Optogenetic Control of the Mitochondrial Protein Import in Mammalian Cells

Autor: Lukas F. J. Althoff, Markus M. Kramer, Benjamin Bührer, Denise Gaspar, Gerald Radziwill

Publikováno v: Cells, Vol 13, Iss 19, p 1671 (2024)

Mitochondria provide cells with energy and regulate the cellular metabolism. Almost all mitochondrial proteins are nuclear-encoded, translated on ribosomes in the cytoplasm, and subsequently transferred to the different subcellular compartments of mi

Externí odkaz: https://doaj.org/article/1aaccd2f648542118ee67864f93ccbd0

Shedding light on current trends in molecular optogenetics

Autor: Alexandra A.M. Fischer, Markus M. Kramer, Gerald Radziwill, Wilfried Weber

Publikováno v: Current opinion in chemical biology. 70

Molecular optogenetics is a highly dynamic research field. In the past two years, the field was characterized by the development of new allosteric switches as well as the forward integration of optogenetics research towards application. Further, two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6052463da4d08faaa7d2fc9e26d45e
https://pubmed.ncbi.nlm.nih.gov/35988347

Multichromatic Control of Signaling Pathways in Mammalian Cells

Autor: Gerald Radziwill, Markus M Kramer, Wignand W. D. Mühlhäuser, Wilfried Weber

Publikováno v: Advanced Biology. 5:2000196

The precise control of signaling proteins is a prerequisite to decipher the complexity of the signaling network and to reveal and to study pathways involved in regulating cellular metabolism and gene expression. Optogenetic approaches play an emergin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75ef1e307e7fab30f173cd23bbb5867
https://doi.org/10.1002/adbi.202000196

Bioinformatics-guided discovery of biaryl-linked lasso peptides.

Autor: Saad H; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen Auf der Morgenstelle 8 72076 Tübingen Germany hamada.saad@pharm.uni-tuebingen.de harald.gross@uni-tuebingen.de.; Department of Chemistry and the Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA., Majer T; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen Auf der Morgenstelle 8 72076 Tübingen Germany hamada.saad@pharm.uni-tuebingen.de harald.gross@uni-tuebingen.de., Bhattarai K; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen Auf der Morgenstelle 8 72076 Tübingen Germany hamada.saad@pharm.uni-tuebingen.de harald.gross@uni-tuebingen.de., Lampe S; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen Auf der Morgenstelle 8 72076 Tübingen Germany hamada.saad@pharm.uni-tuebingen.de harald.gross@uni-tuebingen.de., Nguyen DT; Department of Chemistry and the Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA., Kramer M; Institute of Organic Chemistry, University of Tübingen Auf der Morgenstelle 18 72076 Tübingen Germany., Straetener J; Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen Auf der Morgenstelle 28 72076 Tübingen Germany., Brötz-Oesterhelt H; Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen Auf der Morgenstelle 28 72076 Tübingen Germany.; Cluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, University of Tübingen Tübingen Germany., Mitchell DA; Department of Chemistry and the Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA., Gross H; Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen Auf der Morgenstelle 8 72076 Tübingen Germany hamada.saad@pharm.uni-tuebingen.de harald.gross@uni-tuebingen.de.; Cluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, University of Tübingen Tübingen Germany.

Publikováno v: Chemical science [Chem Sci] 2023 Oct 30; Vol. 14 (45), pp. 13176-13183. Date of Electronic Publication: 2023 Oct 30 (Print Publication: 2023).

Principles and Applications of CF 2 X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery.

Autor: Vaas S; Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Zimmermann MO; Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Schollmeyer D; Department of Chemistry, Johannes Gutenberg-Universität Mainz, 55099 Mainz, Germany., Stahlecker J; Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Engelhardt MU; Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Rheinganz J; Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Drotleff B; Pharmaceutical (Bio)Analysis, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Olfert M; Pharmaceutical (Bio)Analysis, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Lämmerhofer M; Pharmaceutical (Bio)Analysis, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Kramer M; Institute of Organic Chemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Stehle T; Interfaculty Institute of Biochemistry, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Boeckler FM; Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany.; Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Aug 10; Vol. 66 (15), pp. 10202-10225. Date of Electronic Publication: 2023 Jul 24.