Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Markus M Rinschen"'
Autor:
Nikolai Tschernoster, Florian Erger, Stefan Kohl, Björn Reusch, Andrea Wenzel, Stephen Walsh, Holger Thiele, Christian Becker, Marek Franitza, Malte P. Bartram, Martin Kömhoff, Lena Schumacher, Christian Kukat, Tatiana Borodina, Claudia Quedenau, Peter Nürnberg, Markus M Rinschen, Jan H. Driller, Bjørn P. Pedersen, Karl P. Schlingmann, Bruno Hüttel, Detlef Bockenhauer, Bodo Beck, Janine Altmüller
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Long-read sequencing is increasingly used to uncover structural variants in the human genome, both functionally neutral and deleterious. Structural variants occur more frequently in regions with a high homology or repetitive segme
Externí odkaz:
https://doaj.org/article/562f2d8f33f64894b552c46d64c66672
Autor:
Ola Al-Diab, Christin Sünkel, Eric Blanc, Rusan Ali Catar, Muhammad Imtiaz Ashraf, Hongfan Zhao, Pinchao Wang, Markus M. Rinschen, Raphaela Fritsche-Guenther, Florian Grahammer, Sebastian Bachmann, Dieter Beule, Jennifer A. Kirwan, Nikolaus Rajewsky, Tobias B. Huber, Dennis Gürgen, Angelika Kusch
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Sex differences exist in the prevalence and progression of major glomerular diseases. Podocytes are the essential cell-type in the kidney which maintain the physiological blood-urine barrier, and pathological changes in podocyte h
Externí odkaz:
https://doaj.org/article/6486c593796f4fa4bf8ff685f8544f3b
Autor:
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen
Externí odkaz:
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
Autor:
Wiebke Sachs, Lukas Blume, Desiree Loreth, Lisa Schebsdat, Favian Hatje, Sybille Koehler, Uta Wedekind, Marlies Sachs, Stephanie Zieliniski, Johannes Brand, Christian Conze, Bogdan I. Florea, Frank Heppner, Elke Krüger, Markus M. Rinschen, Oliver Kretz, Roland Thünauer, Catherine Meyer-Schwesinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Kidney filtration is ensured by the interaction of podocytes, endothelial and mesangial cells. Immunoglobulin accumulation at the filtration barrier is pathognomonic for glomerular injury. The mechanisms that regulate filter permeability are
Externí odkaz:
https://doaj.org/article/a86ad01a59e145d98cbb69c803c6d0ee
Autor:
Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M. Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the e
Externí odkaz:
https://doaj.org/article/0724fc4b52414f4ba1addf3e1cc01f23
Autor:
Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological
Externí odkaz:
https://doaj.org/article/2e9849a398d242b7a32232ec6d46f7d8
Autor:
Linda Reinhard, Thorsten Wiech, Aline Reitmeier, Moritz Lassé, Maya Machalitza, Asmus Heumann, Nicoletta Ferru, Desiree Loreth, Marie-Luise Schröder, Arvid Hutzfeldt, Felix R. Stahl, Sven Peine, Hermann-Josef Gröne, Catherine Meyer-Schwesinger, Markus M. Rinschen, Rolf A.K. Stahl, Elion Hoxha
Publikováno v:
Reinhard, L, Wiech, T, Reitmeier, A, Lassé, M, Machalitza, M, Heumann, A, Ferru, N, Loreth, D, Schröder, M-L, Hutzfeldt, A, Stahl, F R, Peine, S, Gröne, H-J, Meyer-Schwesinger, C, Rinschen, M M, Stahl, R A K & Hoxha, E 2023, ' Pathogenicity of Human anti-PLA2R1 Antibodies in Minipigs : A Pilot Study ', Journal of the American Society of Nephrology : JASN, vol. 34, no. 3, pp. 369-373 . https://doi.org/10.1681/ASN.0000000000000068
BACKGROUND: Primary membranous nephropathy (MN) is an autoimmune kidney disease in which immune complexes are deposited beneath the epithelium in the glomeruli. The condition introduces a high risk for end-stage kidney disease. Seventy to 80 percent
Autor:
Markus M. Rinschen, Markus Gödel, Florian Grahammer, Stefan Zschiedrich, Martin Helmstädter, Oliver Kretz, Mostafa Zarei, Daniela A. Braun, Sebastian Dittrich, Caroline Pahmeyer, Patricia Schroder, Carolin Teetzen, HeonYung Gee, Ghaleb Daouk, Martin Pohl, Elisa Kuhn, Bernhard Schermer, Victoria Küttner, Melanie Boerries, Hauke Busch, Mario Schiffer, Carsten Bergmann, Marcus Krüger, Friedhelm Hildebrandt, Joern Dengjel, Thomas Benzing, Tobias B. Huber
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2495-2508 (2018)
Summary: Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to p
Externí odkaz:
https://doaj.org/article/829b5109182743b5adae0c030affe4e5
Publikováno v:
Physiology. 38
Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors are new, highly effective drugs for treating type 2 diabetes mellitus. SGLT2 inhibitors also substantially reduced the risk of hospitalization for heart failure. Previous studies in rodents and humans
Autor:
Anne K. Mühlig, Johanna Steingröver, Hannah S. Heidelbach, Madelaine Wingerath, Wiebke Sachs, Irm Hermans-Borgmeyer, Catherine Meyer-Schwesinger, Hoon Young Choi, Beom Jin Lim, Christian Patry, Georg Friedrich Hoffmann, Nicole Endlich, Katharina Bracke, Mariella Weiß, Andreas H. Guse, Moritz Lassé, Markus M. Rinschen, Fabian Braun, Tobias B. Huber, Victor G. Puelles, Claus Peter Schmitt, Jun Oh
Publikováno v:
Mühlig, A K, Steingröver, J, Heidelbach, H S, Wingerath, M, Sachs, W, Hermans-Borgmeyer, I, Meyer-Schwesinger, C, Choi, H Y, Lim, B J, Patry, C, Hoffmann, G F, Endlich, N, Bracke, K, Weiß, M, Guse, A H, Lassé, M, Rinschen, M, Braun, F, Huber, T B, Puelles, V G, Schmitt, C P & Oh, J 2022, ' The Calcium-Sensing Receptor Stabilizes Podocyte Function in Proteinuric Humans and Mice ', Kidney International, vol. 101, no. 6, pp. 1186-1199 . https://doi.org/10.1016/j.kint.2022.01.036
Calcimimetic agents allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR), which is expressed in the tubular system and to a lesser extent in podocytes. Activation of this receptor can reduce glomerular proteinuri