Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Markus Muehlbacher"'
Autor:
Laura Guasch, Esther Sala, Anna Castell-Auví, Lidia Cedó, Klaus R Liedl, Gerhard Wolber, Markus Muehlbacher, Miquel Mulero, Montserrat Pinent, Anna Ardévol, Cristina Valls, Gerard Pujadas, Santiago Garcia-Vallvé
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50816 (2012)
BACKGROUND: Although there are successful examples of the discovery of new PPARγ agonists, it has recently been of great interest to identify new PPARγ partial agonists that do not present the adverse side effects caused by PPARγ full agonists. Co
Externí odkaz:
https://doaj.org/article/265703f2a5904960adfacc5fd9cc55e7
Autor:
Johannes Kornhuber, Markus Muehlbacher, Stefan Trapp, Stefanie Pechmann, Astrid Friedl, Martin Reichel, Christiane Mühle, Lothar Terfloth, Teja W Groemer, Gudrun M Spitzer, Klaus R Liedl, Erich Gulbins, Philipp Tripal
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23852 (2011)
We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to
Externí odkaz:
https://doaj.org/article/bd25bf066ec3473fbd19d8571dd669db
Autor:
Johannes Kornhuber, Markus Muehlbacher
Publikováno v:
RapidMiner ISBN: 9780429171093
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c43b7e7f047d4b960fa6201b885a88f
https://doi.org/10.1201/b16023-26
https://doi.org/10.1201/b16023-26
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 35
Drug-induced phospholipidosis (DIPLD), characterized by the accumulation of phospholipids within lysosomes, is suspected to impair lysosomal function and considered an adverse side effect of the administered medication. The increasing use of polyphar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89354c1a3f54935c861983196ccc0a7c
https://pubmed.ncbi.nlm.nih.gov/27221059
https://pubmed.ncbi.nlm.nih.gov/27221059
Publikováno v:
Chemmedchem
Drug-induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome. This adverse drug effect can occur in various tissues and is suspected to impact cellular viability. Therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6284860e9ac4675f360574f49b9d566
https://doi.org/10.1002/cmdc.201200306
https://doi.org/10.1002/cmdc.201200306
Publikováno v:
Sphingolipids: Basic Science and Drug Development ISBN: 9783709113677
Sphingolipids are not only structural components of biological membranes, but also play an important role in cellular signalling and, thus, are involved in cell proliferation and differentiation but also stress and cell death. It is therefore of grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647c12fe088b9ce0b6b94d0c153b2f54
https://doi.org/10.1007/978-3-7091-1368-4_9
https://doi.org/10.1007/978-3-7091-1368-4_9
Publikováno v:
Journal of chemical information and modeling. 51(9)
Quantitative structure-property relationships for predicting the water-octanol partition coefficient, logP(OW), are reported. The models are based on local properties calculated at the standard isodensity surface using semiempirical molecular orbital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c3ee0a129026bb28ad02b0225c763c
https://pubmed.ncbi.nlm.nih.gov/21842864
https://pubmed.ncbi.nlm.nih.gov/21842864
Autor:
Philipp Tripal, Cosima Rhein, Christiane Mühle, Martin Reichel, Markus Muehlbacher, Johannes Kornhuber, Teja W. Groemer, Erich Gulbins
Publikováno v:
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 26(1)
Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further degrades ceramide to sphingosine which can then be phosphorylated to sphingosine-1-phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c3cbb14ea152a37aa8d691704148e0
https://pubmed.ncbi.nlm.nih.gov/20502000
https://pubmed.ncbi.nlm.nih.gov/20502000
Autor:
Lídia Cedó, Laura Guasch, Esther Sala, Santiago Garcia-Vallvé, Gerard Pujadas, Markus Muehlbacher, Gerhard Wolber, Klaus R. Liedl, Cristina Valls, Montserrat Pinent, Miquel Mulero, Anna Ardévol, Anna Castell-Auví
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e50816 (2012)
PLoS ONE, Vol 7, Iss 11, p e50816 (2012)
BACKGROUND: Although there are successful examples of the discovery of new PPARγ agonists, it has recently been of great interest to identify new PPARγ partial agonists that do not present the adverse side effects caused by PPARγ full agonists. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6d4f8efd9e17bf2027d811cf4b2cb4
https://doi.org/10.1371/journal.pone.0050816
https://doi.org/10.1371/journal.pone.0050816
Publikováno v:
ChemMedChem. 7:1865-1865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb8de6d807e1e922bde6e823d95c041
https://doi.org/10.1002/cmdc.201290053
https://doi.org/10.1002/cmdc.201290053