31:2024-2031

The cellular prion protein (PrP(c)) is a multifunctional, highly conserved and ubiquitously expressed protein. It undergoes a number of modifications during its post-translational processing, resulting in different PrP(c) glycoforms and truncated PrP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcd8c87fa64fe50f7e0d1dc0f73f2dec
https://doi.org/10.1111/j.1460-9568.2010.07224.x

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Association of prion protein genotype and scrapie prion protein type with cellular prion protein charge isoform profiles in cerebrospinal fluid of humans with sporadic or familial prion diseases

Autor: Saima Zafar, Katharina Lüllmann, Panteleimon Oikonomou, Elisabeth Ebert, Michael Beekes, Markus Schlomm, Matthias Schmitz, Inga Zerr, Marie Wohlhage, Eva Mitrova

Publikováno v: Neurobiology of Aging
Neurobiology of aging 35(5), 1177-1188 (2014). doi:10.1016/j.neurobiolaging.2013.11.010

The present study investigates whether posttranslational modifications of cellular prion protein (PrP(C)) in the cerebrospinal fluid (CSF) of humans with prion diseases are associated with methionine (M) and/or valine (V) polymorphism at codon 129 of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8e12b295f55297b0a4e0711a12dbbd
https://pubmed.ncbi.nlm.nih.gov/24360565

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