Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Markus J. Leskinen"'
Autor:
Soili Lätti, Markus J. Leskinen, Ken A. Lindstedt, Petri T. Kovanen, Jukka K. Hakala, Hanna M. Heikkilä
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:309-314
Objective— Activated mast cells (MCs) induce endothelial cell (EC) apoptosis in vitro and are present at sites of plaque erosions in vivo. To further elucidate the role of MCs in endothelial apoptosis and consequently in plaque erosion, we have stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db77a81fd7e2db488c52ae1ebfcf3551
https://doi.org/10.1161/atvbaha.107.151340
https://doi.org/10.1161/atvbaha.107.151340
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 24:1350-1358
The 2 major general concepts about the cell biology of atherogenesis, growth of smooth muscle cells, and lipid accumulation in macrophages, ie, foam cell formation, have not been able to satisfactorily explain the genesis of acute coronary syndromes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15efcdc580bdead8b0548dd56ce200de
https://doi.org/10.1161/01.atv.0000135322.78008.55
https://doi.org/10.1161/01.atv.0000135322.78008.55
Publikováno v:
Biochemical Pharmacology. 66:1493-1498
The fibrous cap of a lipid-containing atherosclerotic plaque consists of collagen produced by arterial smooth muscle cells (SMCs) of synthetic phenotype. A thick cap protects the lipid-rich core, whereas a thin cap predisposes it to rupture, with ens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c77608f93aaa05f547b0e9690e8918a
https://doi.org/10.1016/s0006-2952(03)00503-3
https://doi.org/10.1016/s0006-2952(03)00503-3
Autor:
Soili Lätti, Yenfeng Wang, Markus J. Leskinen, Petri T. Kovanen, Naotaka Shiota, Ken A. Lindstedt
Publikováno v:
Journal of Cellular Physiology. 195:130-138
Degranulated mast cells are present in the subendothelial space of eroded (de-endothelialized) coronary atheromas. Upon degranulation, mast cells secrete into the surrounding tissue an array of preformed and newly synthesized mediators, including pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e73b721313df4c7164391e0bb5ff8dd8
https://doi.org/10.1002/jcp.10235
https://doi.org/10.1002/jcp.10235
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 21:1928-1933
Abstract — In the vulnerable areas of fibrous caps of advanced atherosclerotic lesions, chymase-containing mast cells are present. In such areas, the numbers of smooth muscle cells (SMCs) and the content of collagen are reduced. In this in vitro st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8ef3fc02ce1d04774cff7f318c1d57
https://doi.org/10.1161/hq1201.100227
https://doi.org/10.1161/hq1201.100227
Autor:
Ken A. Lindstedt, Markus J. Leskinen, Timo Sorsa, Kari K. Eklund, Petri T. Kovanen, Lorne M. Golub
Publikováno v:
Coronary artery disease. 18(8)
INTRODUCTION Chemically modified tetracyclines (CMTs) are a group of nonantimicrobial derivatives of tetracycline, which exert antiproliferative and anticollagenolytic properties. The molecular mechanisms, however, are poorly understood. MATERIALS AN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b64443ddfec204c1016afd31d37200c
https://pubmed.ncbi.nlm.nih.gov/18004118
https://pubmed.ncbi.nlm.nih.gov/18004118
Autor:
Jukka K. Hakala, Markus J. Leskinen, Ken A. Lindstedt, Hanna M. Heikkilä, Mika Laine, Mei Y. Speer, Petri T. Kovanen
Publikováno v:
Experimental cell research. 312(8)
Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eaecb95f84a2c855814a0fe7872316
https://pubmed.ncbi.nlm.nih.gov/16460729
https://pubmed.ncbi.nlm.nih.gov/16460729
Autor:
Ken A. Lindstedt, A Juurikivi, Kari K. Eklund, Tiina Mäki, Petri T. Kovanen, Markus J. Leskinen, Charlotta Sandler, T. Juutilainen
Background: Mast cells have been implicated in the pathogenesis of arthritis, but elucidation of their precise role has been hampered by a lack of efficient and selective inhibitors of their function. Objective: To elucidate the role of mast cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2269fcd98887193de363a8197d7b91d
https://europepmc.org/articles/PMC1755598/
https://europepmc.org/articles/PMC1755598/
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 23(2)
Objective— Chymase released from activated mast cells has been shown to induce apoptosis of vascular smooth muscle cells (SMCs) in vitro. The proteolytic activity of chymase is essential for the proapoptotic effect, but the mechanism of chymase-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0425388e8508d239d7fc2c39ac2a5f
https://pubmed.ncbi.nlm.nih.gov/12588765
https://pubmed.ncbi.nlm.nih.gov/12588765