Assessment of causality of natriuretic peptides and atrial fibrillation and heart failure – a Mendelian randomization study in the FINRISK cohort

Autor: C.J.K Fouodo, Markus O. Scheinhardt, Kari Kuulasmaa, B Geelhoed, C Boerschel, Veikko Salomaa, Renate B. Schnabel, Tanja Zeller, P. Jousilahti, Teemu J. Niiranen, Aki S. Havulinna, Stefan Blankenberg

Publikováno v: European Heart Journal. 41

Background Natriuretic peptides are extensively studied biomarkers for atrial fibrillation (AF) and heart failure (HF). Their role in the pathogenesis of both diseases is not entirely understood and in previous studies several single nucleotide polym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c91484d5b85d4256663a824d0043ba
https://doi.org/10.1093/ehjci/ehaa946.2931

Assessment of causality of natriuretic peptides and atrial fibrillation and heart failure: a Mendelian randomization study in the FINRISK cohort

Autor: Bastiaan Geelhoed, Veikko Salomaa, Teemu J. Niiranen, Tanja Zeller, Aki S. Havulinna, Stefan Blankenberg, Tarja Palosaari, Christin S. Börschel, Pekka Jousilahti, Césaire J K Fouodo, Renate B. Schnabel, Markus O. Scheinhardt, Kari Kuulasmaa

Publikováno v: Europace
EP Europace

Aims Natriuretic peptides are extensively studied biomarkers for atrial fibrillation (AF) and heart failure (HF). Their role in the pathogenesis of both diseases is not entirely understood and previous studies several single-nucleotide polymorphisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39be792b17bd1e6f1eb218d92812db54
https://pubmed.ncbi.nlm.nih.gov/32830215

Performance of prognostic modelling of high and low ovarian response to ovarian stimulation for IVF

Autor: Georg Griesinger, Markus O. Scheinhardt, Tamara Lerman, Inke R. König

Publikováno v: Human reproduction (Oxford, England). 33(8)

Study question What is the performance of previously established regression models in predicting low and high ovarian response to 150 μg corifollitropin alfa/GnRH-antagonist ovarian stimulation in an independent dataset? Summary answer The outcome o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864de9e8955a9e0d0e7e5b626d890a9b
https://pubmed.ncbi.nlm.nih.gov/30649363

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

Autor: Uwe K. Zettl, Michael Pütz, Rajesh Rawal, Frauke Zipp, Martin Stangel, Ulf Schminke, Marcus Ising, Martina Müller-Nurasyid, Heinz Wiendl, Jürgen Haas, Thomas Meitinger, Michael Hecker, Wolfgang Lieb, Magdalena Zoledziewska, Tania Carrillo-Roa, Ulf Ziemann, S. Nischwitz, Stefan Herms, Maristella Pitzalis, Stefan Kloiber, Frank Weber, Hayrettin Tumani, Bertram Müller-Myhsok, Sven G. Meuth, Georg Homuth, Ralf Gold, M. Knop, Antonella Mulas, Christina M. Lill, Henry Völzke, Antonios Bayas, Francesco Cucca, Eleonora Porcu, Andrew T. Chan, Janine Arloth, Lukas Bechmann, Darina Czamara, Dorothea Buck, Klaus Berger, Peter Lichtner, Jürgen Wellmann, Susanne Moebus, Andre Franke, Florian Then Bergh, Peter Weber, Thomas Bettecken, Ilenia Zara, Till F. M. Andlauer, Volker Limmroth, Achim Berthele, Ralf A. Linker, Tobias Ruck, Anke Salmen, Matthias Laudes, Gisela Antony, Christiane Graetz, Christian Gieger, Konstantin Strauch, Astrid Petersmann, Elisabeth B. Binder, Melanie Waldenberger, Christiane Gasperi, Carlo Sidore, Brigitte Wildemann, Friedemann Paul, Felix Luessi, Bernhard Hemmer, Klarissa Hanja Stürner, Karl-Heinz Jöckel, Milena Radivojkov-Blagojevic, Björn Tackenberg, Tim Kacprowski, Lars Bertram, Clemens Warnke, Markus O. Scheinhardt, Theresa Dankowski, Verena Loleit, Tania Kümpfel, Carmen Infante-Duarte, Susanne Lucae, Markus M. Nöthen, Jan-Patrick Stellmann, Mark Mühlau, Andreas Ziegler

Publikováno v: Sci. Adv. 2:e1501678 (2016)
Science advances
Andlauer, Till F M; Buck, Dorothea; Antony, Gisela; Bayas, Antonios; Bechmann, Lukas; Berthele, Achim; Chan, Andrew; Gasperi, Christiane; Gold, Ralf; Graetz, Christiane; Haas, Jürgen; Hecker, Michael; Infante-Duarte, Carmen; Knop, Matthias; Kümpfel, Tania; Limmroth, Volker; Linker, Ralf A; Loleit, Verena; Luessi, Felix; Meuth, Sven G; ... (2016). Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. Science Advances, 2(6), e1501678. American Association for the Advancement of Science 10.1126/sciadv.1501678
Science Advances

Genome-wide study in Germans identifies four novel multiple sclerosis risk genes and confirms already known gene loci.
We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09024c9b9a0412f283b1b4db24ebb8ef
http://hdl.handle.net/10044/1/39479

Location tests for biomarker studies: a comparison using simulations for the two-sample case

Autor: Andreas Ziegler, Markus O. Scheinhardt

Publikováno v: Methods of information in medicine. 52(4)

Summary Background: Gene, protein, or metabolite expression levels are often non-normally distributed, heavy tailed and contain outliers. Standard statistical approaches may fail as location tests in this situation. Objectives: In three Monte-Carlo s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614bc857d4193a73c7d2abd520267e4e
https://pubmed.ncbi.nlm.nih.gov/23877617