Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Markus Kalesse"'
Autor:
Sebastian Roman Borgert, Steffi Henke, Florian Witzgall, Stefan Schmelz, Susanne zur Lage, Sven-Kevin Hotop, Steffi Stephen, Dennis Lübken, Jonas Krüger, Nicolas Oswaldo Gomez, Marco van Ham, Lothar Jänsch, Markus Kalesse, Andreas Pich, Mark Brönstrup, Susanne Häussler, Wulf Blankenfeldt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three intertwined quorum sensing systems control virulence of P. aeruginosa,
Externí odkaz:
https://doaj.org/article/0f0b91a8c4f34e998f22e33116f8f4b6
Autor:
Jan Geldsetzer, Markus Kalesse
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 670-673 (2020)
The stereoselective synthesis of the (Z)-enamide fragment of chondrochloren (1) is described. A Buchwald-type coupling between amide 3 and (Z)-bromide 4 was used to generate the required fragment. The employed amide 3 comprising three chiral centers
Externí odkaz:
https://doaj.org/article/7f86397b3c85487e8881d7116d18bc5e
Publikováno v:
Molecules, Vol 25, Iss 17, p 3841 (2020)
Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs o
Externí odkaz:
https://doaj.org/article/919aee2f193047a4855e5de4ed12b64b
Autor:
Martin Cordes, Markus Kalesse
Publikováno v:
Molecules, Vol 24, Iss 17, p 3040 (2019)
It is a challenging objective in synthetic organic chemistry to create efficient access to biologically active compounds. In particular, one structural element which is frequently incorporated into the framework of complex natural products is a β-hy
Externí odkaz:
https://doaj.org/article/ad894543dad84787b6679d2a55769d84
Publikováno v:
Journal of the American Chemical Society. 145:7021-7029
Publikováno v:
JACS Au.
Autor:
Markus Kalesse, Daniel Lücke
Publikováno v:
Synlett. 33:1117-1122
Here we present our work on a Kiyooka aldol protocol for the stereoselective synthesis of tertiary alcohols. In the obtained products, three oxygenated carbon atoms that could further be differentiated flank the chiral tertiary alcohol. This methodol
Publikováno v:
European journal of organic chemistry 2022 (2022), Nr. 41
European journal of organic chemistry
European journal of organic chemistry
Photochemical, sigmatropic 1,3-acyl shifts represent a powerful tool to construct quaternary carbon atoms and the backbones of complex natural products which cannot be constructed easily by conventional methods. This review highlights applications of
Publikováno v:
Synthesis. 54:975-998
The Diels–Alder reaction has long been established as an extremely useful procedure in the toolbox of natural product chemists. It tolerates a wide spectrum of building blocks of different complexity and degrees of derivatization, and enables the f
Publikováno v:
Angewandte Chemie (International ed. in English)
Germany
Angewandte Chemie (International Ed. in English)
Germany
Angewandte Chemie (International Ed. in English)
The first total synthesis of chondrochloren A is accomplished using a 1,2‐metallate rearrangement addition as an alternative for the Nozaki‐Hiyama‐Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segmen