The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease

Autor: Selma M. Soyal, Greta Zara, Boris Ferger, Thomas K. Felder, Markus Kwik, Charity Nofziger, Silvia Dossena, Christine Schwienbacher, Andrew A. Hicks, Peter P. Pramstaller, Markus Paulmichl, Serge Weis, Wolfgang Patsch

Publikováno v: Neurobiology of Disease, Vol 121, Iss , Pp 34-46 (2019)

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. PGC-1α, encoded by PPARGC1A, is a transcriptional co-activator that has been implicated in the pathogenesis of neurodegenerative disorders. We recently discovere

Externí odkaz: https://doaj.org/article/3d8930f29f0b4486b09fe7e92a0b475c

Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases

Autor: Markus Kwik, Stefan Hainzl, Jan Oppelt, Boris Tichy, Ulrich Koller, Emanuele Bernardinelli, Markus Steiner, Greta Zara, Charity Nofziger, Serge Weis, Markus Paulmichl, Silvia Dossena, Wolfgang Patsch, Selma M. Soyal

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7, p 3296 (2021)

The transcriptional regulator peroxisome proliferator activated receptor gamma coactivator 1A (PGC-1α), encoded by PPARGC1A, has been linked to neurodegenerative diseases. Recently discovered CNS-specific PPARGC1A transcripts are initiated far upstr

Externí odkaz: https://doaj.org/article/46c4e45c19ba46d1b98f3e9f3b1a9a0c

The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease

Autor: Selma M. Soyal, Greta Zara, Boris Ferger, Thomas K. Felder, Markus Kwik, Charity Nofziger, Silvia Dossena, Christine Schwienbacher, Andrew A. Hicks, Peter P. Pramstaller, Markus Paulmichl, Serge Weis, Wolfgang Patsch

Publikováno v: Neurobiology of Disease, Vol 121, Iss, Pp 34-46 (2019)

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. PGC-1α, encoded by PPARGC1A, is a transcriptional co-activator that has been implicated in the pathogenesis of neurodegenerative disorders. We recently discovere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1be7c8a8a5ca49c81c5dbf1501f385aa
https://pubmed.ncbi.nlm.nih.gov/30236862

Functional Testing of SLC26A4 Variants--Clinical and Molecular Analysis of a Cohort with Enlarged Vestibular Aqueduct from Austria.

Autor: Roesch, Sebastian¹ s.roesch@salk.at, Bernardinelli, Emanuele² e.bernardinelli@pmu.ac.at, Nofziger, Charity³ charity.nofziger@me.com, Tóth, Miklós⁴ m.toth@uke.de, Patsch, Wolfgang², Rasp, Gerd¹, Paulmichl, Markus⁵ paulmichl@me.com, Dossena, Silvia² s.roesch@salk.at

Publikováno v: International Journal of Molecular Sciences. Jan2018, Vol. 19 Issue 1, p209. 22p. 3 Charts, 6 Graphs.

Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases.

Autor: Kwik, Markus¹ (AUTHOR) markus.kwik@live.at, Hainzl, Stefan² (AUTHOR) s.hainzl@salk.at, Oppelt, Jan^3,4 (AUTHOR) jan.oppelt@mail.muni.cz, Tichy, Boris³ (AUTHOR) boris.tichy@ceitek.muni.cz, Koller, Ulrich² (AUTHOR) u.koller@salk.at, Bernardinelli, Emanuele¹ (AUTHOR) e.bernardinelli@pmu.ac.at, Steiner, Markus⁵ (AUTHOR) mark.steiner@salk.at, Zara, Greta¹ (AUTHOR) gzara@coh.org, Nofziger, Charity⁶ (AUTHOR) charity.nofziger@pharmgenetix.com, Weis, Serge⁷ (AUTHOR) serge.weis@kepleruniklinikum.at, Paulmichl, Markus⁸ (AUTHOR) paulmichl@me.com, Dossena, Silvia¹ (AUTHOR) silvia.dossena@pmu.ac.at, Patsch, Wolfgang¹ (AUTHOR) wolfgang.patsch@pmu.ac.at, Soyal, Selma M.¹ (AUTHOR) wolfgang.patsch@pmu.ac.at, Cordaro, Marika (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Apr2021, Vol. 22 Issue 7, p3296. 1p.