Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Markus M. Xie"'
Autor:
Markus M. Xie, Alexander L. Dent
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma cells that secrete high-affinity and isotype-switched antibody (
Externí odkaz:
https://doaj.org/article/9888737041a6431cb23dc4821af5d7f7
Autor:
Markus M Xie, Alexander L. Dent
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617359
Antibodies produced by plasma cells are a major arm of adaptive immunity. Germinal center reactions that include germinal center B cells and follicular T cells are fundamental players for antibody production, particularly antigen specific antibodies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954bf1c589ef16d59530a573eba2d1c4
https://doi.org/10.1007/978-1-0716-1736-6_14
https://doi.org/10.1007/978-1-0716-1736-6_14
Autor:
Markus M, Xie, Alexander L, Dent
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2380
Antibodies produced by plasma cells are a major arm of adaptive immunity. Germinal center reactions that include germinal center B cells and follicular T cells are fundamental players for antibody production, particularly antigen specific antibodies.
Publikováno v:
Immunology & Cell Biology. 98:617-619
Shade et al. demonstrate that people with peanut allergies produce IgE antibodies that are enriched for sialic acid-containing glycoforms. The sialylated IgE triggered significantly more degranulation by basophils and mast cells, suggesting intrinsic
Autor:
Sheng Zhang, Vamsee Mallajosyula, Jeffrey M. Schapiro, Haley L. Dugan, Saborni Chakraborty, Catherine A. Blish, Gene S. Tan, Scott D. Boyd, Kari C. Nadeau, Taia T. Wang, Tho D. Pham, Robert Sherwood, Prasanna Jagannathan, Upinder Singh, Anthony S. Buzzanco, Jason R. Andrews, Tasha Morales, Patrick C. Wilson, Matthew J. Memoli, Nimish Kathale, Benjamin A. Pinsky, Susan Providenza, Cindy Buffone, Jeffery K. Taubenberger, Markus M. Xie, Joseph C. Gonzalez, Karlie Edwards
Publikováno v:
medRxiv
Nature Immunology
Nature immunology
Nature Immunology
Nature immunology
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a public health crisis that is exacerbated by our poor understanding of correlates of immunity. SARS-CoV-2 infection can cause Coronavirus Disease 2019 (COVI
Autor:
George S. Deepe, Jana Raynor, Jennifer T. Ingram, Ireti Ogunsulire, Alexander L. Dent, Allan J. Zajac, Sarah A. Hummel, Markus M. Xie, Christoph Hölscher, Senad Divanovic, Shibabrata Mukherjee, Claire Chougnet, Sing Sing Way, Harinder Singh, David A. Hildeman, Anna Malyshkina, Emily R. Miraldi, Ankur Saini, Theresa Alenghat, Maha Almanan
Publikováno v:
Science Advances
Elevated IL-10 in aged mice suppresses immune responses and has implications for vaccine nonresponsiveness in the elderly.
Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to
Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to
Autor:
Sanmei Hu, Anuradha Ray, Alexander L. Dent, Amanda C. Poholek, Markus M. Xie, Kun He, Sagar Laxman Kale, Angela Hettinga
Publikováno v:
The Journal of Experimental Medicine
The transcriptional repressor Blimp-1, known to constrain autoimmunity, is an unexpected and critical positive regulator of Th2 cells in the lung acting via an IL-10–STAT3 axis in response to inhaled allergens, driving pathophysiology associated wi
Autor:
Hao Wu, Jie Sun, Kristin Hollister, Byunghee Koh, Mark H. Kaplan, Alexander L. Dent, Markus M. Xie
Publikováno v:
European Journal of Immunology. 47:1136-1141
The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (TFH ) cells: Bcl6 promotes and Blimp1 inhibits TFH -cell differentiation. Similarly, Bcl6 activates, while Blimp1 represses, expression of th
Autor:
Kun He, Angela Hettinga, Sagar Laxman Kale, Sanmei Hu, Markus M. Xie, Alexander L. Dent, Anuradha Ray, Amanda C. Poholek
A Th2 immune response is central to allergic airway inflammation, which afflicts millions worldwide. However, the mechanisms that augment GATA3 expression in an antigen-primed developing Th2 cell are not well understood. Here, we describe an unexpect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98414a629860b06f6eda33a78df879b
https://doi.org/10.1101/766246
https://doi.org/10.1101/766246
Publikováno v:
JCI Insight. 4
T follicular regulatory (TFR) cells are found in the germinal center (GC) response and help shape the antibody (Ab) response. However, the precise role of TFR cells in the GC is controversial. Here, we addressed TFR cell function using mice with impa