Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Markus Hengstschläger"'
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
According to current views the major hallmarks of physiological aging may be subdivided into three categories, primary causes of cellular damage (genomic instability, telomere attrition, loss of proteostasis, epigenetic alterations and compromised ma
Externí odkaz:
https://doaj.org/article/3d415b082fdc490cb074789cab2c3b9e
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Due to the limited accessibility of the in vivo situation, the scarcity of the human tissue, legal constraints, and ethical considerations, the underlying molecular mechanisms of disorders, such as preeclampsia, the pathological consequences
Externí odkaz:
https://doaj.org/article/7b8fd8b2cc27489c99b7943570aa29eb
Autor:
Carlos Bueno‐Beti, Clarice X. Lim, Alexandros Protonotarios, Petra Lujza Szabo, Joseph Westaby, Mario Mazic, Mary N. Sheppard, Elijah Behr, Ouafa Hamza, Attila Kiss, Bruno K. Podesser, Markus Hengstschläger, Thomas Weichhart, Angeliki Asimaki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Sarcoidosis is an inflammatory, granulomatous disease of unknown cause affecting multiple organs, including the heart. Untreated, unresolved granulomatous inflammation can lead to cardiac fibrosis, arrhythmias, and eventually heart failure
Externí odkaz:
https://doaj.org/article/ec6811c75eb84f1c881bd95ef1b7da1c
Autor:
Velina S. Atanasova, Crhistian de Jesus Cardona, Václav Hejret, Andreas Tiefenbacher, Theresia Mair, Loan Tran, Janette Pfneissl, Kristina Draganić, Carina Binder, Julijan Kabiljo, Janik Clement, Katharina Woeran, Barbara Neudert, Sabrina Wohlhaupter, Astrid Haase, Sandra Domazet, Markus Hengstschläger, Markus Mitterhauser, Leonhard Müllauer, Boris Tichý, Michael Bergmann, Gabriele Schweikert, Markus Hartl, Helmut Dolznig, Gerda Egger
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1391-1419 (2023)
Background & Aims: Patient-derived organoid cancer models are generated from epithelial tumor cells and reflect tumor characteristics. However, they lack the complexity of the tumor microenvironment, which is a key driver of tumorigenesis and therapy
Externí odkaz:
https://doaj.org/article/4731d5078fae4db69082355f0d4fbdc9
Autor:
Hans Peter Weitzenböck, Anna Gschwendtner, Christoph Wiesner, Maren Depke, Frank Schmidt, Franz Trautinger, Markus Hengstschläger, Harald Hundsberger, Mario Mikula
Publikováno v:
Cancer Medicine, Vol 11, Iss 4, Pp 956-967 (2022)
Abstract Malignant melanoma is the deadliest form of skin cancer and NRF2 has been proposed as a main regulator of tumor cell malignancy. Still the mechanisms how NRF2 is contributing to melanoma progression are incompletely understood. Here we analy
Externí odkaz:
https://doaj.org/article/6c203d2ccf1f419a834d63c2f9f2095f
Autor:
Clarissa Braun, Karl Katholnig, Christopher Kaltenecker, Monika Linke, Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart
Publikováno v:
Cell Stress, Vol 5, Iss 12, Pp 176-182 (2021)
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin comple
Externí odkaz:
https://doaj.org/article/7ec40a35d4504ab8b854afe0d4185ef4
Autor:
Laurenz Vock, Anna Gschwendtner, Oliver Eckel, Madalina A. Mirea, Markus Hengstschläger, Mario Mikula
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/50e142e6dd4149b18c6eaf62777729fc
Autor:
Velina S. Atanasova, Angelika Riedl, Marcus Strobl, Julia Flandorfer, Daniela Unterleuthner, Claudia Weindorfer, Patrick Neuhold, Simone Stang, Markus Hengstschläger, Michael Bergmann, Helmut Dolznig
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1668 (2023)
Colorectal cancer (CRC) is the second deadliest cancer in the world. Besides APC and p53 alterations, the PI3K/AKT/MTOR and MAPK pathway are most commonly mutated in CRC. So far, no treatment options targeting these pathways are available in routine
Externí odkaz:
https://doaj.org/article/fd17ec69b5fc4e64b081ecb3c1ebb48b
Autor:
Markus Hengstschläger, Margit Rosner
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-3 (2021)
Abstract It is known that in countries, in which basic research on human embryos is in fact prohibited by law, working with imported human embryonic stem cells (hESCs) can still be permitted. As long as hESCs are not capable of development into a com
Externí odkaz:
https://doaj.org/article/c47113793e4c4819b8b5f24f773e1656
Autor:
Claudia Gundacker, Klaudia Graf-Rohrmeister, Martin Gencik, Markus Hengstschläger, Karol Holoman, Petra Rosa, Renate Kroismayr, Ivo Offenthaler, Veronika Plichta, Theresa Reischer, Isabella Teufl, Wolfgang Raffesberg, Sigrid Scharf, Birgit Köhler-Vallant, Zoja Delissen, Stefan Weiß, Maria Uhl
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Prenatal exposure to perfluoroalkyl substances (PFAS), bisphenol A (BPA), lead (Pb), total mercury (THg), and methylmercury (MeHg) can affect fetal development. Factors influencing placental transfer rate of these toxins are poorly investigated. Whet
Externí odkaz:
https://doaj.org/article/4a7b74e122b0411798ae16d1a9d474c7