Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Markus Muttenthaler"'
Publikováno v:
ACS Omega, Vol 9, Iss 35, Pp 37170-37182 (2024)
Externí odkaz:
https://doaj.org/article/d144b398a3054ae2ba43de1e5e05191d
Autor:
Elisabeth Orgler, Maximilian Baumgartner, Stefanie Duller, Christina Kumptisch, Bela Hausmann, Doris Moser, Vineeta Khare, Michaela Lang, Thomas Köcher, Adrian Frick, Markus Muttenthaler, Athanasios Makristathis, Christine Moissl-Eichinger, Christoph Gasche
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The gut microbiota has been implicated as a driver of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Recently we described, mucosal biofilms, signifying alterations in microbiota composition and bile acid (BA) metabolism in IBS
Externí odkaz:
https://doaj.org/article/26bffac2a9eb40418a42c4ac2a5d1048
Autor:
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B. Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F. Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W. Craven, Balazs R. Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J. Craik, Mariana Spetea, Tao Che, David Baker, Christian W. Gruber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an unmet challenge. Here, we
Externí odkaz:
https://doaj.org/article/1f201974b4984c89a23ccc2a9cfd522a
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The neuropeptide oxytocin (OT) regulates several peripheral and central functions and is a molecule of interest in psychiatric diseases such as autism spectrum disorder, schizophrenia, anxiety and depression. The study of OT in human serum samples is
Externí odkaz:
https://doaj.org/article/d96f3329174c41a686dda619f2eb0047
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5826-5833 (2021)
The neuropeptide vasopressin (VP) and its three G protein-coupled receptors (V1aR, V1bR and V2R) are of high interest in a wide array of drug discovery programs. V1aR is of particular importance due to its cardiovascular functions and diverse roles i
Externí odkaz:
https://doaj.org/article/0edf8daa77ee4c479910bae4c1543cc2
Autor:
Huiping Liu, Markus Muttenthaler
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1595 (2022)
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited treatment options and high mortality. The oxytocin receptor (OTR) is a class-A G protein-coupled receptor that has been linked to breast cancer, but its role in
Externí odkaz:
https://doaj.org/article/14afd148bff9475d9041dd070d23d20a
Autor:
Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2508 (2020)
TFF1 is a protective peptide of the Trefoil Factor Family (TFF), which is co-secreted with the mucin MUC5AC, gastrokine 2 (GKN2), and IgG Fc binding protein (FCGBP) from gastric surface mucous cells. Tff1-deficient mice obligatorily develop antropylo
Externí odkaz:
https://doaj.org/article/8aa5c0d2aff346d59da8d4e40e1134cd
Autor:
Volker Herzig, Aline Dantas de Araujo, Kathryn P. Greenwood, Yanni K.-Y. Chin, Monique J. Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham M. Nicholson, Paul F. Alewood, Glenn F. King
Publikováno v:
Biomedicines, Vol 6, Iss 3, p 90 (2018)
Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about potential lack of stability and oral bioactivity. We therefore systematically evaluated several syn
Externí odkaz:
https://doaj.org/article/376fa61b97e843a3b1e8372ffc8952b0
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32559 (2012)
Natural peptides of great number and diversity occur in all organisms, but analyzing their peptidome is often difficult. With natural product drug discovery in mind, we devised a genome-mining approach to identify defense- and neuropeptides in the ge
Externí odkaz:
https://doaj.org/article/3cee7db17cc74dfa945398453422a7a7
Publikováno v:
Nature Reviews Drug Discovery
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a08274cf93d6a15d28aee18b5f87e76
https://doi.org/10.1038/s41573-020-00135-8
https://doi.org/10.1038/s41573-020-00135-8