Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Markus H Heim"'
Autor:
Polina Suter, Eva Dazert, Jack Kuipers, Charlotte K Y Ng, Tuyana Boldanova, Michael N Hall, Markus H Heim, Niko Beerenwinkel
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1009767 (2022)
Comprehensive molecular characterization of cancer subtypes is essential for predicting clinical outcomes and searching for personalized treatments. We present bnClustOmics, a statistical model and computational tool for multi-omics unsupervised clus
Externí odkaz:
https://doaj.org/article/00fabc0f584743428d737f10c282a558
Autor:
Huong T L Tran, Kenichi Morikawa, Anggakusuma, Rose Zibi, Viet Loan Dao Thi, François Penin, Markus H Heim, Manfredo Quadroni, Thomas Pietschmann, Jérôme Gouttenoire, Darius Moradpour
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236447 (2020)
The hepatitis C virus (HCV) nonstructural protein 3-4A (NS3-4A) protease is a key component of the viral replication complex and the target of protease inhibitors used in current clinical practice. By cleaving and thereby inactivating selected host f
Externí odkaz:
https://doaj.org/article/92585b5b50cd407a937b9f53b4654bb5
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 6, Pp 816-834 (2017)
Abstract Hepatitis C virus (HCV) is widely used to investigate host–virus interactions. Cellular responses to HCV infection have been extensively studied in vitro. However, in human liver, interferon (IFN)‐stimulated gene expression can mask dire
Externí odkaz:
https://doaj.org/article/5a80467447f84b36969c596a8f86a7fd
Autor:
Diego Calabrese, Guglielmo Roma, Sebastian Bergling, Walter Carbone, Valentina Mele, Sandro Nuciforo, Isabel Fofana, Benedetta Campana, Dagmara Szkolnicka, David C Hay, Jan Tchorz, Tewis Bouwmeester, Stefan Wieland, Markus H Heim
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221762 (2019)
Background & aimsHepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iPSCs) have emerged as a promising cell culture model to study metabolism, biotransformation, viral infections and inherited liver diseases. iPSCs provi
Externí odkaz:
https://doaj.org/article/eab6c893049b48f6b2729aa696405960
Autor:
Christine Bernsmeier, Diego M Weisskopf, Marlon O Pflueger, Jan Mosimann, Benedetta Campana, Luigi Terracciano, Christoph Beglinger, Markus H Heim, Christian Cajochen
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143293 (2015)
Sleep disturbance is associated with the development of obesity, diabetes and hepatic steatosis in murine models. Hepatic triglyceride accumulation oscillates in a circadian rhythm regulated by clock genes, light-dark cycle and feeding time in mice.
Externí odkaz:
https://doaj.org/article/109c9ebf63b541939400102fc8c922b8
Autor:
Clive J Hoggart, Giulia Venturini, Massimo Mangino, Felicia Gomez, Giulia Ascari, Jing Hua Zhao, Alexander Teumer, Thomas W Winkler, Natalia Tšernikova, Jian'an Luan, Evelin Mihailov, Georg B Ehret, Weihua Zhang, David Lamparter, Tõnu Esko, Aurelien Macé, Sina Rüeger, Pierre-Yves Bochud, Matteo Barcella, Yves Dauvilliers, Beben Benyamin, David M Evans, Caroline Hayward, Mary F Lopez, Lude Franke, Alessia Russo, Iris M Heid, Erika Salvi, Sailaja Vendantam, Dan E Arking, Eric Boerwinkle, John C Chambers, Giovanni Fiorito, Harald Grallert, Simonetta Guarrera, Georg Homuth, Jennifer E Huffman, David Porteous, Generation Scotland Consortium, LifeLines Cohort study, GIANT Consortium, Darius Moradpour, Alex Iranzo, Johannes Hebebrand, John P Kemp, Gert J Lammers, Vincent Aubert, Markus H Heim, Nicholas G Martin, Grant W Montgomery, Rosa Peraita-Adrados, Joan Santamaria, Francesco Negro, Carsten O Schmidt, Robert A Scott, Tim D Spector, Konstantin Strauch, Henry Völzke, Nicholas J Wareham, Wei Yuan, Jordana T Bell, Aravinda Chakravarti, Jaspal S Kooner, Annette Peters, Giuseppe Matullo, Henri Wallaschofski, John B Whitfield, Fred Paccaud, Peter Vollenweider, Sven Bergmann, Jacques S Beckmann, Mehdi Tafti, Nicholas D Hastie, Daniele Cusi, Murielle Bochud, Timothy M Frayling, Andres Metspalu, Marjo-Riitta Jarvelin, André Scherag, George Davey Smith, Ingrid B Borecki, Valentin Rousson, Joel N Hirschhorn, Carlo Rivolta, Ruth J F Loos, Zoltán Kutalik
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004508 (2014)
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits in
Externí odkaz:
https://doaj.org/article/6b5ebe329cc640c482a2dc731b70d7f4
Autor:
Christine Bernsmeier, Anne C Meyer-Gerspach, Lea S Blaser, Lia Jeker, Robert E Steinert, Markus H Heim, Christoph Beglinger
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87488 (2014)
The incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are gastrointestinal peptide hormones regulating postprandial insulin release from pancreatic β-cells. GLP-1 agonism is a treatment strategy in Type
Externí odkaz:
https://doaj.org/article/1cbbb0e34ee14a52a39df29061d70013
Autor:
Christian M Lange, Daiki Miki, Hidenori Ochi, Hans-Dieter Nischalke, Jörg Bojunga, Stéphanie Bibert, Kenichi Morikawa, Jérôme Gouttenoire, Andreas Cerny, Jean-François Dufour, Meri Gorgievski-Hrisoho, Markus H Heim, Raffaele Malinverni, Beat Müllhaupt, Francesco Negro, David Semela, Zoltan Kutalik, Tobias Müller, Ulrich Spengler, Thomas Berg, Kazuaki Chayama, Darius Moradpour, Pierre-Yves Bochud, Hiroshima Liver Study Group, Swiss Hepatitis C Cohort Study Group
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64053 (2013)
Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk
Externí odkaz:
https://doaj.org/article/e963bbb7a51b4bcb81c9113e0b0e6429
Autor:
Lorenz Kuske, Armand Mensen, Beat Müllhaupt, Francesco Negro, David Semela, Darius Moradpour, Pierre Jean Malé, Markus H Heim, Raffaele Malinverni, Andreas Cerny, Jean-Francois Dufour
Publikováno v:
Swiss Medical Weekly, Vol 142, Iss 3132 (2012)
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is the most frequent form of primary liver cancer and chronic infection with hepatitis C virus is one of the main risk factors for HCC. This study analyses the characteristics of the patients with ch
Externí odkaz:
https://doaj.org/article/0c90c0d537934fba9b052d581aa6c2d9
Autor:
Christian M Lange, Stephanie Bibert, Zoltan Kutalik, Philippe Burgisser, Andreas Cerny, Jean-Francois Dufour, Andreas Geier, Tilman J Gerlach, Markus H Heim, Raffaele Malinverni, Francesco Negro, Stephan Regenass, Klaus Badenhoop, Jörg Bojunga, Christoph Sarrazin, Stefan Zeuzem, Tobias Müller, Thomas Berg, Pierre-Yves Bochud, Darius Moradpour, Swiss Hepatitis C Cohort Study Group
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40159 (2012)
BACKGROUND:To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. METHODOLOGY/PRINCIPAL FINDINGS:Associations between a functionally relevant polymorph
Externí odkaz:
https://doaj.org/article/6c54a69ff3b44210aa78d7d2749f4188