Zobrazeno 1 - 10
of 467
pro vyhledávání: '"Markus Huber Lang"'
Autor:
Shirin Emtenani, Maike M. Holtsche, Richard Stahlkopf, Daniel L. Seiler, Timothy Burn, Huiqing Liu, Melissa Parker, Kaan Yilmaz, Hasan O. Dikmen, Markus Huber Lang, Christian D. Sadik, Christian M. Karsten, Nina van Beek, Ralf J. Ludwig, Jörg Köhl, Enno Schmidt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Bullous pemphigoid (BP), the by far most frequent autoimmune subepidermal blistering disorder (AIBD), is characterized by the deposition of autoantibodies against BP180 (type XVII collagen; Col17) and BP230 as well as complement components at the der
Externí odkaz:
https://doaj.org/article/e8cb36281fae4c35a6c0ba273e085086
Autor:
Yang Li, Klemens Horst, Johannes Greven, Ümit Mert, Ludmila Lupu, Annette Palmer, Lena Doerfer, Qun Zhao, Xing Zhang, Rebecca Halbgebauer, Anita Ignatius, Ingo Marzi, Martijn van Griensven, Elizabeth Balmayor, Frank Hildebrand, Tom Eirik Mollnes, Markus Huber-Lang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPolytrauma and hemorrhagic shock can lead to direct and indirect liver damage involving intricate pathophysiologic mechanisms. While hepatic function has been frequently highlighted, there is minimal research on how the receptor activator o
Externí odkaz:
https://doaj.org/article/0dd4a07f570e42239e70c8a2eeb84d2e
Autor:
Rida Rehman, Albrecht Froehlich, Florian olde Heuvel, Lobna Elsayed, Tobias Boeckers, Markus Huber-Lang, Cristina Morganti-Kossmann, Francesco Roselli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines. Several receptor tyrosine kinases (RTK) are activated in microgl
Externí odkaz:
https://doaj.org/article/220cf57494bc430bbd6ad738bc33c1d1
Autor:
Rald V. M. Groven, Christel Kuik, Johannes Greven, Ümit Mert, Freek G. Bouwman, Martijn Poeze, Taco J. Blokhuis, Markus Huber-Lang, Frank Hildebrand, Berta Cillero-Pastor, Martijn van Griensven
Publikováno v:
Bone & Joint Research, Vol 13, Iss 5, Pp 214-225 (2024)
Aims: The aim of this study was to determine the fracture haematoma (fxH) proteome after multiple trauma using label-free proteomics, comparing two different fracture treatment strategies. Methods: A porcine multiple trauma model was used in which tw
Externí odkaz:
https://doaj.org/article/573a6f6a87ed43d9be6fe17da2e0373b
Autor:
Julian Roos, Julia Zinngrebe, Markus Huber-Lang, Ludmila Lupu, Miriam A. Schmidt, Hannah Strobel, Mike-Andrew Westhoff, Ulrich Stifel, Florian Gebhard, Martin Wabitsch, Tom Eirik Mollnes, Klaus-Michael Debatin, Rebecca Halbgebauer, Pamela Fischer-Posovszky
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-12 (2024)
Abstract Despite advances in the treatment and care of severe physical injuries, trauma remains one of the main reasons for disability-adjusted life years worldwide. Trauma patients often suffer from disturbances in energy utilization and metabolic d
Externí odkaz:
https://doaj.org/article/9f52a16066934815b7ce2e2190f13169
Autor:
Nan Zhou, Rald V. M. Groven, Klemens Horst, Ümit Mert, Johannes Greven, Tom Eirik Mollnes, Markus Huber-Lang, Martijn van Griensven, Frank Hildebrand, Elizabeth R. Balmayor
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundRespiratory failure can be a severe complication after polytrauma. Extensive systemic inflammation due to surgical interventions, as well as exacerbated post-traumatic immune responses influence the occurrence and progression of respiratory
Externí odkaz:
https://doaj.org/article/7684696c74d540418c2efae014825520
Autor:
Amelie Kuhn, Markus Huber-Lang, Sebastian Weckbach, Jana Riegger, Graciosa Q. Teixeira, Volker Rasche, Jörg Fiedler, Cornelia Neidlinger-Wilke, Rolf E. Brenner
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1692 (2024)
Previous studies indicate an implication of the terminal complement complex (TCC) in disc degeneration (DD). To investigate the functional role of TCC in trauma-induced DD in vivo, the model of endplate (EP) drilling was first applied in rabbits usin
Externí odkaz:
https://doaj.org/article/d75f8a054d524407b6710a36f5300518
Autor:
Arne Maes, Onno Borgel, Clara Braconnier, Tim Balcaen, Martine Wevers, Rebecca Halbgebauer, Markus Huber-Lang, Greet Kerckhofs
Publikováno v:
International Journal of Biomedical Imaging, Vol 2024 (2024)
The kidney’s microstructure, which comprises a highly convoluted tubular and vascular network, can only be partially revealed using classical 2D histology. Considering that the kidney’s microstructure is closely related to its function and is oft
Externí odkaz:
https://doaj.org/article/0a7614c4cb23476d81d858a5dbb0a8ea
Autor:
Bingduo Wang, Aliona Wöhler, Johannes Greven, Rebekka J. S. Salzmann, Cindy M. Keller, Tobias Tertel, Qun Zhao, Ümit Mert, Klemens Horst, Ludmila Lupu, Markus Huber-Lang, Martijn van Griensven, Tom Erik Mollnes, Sebastian Schaaf, Robert Schwab, Christian P. Strassburg, Ingo G. H. Schmidt-Wolf, Bernd Giebel, Frank Hildebrand, Veronika Lukacs-Kornek, Arnulf G. Willms, Miroslaw T. Kornek
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDespite major advances in medicine, blood-borne biomarkers are urgently needed to support decision-making, including polytrauma. Here, we assessed serum-derived extracellular vesicles (EVs) as potential markers of decision-making in polytra
Externí odkaz:
https://doaj.org/article/3b8ca466e5ec44dabab96e095d62f58f
Autor:
Rald Victor Maria Groven, Johannes Greven, Ümit Mert, Klemens Horst, Qun Zhao, Taco Johan Blokhuis, Markus Huber-Lang, Frank Hildebrand, Martijn van Griensven
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTwo trauma treatment principles are Early Total Care (ETC), and Damage Control Orthopedics (DCO). Cellular mechanisms that underlie the connection between treatment type, its systemic effects, and tissue regeneration are not fully known.
Externí odkaz:
https://doaj.org/article/670456bd62f44b06b06b868ff284ae21