Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Markus Kaller"'
Publikováno v:
Cancer Communications, Vol 44, Iss 3, Pp 433-437 (2024)
Externí odkaz:
https://doaj.org/article/569443f5f1cf4b1088c6eb4c6dbe0c62
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-24 (2022)
Abstract Background AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. Here, we set out to determine the relevance of AP4 in human colore
Externí odkaz:
https://doaj.org/article/5ae01414ce1b46b9880768fe58ae7217
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 391-418 (2020)
Background & Aims: The miR-34a gene is a direct target of p53 and is commonly silenced in colorectal cancer (CRC). Here we identified the receptor tyrosine kinase CSF1R as a direct miR-34a target and characterized CSF1R as an effector of p53/miR-34a-
Externí odkaz:
https://doaj.org/article/52278c3e5115469e9f3f4a23f8d6d48f
Autor:
Stephanie Jaeckel, Markus Kaller, Rene Jackstadt, Ursula Götz, Susanna Müller, Sophie Boos, David Horst, Peter Jung, Heiko Hermeking
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The c-MYC oncoprotein has many targets whose actions are not fully understood including TFAP4/AP4. Here, the authors show in a mouse model of inherited colorectal cancer that deletion of AP4 decreased the frequency of c-MYC-driven intestinal adenomas
Externí odkaz:
https://doaj.org/article/c22477ac99a148f3b0a8d972d65afea8
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Epithelial-mesenchymal transition (EMT) plays an important role in tumor invasion and metastasis. A comprehensive, bioinformatics analysis of CCLE and TCGA datasets of seven tumor types allowed us to identify a novel pan-cancer EMT-associate
Externí odkaz:
https://doaj.org/article/688cc78b6434435a850ee3cdf62c3d60
Autor:
Camille Du Roure, Aude Versavel, Thierry Doll, Chun Cao, Vincent Pillonel, Gabriele Matthias, Markus Kaller, Jean-François Spetz, Patrick Kopp, Hubertus Kohler, Matthias Müller, Patrick Matthias
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92836 (2014)
We have identified expression of the gene encoding the transcriptional coactivator FOG-1 (Friend of GATA-1; Zfpm1, Zinc finger protein multitype 1) in B lymphocytes. We found that FOG-1 expression is directly or indirectly dependent on the B cell-spe
Externí odkaz:
https://doaj.org/article/266c2f1d15bb468ca19884f79e7c60d4
Autor:
David Horst, Thomas Kirchner, Thomas G.P. Grünewald, Heiko Hermeking, Andreas Jung, Jutta Engel, Tobias S. Schiergens, Cristina Blaj, Eva Marina Schmidt, Markus Kaller, Sebastian Lamprecht
Purpose: Colorectal cancers are composed of phenotypically different tumor cell subpopulations within the same core genetic background. Here, we identify high expression of the TALE transcription factor PBX3 in tumor cells undergoing epithelial–mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00f9816d3025281797de3046786c8c7
https://doi.org/10.1158/1078-0432.c.6525713
https://doi.org/10.1158/1078-0432.c.6525713
Autor:
David Horst, Thomas Kirchner, Thomas G.P. Grünewald, Heiko Hermeking, Andreas Jung, Jutta Engel, Tobias S. Schiergens, Cristina Blaj, Eva Marina Schmidt, Markus Kaller, Sebastian Lamprecht
Figure S1. Specificity of PBX3 protein detection. Figure S2. Effects of WNT repression on PBX3 in colon cancer cells. Figure S3. Lack of transcriptional regulation of PBX3 expression by WNT. Figure S4. Effects of EMT induction with a conditional ZEB1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a75b5db6e77e427f5dba6503c12b042
https://doi.org/10.1158/1078-0432.22464416.v1
https://doi.org/10.1158/1078-0432.22464416.v1
Autor:
Fangteng Liu, Nassim Bouznad, Markus Kaller, Xiaolong Shi, Janine König, Stephanie Jaeckel, Heiko Hermeking
Publikováno v:
International Journal of Biological Sciences. 18:5415-5437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3322f9709d4492a94d151803ebe6c44b
https://doi.org/10.7150/ijbs.75503
https://doi.org/10.7150/ijbs.75503
Publikováno v:
Cancers
Volume 15
Issue 4
Pages: 1162
Volume 15
Issue 4
Pages: 1162
Background: The deregulated expression of the c-MYC oncogene activates p53, which is presumably mediated by ARF/INK4, as well as replication-stress-induced DNA damage. Here, we aimed to determine whether the c-MYC-inducible AP4 transcription factor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33384faa1a82c242b77745beec1eaf4f