Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Markus P Radsak"'
Autor:
Katarzyna Bogucka, Malvika Pompaiah, Federico Marini, Harald Binder, Gregory Harms, Manuel Kaulich, Matthias Klein, Christian Michel, Markus P Radsak, Sebastian Rosigkeit, Peter Grimminger, Hansjörg Schild, Krishnaraj Rajalingam
Publikováno v:
eLife, Vol 9 (2020)
ERK3 is a ubiquitously expressed member of the atypical mitogen activated protein kinases (MAPKs) and the physiological significance of its short half-life remains unclear. By employing gastrointestinal 3D organoids, we detect that ERK3 protein level
Externí odkaz:
https://doaj.org/article/aa245781e7d048d6adf5fe6eec0917b5
Autor:
Anita G. Kansy, Ramy Ashry, Al‐Hassan M. Mustafa, Abdallah M. Alfayomy, Markus P. Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1958-1965 (2024)
Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia‐telangiectasia‐and‐RAD3‐rela
Externí odkaz:
https://doaj.org/article/3c603aa7f4ed49c783038eaa1696cb4c
Autor:
Pamela Stein, Karsten Gogoll, Stefan Tenzer, Hansjörg Schild, Stefan Stevanovic, Peter Langguth, Markus P Radsak
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102664 (2014)
BACKGROUND:Transcutaneous immunization (TCI) approaches utilize skin associated lymphatic tissues to elicit specific immune responses. In this context, the imidazoquinoline derivative imiquimod formulated in Aldara applied onto intact skin together w
Externí odkaz:
https://doaj.org/article/2ec1ed0436d14bf589bc00c0f12cdf93
Autor:
Sophie Luise Meiser, Jonas Pielenhofer, Ann-Kathrin Hartmann, Lara Stein, Jule Dettweiler, Stephan Grabbe, Markus P. Radsak, Peter Langguth
Publikováno v:
Frontiers in Drug Delivery, Vol 4 (2024)
Transcutaneous delivery systems bear several advantages over conventional needle-based injections. Considering the low bioavailability and poor water-solubility of imiquimod, a manufacturing process has been developed to incorporate imiquimod as susp
Externí odkaz:
https://doaj.org/article/84b0248e65984210829b7ef189071e4b
Autor:
Michael Weber, Corinna Lupp, Pamela Stein, Andreas Kreft, Tobias Bopp, Thomas C Wehler, Edgar Schmitt, Hansjörg Schild, Markus P Radsak
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58110 (2013)
Graft-versus-host disease (GvHD) is a key contributor to the morbidity and mortality after allogeneic hematopoetic stem cell transplantation (HSCT). Regulatory Foxp3(+) CD4(+) T cells (Treg) suppress conventional T cell activation and can control GvH
Externí odkaz:
https://doaj.org/article/3aa9ac90f4894c5e991c6fbf2f71b863
Autor:
Gerd Gladigau, Philipp Haselmayer, Inge Scharrer, Markus Munder, Nadine Prinz, Karl Lackner, Hansjörg Schild, Pamela Stein, Markus P Radsak
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42176 (2012)
The anti-phospholipid syndrome (APS) is characterized by recurrent thrombosis and occurrence of anti-phospholipid antibodies (aPL). aPL are necessary, but not sufficient for the clinical manifestations of APS. Growing evidence suggests a role of inna
Externí odkaz:
https://doaj.org/article/2077a1f4c8974df586961238e9f74ec3
Autor:
Pamela Stein, Michael Weber, Steve Prüfer, Beate Schmid, Edgar Schmitt, Hans-Christian Probst, Ari Waisman, Peter Langguth, Hansjörg Schild, Markus P Radsak
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27911 (2011)
The imidazoquinoline derivate imiquimod induces inflammatory responses and protection against transplanted tumors when applied to the skin in combination with a cognate peptide epitope (transcutaneous immunization, TCI). Here we investigated the role
Externí odkaz:
https://doaj.org/article/91aaad18f25240d7af7b5e3f87b5a038
Autor:
Julian Sohl, Ann-Kathrin Hartmann, Jennifer Hahlbrock, Joschka Bartneck, Michael Stassen, Matthias Klein, Matthias Bros, Stephan Grabbe, Federico Marini, Kevin Woods, Borhane Guezguez, Matthias Mack, Hansjörg Schild, Sabine Muth, Felix Melchior, Hans Christian Probst, Peter Langguth, Markus P. Radsak
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/f8b0c33b4f3c4a62a0d15ea12f4f381c
Autor:
Joschka Bartneck, Ann-Kathrin Hartmann, Lara Stein, Danielle Arnold-Schild, Matthias Klein, Michael Stassen, Federico Marini, Jonas Pielenhofer, Sophie Luise Meiser, Peter Langguth, Matthias Mack, Sabine Muth, Hans-Christian Probst, Hansjörg Schild, Markus Philipp Radsak
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tumor development and progression is shaped by the tumor microenvironment (TME), a heterogeneous assembly of infiltrating and resident host cells, their secreted mediators and intercellular matrix. In this context, tumors are infiltrated by various i
Externí odkaz:
https://doaj.org/article/b6b81cbb0f6c4c90b928a7619a5c1a38
Autor:
Ann-Kathrin Hartmann, Joschka Bartneck, Jonas Pielenhofer, Sophie Luise Meiser, Danielle Arnold-Schild, Matthias Klein, Michael Stassen, Hansjörg Schild, Sabine Muth, Hans Christian Probst, Peter Langguth, Stephan Grabbe, Markus P. Radsak
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTranscutaneous immunization (TCI) is a non-invasive vaccination method promoting strong cellular immune responses, crucial for the immunological rejection of cancer. Previously, we reported on the combined application of the TLR7 agonist
Externí odkaz:
https://doaj.org/article/45104fbc88c34ace9bbdff9da15c6608