Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Markus Jähnert"'
Autor:
Georgia Lenihan‐Geels, Francisco Garcia Carrizo, Marina Leer, Sabrina Gohlke, Moritz Oster, Sophie Pöhle‐Kronawitter, Christiane Ott, Alexandra Chadt, Isabel N. Reinisch, Markus Galhuber, Chen Li, Wenke Jonas, Markus Jähnert, Susanne Klaus, Hadi Al‐Hasani, Tilman Grune, Annette Schürmann, Tobias Madl, Andreas Prokesch, Michael Schupp, Tim J. Schulz
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1772-1784 (2024)
Abstract Background The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development
Externí odkaz:
https://doaj.org/article/6dc15b690f604a70b8d64e36ef498037
Autor:
Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J. Fazakerley, Heike Vogel
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102014- (2024)
Objective: Picalm (phosphatidylinositol-binding clathrin assembly protein), a ubiquitously expressed clathrin-adapter protein, is a well-known susceptibility gene for Alzheimer's disease, but its role in white adipose tissue (WAT) function has not ye
Externí odkaz:
https://doaj.org/article/e91ee5beb1f043a1b62ff3f522be0fb8
Autor:
Ye Cao, Masaya Araki, Yoshimi Nakagawa, Luisa Deisen, Annemarie Lundsgaard, Josephine M. Kanta, Stephanie Holm, Kornelia Johann, Jens Christian Brings Jacobsen, Markus Jähnert, Annette Schürmann, Bente Kiens, Christoffer Clemmensen, Hitoshi Shimano, Andreas M. Fritzen, Maximilian Kleinert
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101991- (2024)
Objective: Dietary medium-chain fatty acids (MCFAs), characterized by chain lengths of 8–12 carbon atoms, have been proposed to have beneficial effects on glucose and lipid metabolism, yet the underlying mechanisms remain elusive. We hypothesized t
Externí odkaz:
https://doaj.org/article/a73423385e39458e84871af2e20ee693
Autor:
Meriem Ouni, Fabian Eichelmann, Markus Jähnert, Christin Krause, Sophie Saussenthaler, Christiane Ott, Pascal Gottmann, Thilo Speckmann, Peter Huypens, Stefan Wolter, Oliver Mann, Martin Hrabé De Angelis, Johannes Beckers, Henriette Kirchner, Matthias B. Schulze, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101774- (2023)
Objectives: Better disease management can be achieved with earlier detection through robust, sensitive, and easily accessible biomarkers. The aim of the current study was to identify novel epigenetic biomarkers determining the risk of type 2 diabetes
Externí odkaz:
https://doaj.org/article/cbd304180aef4bbdad8c44ce9af6265c
Autor:
Josephine M. Kanta, Luisa Deisen, Kornelia Johann, Stephanie Holm, Annemarie Lundsgaard, Jens Lund, Markus Jähnert, Annette Schürmann, Christoffer Clemmensen, Bente Kiens, Andreas M. Fritzen, Maximilian Kleinert
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101760- (2023)
Objective: Medium chain fatty acids (MCFAs), which are fatty acids with chain lengths of 8–12 carbon atoms, have been shown to reduce food intake in rodents and humans, but the underlying mechanisms are unknown. Unlike most other fatty acids, MCFAs
Externí odkaz:
https://doaj.org/article/5dd29cdca916406fad79610195385845
Autor:
Sofiya Gancheva, Meriem Ouni, Tomas Jelenik, Chrysi Koliaki, Julia Szendroedi, Frederico G. S. Toledo, Daniel F. Markgraf, Dominik H. Pesta, Lucia Mastrototaro, Elisabetta De Filippo, Christian Herder, Markus Jähnert, Jürgen Weiss, Klaus Strassburger, Matthias Schlensak, Annette Schürmann, Michael Roden
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Externí odkaz:
https://doaj.org/article/f6d5f2f9d8a742059cd874a669fa63d2
Autor:
Leona Kovac, Thilo Speckmann, Markus Jähnert, Pascal Gottmann, Louise Fritsche, Hans-Ulrich Häring, Andreas L. Birkenfeld, Andreas Fritsche, Annette Schürmann, Meriem Ouni
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15673 (2023)
MicroRNAs (miRNAs) recently emerged as means of communication between insulin-sensitive tissues to mediate diabetes development and progression, and as such they present a valuable proxy for epigenetic alterations associated with type 2 diabetes. In
Externí odkaz:
https://doaj.org/article/36e2261c5b244496827683264c63ee65
Autor:
Sarah Voisin, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Sofiya Gancheva, Meriem Ouni, Markus Jähnert, Kevin J. Ashton, Vernon G. Coffey, Jamie‐Lee M. Thompson, Thomas M. Doering, Anne Gabory, Claudine Junien, Robert Caiazzo, Hélène Verkindt, Violetta Raverdy, François Pattou, Philippe Froguel, Jeffrey M. Craig, Sara Blocquiaux, Martine Thomis, Adam P. Sharples, Annette Schürmann, Michael Roden, Steve Horvath, Nir Eynon
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 4, Pp 1064-1078 (2021)
Abstract Background Knowledge of age‐related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large‐scale epigenome‐wide association study meta‐analysis of
Externí odkaz:
https://doaj.org/article/ce55a89fa672408eba78329582af1e29
Autor:
Robert Hauffe, Michaela Rath, Mareike Schell, Katrin Ritter, Kai Kappert, Stefanie Deubel, Christiane Ott, Markus Jähnert, Wenke Jonas, Annette Schürmann, André Kleinridders
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101276- (2021)
Objective: Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. Th
Externí odkaz:
https://doaj.org/article/8e70c968a1694ff39c2a66f6cc5ab0a2
Autor:
Wenke Jonas, Kristin Schwerbel, Lisa Zellner, Markus Jähnert, Pascal Gottmann, Annette Schürmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11863 (2022)
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Various mechanisms such as an increased uptake in fatty acids or de novo synthesis contribute to the development of steatosis and progression to
Externí odkaz:
https://doaj.org/article/3bb9c4df8f3d4349a59e3db16816a505