Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Markus Hierl"'
Publikováno v:
ACS Omega, Vol 8, Iss 2, Pp 2367-2376 (2023)
Externí odkaz:
https://doaj.org/article/65b2b037476442b1a28ba600e1517857
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2243 (2024)
The monogenetic disease epidermolysis bullosa (EB) is characterised by the formation of extended blisters and lesions on the patient’s skin upon minimal mechanical stress. Causal for this severe condition are genetic mutations in genes, leading to
Externí odkaz:
https://doaj.org/article/50acd7412b184c8c87796fdd23930b46
Autor:
Peter Yakowec, Jin Tang, Violeta Yu, Alexander M. Long, Ralf Schwandner, Tanja Fisch, Josie Han Lee, Renee Emkey, Markus Hierl, Hao Chen
Publikováno v:
SLAS Discovery. 17:27-38
Lysine demethylase 1 (LSD1) and Jumonji C domain-containing oxygenase D2C (JMJD2C) participate in regulating the methylation status of histone H3 lysine residues. In some contexts, LSD1 and JMJD2C activity causes enhanced cellular proliferation, whic
Autor:
Kevin Gaida, Marissa van der Valk, BaoXi Gao, Lei Cao, David J. Matson, Jean-Christophe Harmange, Todd Juan, Katrina W. Copeland, Stephanie Springer, Markus Hierl, Jeff S. McDermott, Dan Waldon, Hong Deng, Brian K. Albrecht, Wenhong Guo, Kristie Clarkin, Hung Q. Nguyen, Johannes Knop, Sonya G. Lehto, Stefan I. McDonough, Alessandro Boezio, Annika B. Malmberg
Publikováno v:
Pain. 149:33-49
Nicotinic acetylcholine receptors (nAChRs) are longstanding targets for a next generation of pain therapeutics, but the nAChR subtypes that govern analgesia remain unknown. We tested a series of nicotinic agonists, including many molecules used or tr
Autor:
Katrina S. Woodin, Brian K. Albrecht, Virginia Berry, Alessandro Boezio, Liyue Huang, Kristie Clarkin, Jean-Christophe Harmange, Hung Q. Nguyen, Markus Hierl, Stephanie Springer, Annika B. Malmberg, Johannes Knop, Stefan I. McDonough, Jeff S. McDermott, Wenhong Guo, Brett Janosky, Daniel Waldon, Lei Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5209-5212
The discovery of a series of small molecule alpha4beta2 nAChR potentiators is reported. The structure-activity relationship leads to potent compounds selective against nAChRs including alpha3beta2 and alpha3beta4 and optimized for CNS penetrance. Com
Autor:
Markus Hierl, Stefan I. McDonough, Stephanie Springer, Jean-Christophe Harmange, Kristie Clarkin, Johannes Knop, Hung Q. Nguyen, Lei Cao, Brian K. Albrecht, Jeff S. McDermott, Annika B. Malmberg, Alessandro Boezio, Virginia Berry, Katrina S. Woodin, Daniel Waldon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5643-5647
The synthesis and structure-activity relationship of a series of carbamate potentiators of alpha4beta2 nAChR is reported herein. These compounds were highly selective for alpha4beta2 over other nAChR subtypes. In addition, compounds increased the res
Autor:
Brett Janosky, April Chen, Elma Feric, John L. Buchanan, Xingwen Li, Peter Miu, Joseph Ligutti, Liyue Huang, Jeff S. McDermott, Markus Hierl, David C. Immke, David J. Matson, Stefan I. McDonough, Annika B. Malmberg, Dong Liu, Anruo Zou, Erin F. DiMauro, Bingfan Du, Xiao Mei Zheng, Hanh Nho Nguyen, Loren Berry, Vinod F. Patel, Daniel Waldon, Ben Wilenkin, Howard Bregman, Danielle Johnson
Publikováno v:
Journal of medicinal chemistry. 54(13)
Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel
Publikováno v:
Free radical biologymedicine. 34(11)
We describe the cloning and expression of two novel genes highly similar to the tocopherol-associated protein (hTAP/SEC14L2/SPF). Immunoprecipitation of the three recombinant hTAPs and extraction of their associated lipid-soluble molecules indicates
Autor:
Bischof, Johannes1 (AUTHOR) j.bischof@salk.at, Hierl, Markus1,2 (AUTHOR) m.hierl@salk.at, Koller, Ulrich1 (AUTHOR) u.koller@salk.at
Publikováno v:
International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2243. 30p.
Autor:
Annika B. Malmberg, Hung Q. Nguyen, Lei Cao, Virginia Berry, Jean-Christophe Harmange, Kristie Clarkin, Jeff S. McDermott, Alessandro Boezio, Johannes Knop, Markus Hierl, Stephanie Springer, Katrina S. Woodin, Daniel Waldon, Brian K. Albrecht, Stefan I. McDonough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4516