Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Markus Latta"'
Autor:
Thomas Monfeuga, Jenny Norlin, Anne Bugge, Elisabeth D. Gaalsgaard, Cesar A. Prada-Medina, Markus Latta, Sanne S. Veidal, Pia S. Petersen, Michael Feigh, Dorte Holst
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101850- (2024)
Objective: The metabolic benefits of GLP-1 receptor (GLP-1R) agonists on glycemic and weight control are well established as therapy for type 2 diabetes and obesity. Glucagon's ability to increase energy expenditure is well described, and the combina
Externí odkaz:
https://doaj.org/article/b046605cf4e74e3997c9fe7753652fe9
Autor:
Josephine Skat-Rørdam, Kamilla Pedersen, Gry Freja Skovsted, Ida Gregersen, Sara Vangsgaard, David H. Ipsen, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 69 (2021)
Oxidative stress is directly linked to non-alcoholic fatty liver disease (NAFLD) and the progression to steaotohepatitis (NASH). Thus, a beneficial role of antioxidants in delaying disease progression and/or accelerating recovery may be expected, as
Externí odkaz:
https://doaj.org/article/09b18c39596d4a5484cb27b7f71e5b71
Autor:
Josephine Skat-Rørdam, David H. Ipsen, Stefan E. Seemann, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1198 (2021)
The successful development of effective treatments against nonalcoholic steatohepatitis (NASH) is significantly set back by the limited availability of predictive preclinical models, thereby delaying and reducing patient recovery. Uniquely, the guine
Externí odkaz:
https://doaj.org/article/c56d9914579c4057b728b4b8af90d4ef
Autor:
Vivian L de Oliveira, Romy R M C Keijsers, Peter C M van de Kerkhof, Marieke M B Seyger, Esther Fasse, Lars Svensson, Markus Latta, Hanne Norsgaard, Tord Labuda, Pieter Hupkens, Piet E J van Erp, Irma Joosten, Hans J P M Koenen
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45509 (2012)
Humanized mouse models offer a challenging possibility to study human cell function in vivo. In the huPBL-SCID-huSkin allograft model human skin is transplanted onto immunodeficient mice and allowed to heal. Thereafter allogeneic human peripheral blo
Externí odkaz:
https://doaj.org/article/ac14bfdebdd84d2491d0554f1db844c7
Autor:
Jens Lykkesfeldt, Stefan E. Seemann, Pernille Tveden-Nyborg, Josephine Skat-Rørdam, Markus Latta, David Højland Ipsen
Publikováno v:
Biomedicines
Biomedicines; Volume 9; Issue 9; Pages: 1198
Biomedicines, Vol 9, Iss 1198, p 1198 (2021)
Skat-rørdam, J, Ipsen, D H, Seemann, S E, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model ', Biomedicines, vol. 9, no. 9, 1198 . https://doi.org/10.3390/biomedicines9091198
Biomedicines; Volume 9; Issue 9; Pages: 1198
Biomedicines, Vol 9, Iss 1198, p 1198 (2021)
Skat-rørdam, J, Ipsen, D H, Seemann, S E, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model ', Biomedicines, vol. 9, no. 9, 1198 . https://doi.org/10.3390/biomedicines9091198
The successful development of effective treatments against nonalcoholic steatohepatitis (NASH) is significantly set back by the limited availability of predictive preclinical models, thereby delaying and reducing patient recovery. Uniquely, the guine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167525fe4495009d823290e51114b81f
https://pubmed.ncbi.nlm.nih.gov/34572384
https://pubmed.ncbi.nlm.nih.gov/34572384
Autor:
Patrick Duncan Hardam, Josephine Skat-Rørdam, Markus Latta, David Højland Ipsen, Jens Lykkesfeldt, Pernille Tveden-Nyborg
Publikováno v:
Nutrients
Volume 13
Issue 8
Skat-rørdam, J, Ipsen, D H, Hardam, P D, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Differential effects of dietary components on glucose intolerance and non-alcoholic steatohepatitis ', Nutrients, vol. 13, no. 8, 2523 . https://doi.org/10.3390/nu13082523
