Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

Autor: Ruishu Deng, Christian Hurtz, Qingxiao Song, Chanyu Yue, Gang Xiao, Hua Yu, Xiwei Wu, Markus Muschen, Stephen Forman, Paul J. Martin, Defu Zeng

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a spe

Externí odkaz: https://doaj.org/article/4ae9ab1b935340a8a29b9c8d5a7b619c

Data from HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

Autor: Steven Grant, Markus Muschen, Nikhil Kolluri, Nguyen Nguyen, Nicholas Jordan, Lora Kramer, Elisa Attkisson, Yun Dai, Tri Nguyen

Purpose: The purpose of this study was to determine whether histone deacetylase (HDAC) inhibitors (HDACI) such as vorinostat or entinostat (SNDX-275) could increase the lethality of the dual Bcr/Abl-Aurora kinase inhibitor KW-2449 in various Bcr/Abl+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388f344a5f4ebea66d8d60af740c2d6c
https://doi.org/10.1158/1078-0432.c.6518106

Correction: Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer

Autor: Tamara Mirzapoiazova, Gang Xiao, Bolot Mambetsariev, Mohd W. Nasser, Emily Miaou, Sharad S. Singhal, Saumya Srivastava, Isa Mambetsariev, Michael S. Nelson, Arin Nam, Amita Behal, Leonidas D. Arvanitis, Pranita Atri, Markus Muschen, François L.H. Tissot, James Miser, John S. Kovach, Martin Sattler, Surinder K. Batra, Prakash Kulkarni, Ravi Salgia

Publikováno v: Molecular Cancer Therapeutics. 21:700-700

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::689f2dfcb8a343b5931daf99fe64ea96
https://doi.org/10.1158/1535-7163.mct-22-0104

Analysis of Ikaros tumor suppressor function in BCR-ABL1+pre-B ALL reveals conserved target genes and biological pathways

Autor: Hilde Schjerven, Etapong Fonabei Ayongaba, Jami McLaughlin, Donghui Cheng, Linn Margrethe Eggesbø, Ida Lindeman, Eugene Park, Owen N Witte, Stephen T Smale, Seth Frietze, Markus Muschen

Publikováno v: Schjerven, H; Ayongaba, EF; McLaughlin, J; Cheng, D; Eggesbo, LM; Lindeman, I; et al.(2016). Analysis of Ikaros tumor suppressor function in BCR-ABL1+pre-B ALL reveals conserved target genes and biological pathways. JOURNAL OF IMMUNOLOGY, 196. UCLA: Retrieved from: http://www.escholarship.org/uc/item/44b8557q
JOURNAL OF IMMUNOLOGY, vol 196
The Journal of Immunology, vol 196, iss 1_Supplement

Inactivation of the transcriptional factor Ikaros (IKZF1) correlates with poor prognosis in progenitor B-cell acute lymphoblastic leukemia (pre-B ALL), and is a hallmark of the BCR-ABL1+ subgroup of pre-B ALL. Ikaros is a critical regulator of hemato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aa76a705023d9180df8fd45d6140b2
http://www.escholarship.org/uc/item/44b8557q

STAT5 antagonism of B cell superenhancer networks initiates progenitor B cell leukemia and predicts patient survival (HEM1P.222)

Autor: Michael Farrar, Casey Katerndahl, Lynn Heltemes Harris, Mark Willette, christine Henzler, Rendong Yang, Kevin Silverstein, Seth Frietze, Hilde Schjerven, Laura Ramsey, Gregory Hubbard, Markus Muschen, Steven Kornblau

Publikováno v: The Journal of Immunology. 194:50.5-50.5

B cell Acute Lymphoblastic Leukemia (B-ALL) arises from the transformation of progenitor B cells. The transcription factor STAT5 is required for transformation but how STAT5 mediates this effect is unclear. Previous studies suggested that STAT5 only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93285cccd9dbb162001b5f547aa2217b
https://doi.org/10.4049/jimmunol.194.supp.50.5