Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Markus Nahrwold"'
Autor:
Markus Nahrwold, Arvydas Stončius, Anna Penner, Beate Neumann, Hans-Georg Stammler, Norbert Sewald
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 43 (2009)
Novel procedures have been developed to condense benzaldehyde effectively with β-amino acid amides to cyclic benzyl aminals. Double carbamate protection of the heterocycle resulted in fully protected chiral β-alanine derivatives. These serve as uni
Externí odkaz:
https://doaj.org/article/0fbbce44f71e438681c4f89579d49c17
Autor:
Benedikt Sammet, Christine Weiß, Jens Conradi, Soledad Royo Gracia, Markus Nahrwold, Norbert Sewald, Ralf Palmisano, Felix Mertink, Thomas Preuße, Tobias Bogner
Publikováno v:
Journal of Medicinal Chemistry. 56:1853-1864
Tumor targeting anticancer drug conjugates that contain a tumor recognition motif (homing device) are of high current relevance. Cryptophycins, naturally occurring cytotoxic cyclo-depsipeptides, have been modified by total synthesis to provide analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5ce4e4972c259e90b93e7603d8df39
https://doi.org/10.1021/jm301346z
https://doi.org/10.1021/jm301346z
Publikováno v:
Synthesis. 2006:3747-3789
Nature provides a huge reservoir of highly diverse chemical compounds with interesting biological properties. Secondary metabolites continue to represent promising candidates for therapeutic applications and drugs are very often based on natural prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fccc8fd1d4ebf7e8a7b045b4fb3a00d
https://doi.org/10.1055/s-2006-950332
https://doi.org/10.1055/s-2006-950332
Publikováno v:
Organic Letters. 9:817-819
[reaction: see text] Two short synthetic approaches toward cryptophycin unit A comprise a catalytic asymmetric dihydroxylation as the sole source of chirality, while all further stereogenic centers are introduced under substrate control. The key step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ff5b3390aa5c9c8c3a1eb9fce4b62d
https://doi.org/10.1021/ol063032l
https://doi.org/10.1021/ol063032l
Publikováno v:
The Journal of organic chemistry. 75(20)
The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14c246788e173ee3d82b9b1cc344006
https://pubmed.ncbi.nlm.nih.gov/20857920
https://pubmed.ncbi.nlm.nih.gov/20857920
Publikováno v:
Organic letters. 12(5)
An endocyclic trans-amide linkage within the macrocyclic antitumor agent cryptophycin-52 was replaced by a 1,4-disubstituted 1H-1,2,3-triazole ring. Macrocyclisation of the triazole analogue was accomplished by macrolactamization as well as by Cu(I)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f219b6edccef5ecf674a708cab7b408e
https://pubmed.ncbi.nlm.nih.gov/20131817
https://pubmed.ncbi.nlm.nih.gov/20131817
Publikováno v:
ChemInform. 40
Many of today's most efficient anticancer chemotherapeutics interfere with microtubule dynamics. They prevent microtubules from forming correct mitotic spindles, therefore cause an arrest of the cell-division cycle and eventually trigger programmed c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7fe983f1aba8ab25bfcf46153155555
https://doi.org/10.1002/chin.200948244
https://doi.org/10.1002/chin.200948244
Cryptophycins are a family of highly cytotoxic, cyclic depsipeptides. They display antitumour activity that is largely maintained for multidrug-resistant tumour cells. Cryptophycins are composed of four building blocks (units A-D) that correspond to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e8c4b7da64edd6b053b9a78f562cf2
https://doi.org/10.1002/chem.200901750
https://doi.org/10.1002/chem.200901750
Five suitably protected enantiomerically pure beta(2)-amino acids, homologues of proteinogenic alpha-amino acids, were synthesized from the common chiral precursor, tert-butyl succinyloxazolidinone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d763a2d34bcfd04b96122ad79e351143
https://doi.org/10.1055/s-2005-865362
https://doi.org/10.1055/s-2005-865362
Publikováno v:
Synthesis; Jul2005, Vol. 2005 Issue 11, p1829-1837, 9p