Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Markus Jeschek"'
Autor:
Tobias Vornholt, Mojmír Mutný, Gregor W. Schmidt, Christian Schellhaas, Ryo Tachibana, Sven Panke, Thomas R. Ward, Andreas Krause, Markus Jeschek
Publikováno v:
ACS Central Science, Vol 10, Iss 7, Pp 1357-1370 (2024)
Externí odkaz:
https://doaj.org/article/f8b59a92beff4ae0999ef4f4f761392a
Autor:
Simon Höllerer, Laetitia Papaxanthos, Anja Cathrin Gumpinger, Katrin Fischer, Christian Beisel, Karsten Borgwardt, Yaakov Benenson, Markus Jeschek
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Current methods to generate sequence-function data at large scale are either technically complex or limited to specific applications. Here the authors introduce DNA-based phenotypic recording to overcome these limitations and enable deep learning for
Externí odkaz:
https://doaj.org/article/5cdab11544394bd78e7fc3880bbaa8e2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Cycloalkenes are bulk petrochemicals that are currently obtained from fossil fuels. Here, the authors developed multi enzyme pathways in combination with a Ru-catalyzed metathesis reaction for the one-pot production of cyclopentene, cyclohexene, and
Externí odkaz:
https://doaj.org/article/d91a0bf2fa974208a03b8ea4649a888e
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway op
Externí odkaz:
https://doaj.org/article/e9c8e8a8f07c4ecbac79a4d985f6ac3a
Autor:
Anja C Gumpinger, Karsten M. Borgwardt, Christian Beisel, Katrin Fischer, Laetitia Papaxanthos, Markus Jeschek, Yaakov Benenson, Simon Hoellerer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, 11 (1)
Nature Communications
Nature Communications, 11 (1)
Predicting effects of gene regulatory elements (GREs) is a longstanding challenge in biology. Machine learning may address this, but requires large datasets linking GREs to their quantitative function. However, experimental methods to generate such d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924dd0ac979d603ba9dd553fdd6f2237
https://doaj.org/article/5cdab11544394bd78e7fc3880bbaa8e2
https://doaj.org/article/5cdab11544394bd78e7fc3880bbaa8e2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications, 10
Nature Communications
Nature Communications, 10
Engineered enzyme cascades offer powerful tools to convert renewable resources into value-added products. Man-made catalysts give access to new-to-nature reactivities that may complement the enzyme’s repertoire. Their mutual incompatibility, howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fac62c024eb2c5ab23cb6c45c97922
https://doaj.org/article/d91a0bf2fa974208a03b8ea4649a888e
https://doaj.org/article/d91a0bf2fa974208a03b8ea4649a888e
Autor:
Sven Panke, Markus Jeschek, Michela M. Pellizzoni, Thomas R. Ward, Fadri Christoffel, Tobias Vornholt
Publikováno v:
bioRxiv
Science Advances, 7 (4)
Science Advances, 7 (4)
Artificial metalloenzymes (ArMs) catalyzing new-to-nature reactions could play an important role in transitioning toward a sustainable economy. While ArMs have been created for various transformations, attempts at their genetic optimization have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e540f0438edc4327d504695d6dd04a8c
Publikováno v:
Trends in Biotechnology, 36 (1)
Residing at the interface of chemistry and biotechnology, artificial metalloenzymes offer an attractive technology to combine the versatile reaction repertoire of transition metal catalysts with the exquisite catalytic features of enzymes. While earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afef1d98bd64094c9c9ff79648d87fe6
Autor:
Eszter Csibra, Tillmann Heinisch, Brett Garabedian, Philippe Marlière, Thomas R. Ward, Sven Panke, Jaicy Vallapurackal, Fabian Schwizer, Vitor B. Pinheiro, Markus Jeschek
Publikováno v:
Chemical Science, 9 (24)
Chemical Science
Chemical Science
Artificial metalloenzymes (ArMs hereafter) combine attractive features of both homogeneous catalysts and enzymes and offer the potential to implement new-to-nature reactions in living organisms. Herein we present an E. coli surface display platform f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e06eab82ccacf8b7e91c3a9ee6660c
https://edoc.unibas.ch/70533/
https://edoc.unibas.ch/70533/
Publikováno v:
Current Opinion in Biotechnology, 47
Elimination of metabolic flux imbalances in microbial cell factories is an important part in the establishment of viable biotechnological production processes. However, due to the high complexity of cellular metabolism, the limited a priori knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625bf20659b19d04d15d1d8e3db83d4f
https://hdl.handle.net/20.500.11850/371013
https://hdl.handle.net/20.500.11850/371013