Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Markus Ringnér"'
Autor:
Roberta Filograna, Jule Gerlach, Hae-Na Choi, Giovanni Rigoni, Michela Barbaro, Mikael Oscarson, Seungmin Lee, Katarina Tiklova, Markus Ringnér, Camilla Koolmeister, Rolf Wibom, Sara Riggare, Inger Nennesmo, Thomas Perlmann, Anna Wredenberg, Anna Wedell, Elisa Motori, Per Svenningsson, Nils-Göran Larsson
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pat
Externí odkaz:
https://doaj.org/article/5261e43905b84e29a138f193cac7150a
Autor:
Shumaila Sayyab, Anders Lundmark, Malin Larsson, Markus Ringnér, Sara Nystedt, Yanara Marincevic-Zuniga, Katja Pokrovskaja Tamm, Jonas Abrahamsson, Linda Fogelstrand, Mats Heyman, Ulrika Norén-Nyström, Gudmar Lönnerholm, Arja Harila-Saari, Eva C. Berglund, Jessica Nordlund, Ann-Christine Syvänen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission fro
Externí odkaz:
https://doaj.org/article/df7f00d635d847359cec38029b48a552
Autor:
Nathalie Feiner, Reinder Radersma, Louella Vasquez, Markus Ringnér, Björn Nystedt, Amanda Raine, Elmar W. Tobi, Bastiaan T. Heijmans, Tobias Uller
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104303- (2022)
Summary: Transgenerational inheritance of environmentally induced epigenetic marks can have significant impacts on eco-evolutionary dynamics, but the phenomenon remains controversial in ecological model systems. We used whole-genome bisulfite sequenc
Externí odkaz:
https://doaj.org/article/188bb20cd9a9433a9972f68e1d54efe1
Autor:
Shamik Mitra, Martin Lauss, Rita Cabrita, Jiyeon Choi, Tongwu Zhang, Karolin Isaksson, Håkan Olsson, Christian Ingvar, Ana Carneiro, Johan Staaf, Markus Ringnér, Kari Nielsen, Kevin M. Brown, Göran Jönsson
Publikováno v:
Molecular Oncology, Vol 14, Iss 5, Pp 933-950 (2020)
The presence of immune cells in the tumor microenvironment has been associated with response to immunotherapies across several cancer types, including melanoma. Despite its therapeutic relevance, characterization of the melanoma immune microenvironme
Externí odkaz:
https://doaj.org/article/ea1b27aaf4e44965bc4683fbca62bede
Autor:
Roberta Filograna, Seungmin Lee, Katarína Tiklová, Mara Mennuni, Viktor Jonsson, Markus Ringnér, Linda Gillberg, Elena Sopova, Oleg Shupliakov, Camilla Koolmeister, Lars Olson, Thomas Perlmann, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009822 (2021)
Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial damage over time and mitochondrial defects have been frequently reported in Parkinson's disease (PD) patients. However, the causal contribution of adult-onset mitoc
Externí odkaz:
https://doaj.org/article/61f2fcf7bb484163bdda169112e41b0e
Autor:
Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that the
Externí odkaz:
https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f
Autor:
Michael Bartoschek, Nikolay Oskolkov, Matteo Bocci, John Lövrot, Christer Larsson, Mikael Sommarin, Chris D. Madsen, David Lindgren, Gyula Pekar, Göran Karlsson, Markus Ringnér, Jonas Bergh, Åsa Björklund, Kristian Pietras
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putative
Externí odkaz:
https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf
Autor:
Erik Södersten, Konstantinos Toskas, Vilma Rraklli, Katarina Tiklova, Åsa K. Björklund, Markus Ringnér, Thomas Perlmann, Johan Holmberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The limited size of some neuronal types and their entangled environment renders it difficult to study their transcription regulation. Here the authors present a comparative analysis of histone modifications and transcription in dopaminergic and serot
Externí odkaz:
https://doaj.org/article/6df7c45a61984546bf5cda6b2f25f8ed
Autor:
Martin Lauss, Marco Donia, Katja Harbst, Rikke Andersen, Shamik Mitra, Frida Rosengren, Maryem Salim, Johan Vallon-Christersson, Therese Törngren, Anders Kvist, Markus Ringnér, Inge Marie Svane, Göran Jönsson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Adoptive T cell therapy (ACT) has yielded high response rates in melanoma, however 50–60% of patients experience no clinical benefit. Here, the authors identify predictive biomarkers, high non-synonymous mutation and high expressed neoantigen load,
Externí odkaz:
https://doaj.org/article/63635278846d435eabbeb4ee5d2c1d15
Autor:
Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B. Brinkman, Marc J. van de Vijver, Andrea L. Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R. Davies, Reno Debets, Marion E. Meijer-Van Gelder, Carolien H. M. van Deurzen, Gaëtan MacGrogan, Gert G. G. M. Van den Eynden, Colin Purdie, Alastair M. Thompson, Carlos Caldas, Paul N. Span, Peter T. Simpson, Sunil R. Lakhani, Steven Van Laere, Christine Desmedt, Markus Ringnér, Stefania Tommasi, Jorunn Eyford, Annegien Broeks, Anne Vincent-Salomon, P. Andrew Futreal, Stian Knappskog, Tari King, Gilles Thomas, Alain Viari, Anita Langerød, Anne-Lise Børresen-Dale, Ewan Birney, Hendrik G. Stunnenberg, Mike Stratton, John A. Foekens, John W. M. Martens
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures
Externí odkaz:
https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b