Nutrients, Vol 13, Iss 2523, p 2523 (2021)
Volume 13
Issue 8
Skat-rørdam, J, Ipsen, D H, Hardam, P D, Latta, M, Lykkesfeldt, J & Tveden-nyborg, P 2021, ' Differential effects of dietary components on glucose intolerance and non-alcoholic steatohepatitis ', Nutrients, vol. 13, no. 8, 2523 . https://doi.org/10.3390/nu13082523
Nutrients, Vol 13, Iss 2523, p 2523 (2021)
Pharmacological treatment modalities for non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are scarce, and discoveries are challenged by lack of predictive animal models adequately reflecting severe human disease stages and co-morb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85198630342b34be12bf4641b0b95609
Autor:
Michael Feigh, Jenny Norlin, James L. Trevaskis, Nora E. Zois, Diego A. Miranda, Markus Latta, Jamie G. Bates, Sanne Skovgård Veidal
Publikováno v:
Diabetes. 69
Combination approaches for the treatment of NASH are being actively pursued. We examined the effects of administration of a dual GLP-1 and glucagon receptor agonist (GLP-1:GCG, 0.015 mg/kg, s.c., q.d.) alone and combined with an FXR agonist (cilofexo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53519e387d9487bc90d66fc1eb48dced
https://doi.org/10.2337/db20-1813-p
https://doi.org/10.2337/db20-1813-p
Autor:
James L. Trevaskis, Diego A. Miranda, Michael Feigh, Jenny Norlin, Sanne Skovgård Veidal, Markus Latta, Jamie G. Bates, Nora E. Zois
Publikováno v:
Diabetes. 69
Semaglutide (SEMA), FXR agonists and ACC inhibitors are under active clinical investigation for the treatment of NASH. Here, we explored whether the effects of SEMA (0.12 mg/kg, s.c., q.d.) on NASH endpoints could be enhanced by addition of an FXR ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24d6d3f1ca0d092a1f0ee487c4be0293
https://doi.org/10.2337/db20-1810-p
https://doi.org/10.2337/db20-1810-p
Autor:
Elisabeth D. Galsgaard, Henrik D. Pedersen, Berit Østergaard Christoffersen, Merete Fredholm, Markus Latta, Dorte Holst, Susanna Cirera
Publikováno v:
Journal of Clinical and Experimental Hepatology
Pedersen, H D, Galsgaard, E D, Christoffersen, B, Cirera, S, Holst, D, Fredholm, M & Latta, M 2020, ' NASH-inducing Diets in Göttingen Minipigs ', Journal of Clinical and Experimental Hepatology, vol. 10, no. 3, pp. 211-221 . https://doi.org/10.1016/j.jceh.2019.09.004
Pedersen, H D, Galsgaard, E D, Christoffersen, B, Cirera, S, Holst, D, Fredholm, M & Latta, M 2020, ' NASH-inducing Diets in Göttingen Minipigs ', Journal of Clinical and Experimental Hepatology, vol. 10, no. 3, pp. 211-221 . https://doi.org/10.1016/j.jceh.2019.09.004
Background Owing to the human-like physiology, a minipig model of nonalcoholic steatohepatitis (NASH) could be valuable. Pigs, however, rarely develop substantial hepatic steatosis, even when fed diets with high fat, fructose, and cholesterol (FFC) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05e1f5726ee082ed2c5c2d742ea87d1
https://pubmed.ncbi.nlm.nih.gov/32405177
https://pubmed.ncbi.nlm.nih.gov/32405177
Autor:
Josephine Skat-Rørdam, Pernille Tveden-Nyborg, Jens Lykkesfeldt, Markus Latta, David Højland Ipsen, Maria Malvina Tsamouri
Publikováno v:
Molecular genetics and genomics : MGG. 294(3)
Hepatic fibrosis increases mortality in humans with non-alcoholic steatohepatitis (NASH), but it remains unclear how fibrosis stage and progression affect the pathogenic mechanisms of NASH. This study investigates the transcriptional regulation and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de6fa181b0808855c9d6718a46fa933
https://pubmed.ncbi.nlm.nih.gov/30759275
https://pubmed.ncbi.nlm.nih.gov/30759275