Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Markus Löbrich"'
Autor:
Lara Kim Brackmann, Ronja Foraita, Heike Schwarz, Danuta Galetzka, Sebastian Zahnreich, Thomas Hankeln, Markus Löbrich, Alicia Poplawski, Desiree Grabow, Maria Blettner, Heinz Schmidberger, Manuela Marron
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundImproved treatments for childhood cancer result in a growing number of long-term childhood cancer survivors (CCS). The diagnosis and the prevalence of comorbidities may, however, influence their lifestyle later in life. Nonetheless, little
Externí odkaz:
https://doaj.org/article/054fee3b7dcc4daaa9db0184535848e8
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be re
Externí odkaz:
https://doaj.org/article/f7bfb44500064bbfab5f9926b917f7c1
Autor:
Amira Elbakry, Markus Löbrich
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Homologous recombination (HR) is an essential pathway for DNA double-strand break (DSB) repair, which can proceed through various subpathways that have distinct elements and genetic outcomes. In this mini-review, we highlight the main features known
Externí odkaz:
https://doaj.org/article/769390352f2347479663bca9768257ad
Autor:
Sebastian Zahnreich, Alicia Poplawski, Carola Hartel, Lukas Stefan Eckhard, Danuta Galetzka, Thomas Hankeln, Markus Löbrich, Manuela Marron, Johanna Mirsch, Sylvia Ritter, Peter Scholz-Kreisel, Claudia Spix, Heinz Schmidberger
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The purpose of the present study was to investigate whether former childhood cancer patients who developed a subsequent secondary primary neoplasm (SPN) are characterized by elevated spontaneous chromosomal instability or cellular and chromosomal rad
Externí odkaz:
https://doaj.org/article/b5624724e6504bdd994eb7dff60a12a0
Autor:
Isabel Freund, Stephanie Hehlgans, Daniel Martin, Michael Ensminger, Emmanouil Fokas, Claus Rödel, Markus Löbrich, Franz Rödel
Publikováno v:
Cells, Vol 9, Iss 5, p 1235 (2020)
NIMA (never-in-mitosis gene A)-related kinase 1 (Nek1) is shown to impact on different cellular pathways such as DNA repair, checkpoint activation, and apoptosis. Its role as a molecular target for radiation sensitization of malignant cells, however,
Externí odkaz:
https://doaj.org/article/e98b33590b1545048ede298a07fe41bd
Autor:
Florian Frohns, Antonia Frohns, Johanna Kramer, Katharina Meurer, Carla Rohrer-Bley, Irina Solovei, David Hicks, Paul G. Layer, Markus Löbrich
Publikováno v:
Cells, Vol 9, Iss 4, p 947 (2020)
Genome editing (GE) represents a powerful approach to fight inherited blinding diseases in which the underlying mutations cause the degeneration of the light sensing photoreceptor cells of the retina. Successful GE requires the efficient repair of DN
Externí odkaz:
https://doaj.org/article/b31ba800eff94d228acaaf28bea802ce
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 5 (2018)
Chromatin remodeling is critical for the regulation of the DNA damage response. We highlight findings from our recent study showing that the deposition of the histone variant H3.3 by the alpha-thalassemia mental retardation X-linked protein (ATRX) an
Externí odkaz:
https://doaj.org/article/d9c5afd83c454a02b1027a6f7e8a658d
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003667 (2013)
Non-homologous end-joining (NHEJ) and homologous recombination (HR) represent the two main pathways for repairing DNA double-strand breaks (DSBs). During the G2 phase of the mammalian cell cycle, both processes can operate and chromatin structure is
Externí odkaz:
https://doaj.org/article/2532d478ea6d46fa84b2b29477db844c
Supplementary Figure 1 from ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c8f1410c21665a72fbe68176f52071
https://doi.org/10.1158/0008-5472.22363565.v1
https://doi.org/10.1158/0008-5472.22363565.v1
Supplementary Methods, Figure Legends 1-4 from The Limitations of the G1-S Checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3281d5e86a36b0db00a4823c1035d2cf
https://doi.org/10.1158/0008-5472.22382066.v1
https://doi.org/10.1158/0008-5472.22382066.v1