Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Markus Hecht"'
Autor:
Anna-Jasmina Donaubauer, Benjamin Frey, Manuel Weber, Moritz Allner, Christoph Vogl, Omar Almajali, Lukas Kuczera, Henriette Tamse, Matthias Balk, Sarina Müller, Markus Eckstein, Lilli Zülch, Lia Mogge, Thomas Weissmann, Rainer Fietkau, Marco Kesting, Heinrich Iro, Udo S. Gaipl, Markus Hecht, Antoniu-Oreste Gostian
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The approval and effectiveness of immune checkpoint inhibitors in head-and-neck squamous cell carcinoma (HNSCC) highlights the role of the immune system in this tumor entity. HNSCCs not only interacts with the immune system in the tumor tissue, but a
Externí odkaz:
https://doaj.org/article/1560ba28bb354eafb43295a2a7cc2a27
Autor:
Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective Fast progression (FP) represents a desperate situation for advanced non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor therapy. We aimed to develop a predictive framework based on machine learning (ML) method
Externí odkaz:
https://doaj.org/article/20e430b979254079aac5e5c334ae163c
Autor:
Markus Hecht, Benjamin Frey, Udo S. Gaipl, Xie Tianyu, Markus Eckstein, Anna-Jasmina Donaubauer, Gunther Klautke, Thomas Illmer, Maximilian Fleischmann, Simon Laban, Matthias G. Hautmann, Bálint Tamaskovics, Thomas B. Brunner, Ina Becker, Jian-Guo Zhou, Arndt Hartmann, Rainer Fietkau, Heinrich Iro, Michael Döllinger, Antoniu-Oreste Gostian, Andreas M. Kist
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 49, Iss , Pp 100953- (2024)
Purpose: Individual prediction of treatment response is crucial for personalized treatment in multimodal approaches against head-and-neck squamous cell carcinoma (HNSCC). So far, no reliable predictive parameters for treatment schemes containing immu
Externí odkaz:
https://doaj.org/article/545805f66b504b9d8a9522c916fbe3dc
Autor:
Marion Dörrich, Markus Hecht, Rainer Fietkau, Arndt Hartmann, Heinrich Iro, Antoniu-Oreste Gostian, Markus Eckstein, Andreas M. Kist
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract Purpose Although neural networks have shown remarkable performance in medical image analysis, their translation into clinical practice remains difficult due to their lack of interpretability. An emerging field that addresses this problem is
Externí odkaz:
https://doaj.org/article/5c63d1fe106943e8a343a18f29159cb6
Autor:
Qi Zhao, Jianfeng Li, Xuejun Li, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Peng Luo, Markus Hecht, Udo Gaipl, Shixiang Wang, Yi Xiong, Yihao Zhang, Minjun Chen, Yung-Hung Luo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background Immunotherapies targeting immune checkpoints have gained increasing attention in cancer treatment, emphasizing the need for predictive biomarkers. Circular RNAs (circRNAs) have emerged as critical regulators of tumor immunity, particularly
Externí odkaz:
https://doaj.org/article/c918fd42f1644b83b574fa49efdc8fdc
Autor:
Fridolin Grottker, Simon Gehre, Clara M. Reichardt, Azzaya Sengedorj, Tina Jost, Thorsten Rieckmann, Markus Hecht, Antoniu-Oreste Gostian, Benjamin Frey, Rainer Fietkau, Udo S. Gaipl, Michael Rückert
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 45, Iss , Pp 100944- (2023)
Purpose: Human papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC) tumors respond significantly better to anticancer treatments. It is assumed to be due to a better response to radiotherapy (RT), and presumably to an increase
Externí odkaz:
https://doaj.org/article/3ae950bb462247bab8645708ee22896d
Autor:
Eileen Stoll, Michael Hader, Michael Rückert, Thomas Weissmann, Sebastian Lettmaier, Florian Putz, Markus Hecht, Rainer Fietkau, Andreas Rosin, Benjamin Frey, Udo S. Gaipl
Publikováno v:
International Journal of Hyperthermia, Vol 39, Iss 1, Pp 796-805 (2022)
Purpose Improvements of heat-delivery systems have led to hyperthermia (HT) being increasingly recognized as an adjunct treatment modality also for brain tumors. But how HT affects the immune phenotype of glioblastoma cells is only scarcely known.Mat
Externí odkaz:
https://doaj.org/article/1f897b5885674778b9126cfc438e179d
Autor:
Jian-Guo Zhou, Rui Liang, Hai-Tao Wang, Su-Han Jin, Wei Hu, Benjamin Frey, Rainer Fietkau, Markus Hecht, Hu Ma, Udo S. Gaipl
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 37, Iss , Pp 100877- (2023)
Melanoma is the most aggressive skin malignancy with high morbidity. Anti-programmed cell death protein 1 (PD-1) monotherapy has been applied in metastatic melanoma. However, still most of the patients do not respond to anti-PD-1 and the availability
Externí odkaz:
https://doaj.org/article/826a4327ea4143279dc5a202c61ea90a
Autor:
Moritz Allner, Magdalena Gostian, Matthias Balk, Robin Rupp, Clarissa Allner, Konstantinos Mantsopoulos, Christoph Ostgathe, Heinrich Iro, Markus Hecht, Antoniu-Oreste Gostian
Publikováno v:
BMC Palliative Care, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background Advance Care Planning including living wills and durable powers of attorney for healthcare is a highly relevant topic aiming to increase patient autonomy and reduce medical overtreatment. Data from patients with head and neck canc
Externí odkaz:
https://doaj.org/article/5ca130501e7747299220dafe76d0032f
Publikováno v:
Cells, Vol 12, Iss 20, p 2427 (2023)
Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness. Following high-LET IR, localized energy deposition along the particle trajector
Externí odkaz:
https://doaj.org/article/7028ccd34ec14529ac8410ef8b0e6441