Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Markus HIldenbeutel"'
Autor:
Benjamin C. Houghton, Neelam Panchal, Simone A. Haas, Kay O. Chmielewski, Markus Hildenbeutel, Thomas Whittaker, Claudio Mussolino, Toni Cathomen, Adrian J Thrasher, Claire Booth
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the SH2D1A gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for mediating several key immu
Externí odkaz:
https://doaj.org/article/e1802e6cee45487398ad67ff6d224f5a
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Externí odkaz:
https://doaj.org/article/e8aa757ae0ec4109904f3108d8338f68
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 379-388 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Autor:
Benjamin C. Houghton, Neelam Panchal, Simone A. Haas, Kay O. Chmielewski, Markus Hildenbeutel, Thomas Whittaker, Claudio Mussolino, Toni Cathomen, Adrian J Thrasher, Claire Booth
Publikováno v:
Frontiers in genome editing. 4
X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the SH2D1A gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for mediating several key immu
Autor:
Marianna Romito, Alexandre Juillerat, Yik Lim Kok, Markus HIldenbeutel, Manuel Rhiel, Geoffroy Andrieux, Johannes Geiger, Carsten Rudolph, Claudio Mussolino, Aymeric Duclert, Karin Metzner, Philippe Duchateau, Toni Cathomen, Tatjana Cornu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8be911dec1765bbbd32add1d649420e
https://doi.org/10.22541/au.158990011.12602649
https://doi.org/10.22541/au.158990011.12602649
Autor:
Philippe Duchateau, Claudio Mussolino, Johannes Geiger, Aymeric Duclert, Markus Hildenbeutel, Alexandre Juillerat, Geoffroy Andrieux, Tatjana I. Cornu, Carsten Rudolph, Marianna Romito, Yik Lim Kok, Manuel Rhiel, Toni Cathomen, Karin J. Metzner
Publikováno v:
Biotechnology journal. 16(1)
Therapies to treat patients infected with human immunodeficiency virus (HIV) aim at preventing viral replication but fail to eliminate the virus. Although transplantation of allogeneic CCR5Δ32 homozygous stem cell grafts provided a cure for a few pa
Autor:
Sandra Nitsch, Claudio Mussolino, Markus Hildenbeutel, Claudia Bossen, Toni Cathomen, Tafadzwa Mlambo, Tatjana I. Cornu, Marianna Romito, Maximilian Müller, Sven Diederichs
Publikováno v:
Nucleic Acids Research
Targeted modulation of gene expression represents a valuable approach to understand the mechanisms governing gene regulation. In a therapeutic context, it can be exploited to selectively modify the aberrant expression of a disease-causing gene or to
Publikováno v:
BIOspektrum. 23:155-158
Programmable nucleases, such as zinc finger nucleases, TALE nucleases, and CRISPR-Cas nucleases, allow for the introduction of precise modifications in the human genome. As a consequence, targeted genome editing has heralded a new area for gene thera
Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation
Autor:
Brigitte Meunier, Katharina Stephan, Steffi Gruschke, Eric L. Hegg, Markus Hildenbeutel, Martin Ott
Publikováno v:
The Journal of Cell Biology
Assembly of the two heme b cofactors into the respiratory chain complex III subunit cytochrome b occurs in a step-by-step process that is monitored by assembly factors and regulates additional cytochrome b synthesis through a feedback loop.
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Autor:
Claudio Mussolino, Helena Heinz, Sushmita Poddar, Giandomenico Turchiano, Brian W. Busser, Markus Hildenbeutel, Marianna Romito, Tatjana I. Cornu, Anne-Sophie Gautron, Yik Lim Kok, Toni Cathomen, Julianne Smith, Simone A. Haas, Julia Rositzka, Emily Meyer, Richard Schäfer, Karin J. Metzner, Philippe Duchateau
Publikováno v:
Web of Science
Targeted genome editing in blood and immune cells enable new therapeutic applications, especially for infectious diseases. We present a GMP-compliant protocol to manufacture CCR5-edited CD34+ hematopoietic stem and precursor cells (HSPCs) with the go