Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Markus H Gräler"'
Autor:
Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-17 (2021)
Abstract Jaundice, the clinical hallmark of infection‐associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3‐kinase‐γ (PI3Kγ) are
Externí odkaz:
https://doaj.org/article/0fad10ab812d436c8a511f93c2eb66d8
Autor:
Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler, Ralf A Claus
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 412-423 (2016)
Abstract The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biological effects in endothelial stre
Externí odkaz:
https://doaj.org/article/334c1b6047c34ed2ada0a927a7365093
Autor:
Isabelle Seidita, Anke Ziegler, Auron Qalaj, Martin Sebastian Winkler, Axel Nierhaus, Stefan Kluge, Bodo Levkau, Markus H. Gräler
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111168- (2024)
Summary: Flow-induced dispersion analysis (FIDA) was used to investigate the association of fluorescein isothiocyanate-labeled signaling lipid sphingosine 1-phosphate (S1P) with its carrier molecules human serum albumin (HSA) and high-density lipopro
Externí odkaz:
https://doaj.org/article/c041be22ce3940f9adbd4637fb0dbfa2
Autor:
Christian von Loeffelholz, René Winkler, Cynthia Weigel, Eva-Maria Piskor, Wolfgang Vivas, Falk Rauchfuß, Utz Settmacher, Ignacio Rubio, Sebastian Weis, Markus H. Gräler, Michael Bauer, Christian Kosan
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110133- (2024)
Summary: Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Myeloid cell accumulation and lymphocyte decline are widely recognized phenomena in septic patients. However, the fate of specific immune cells remain
Externí odkaz:
https://doaj.org/article/dff136deb42c4878b3c89f7959d4579e
Autor:
Nadine Thomas, Nathalie H. Schröder, Melissa K. Nowak, Philipp Wollnitzke, Shahrooz Ghaderi, Karin von Wnuck Lipinski, Annalena Wille, Jennifer Deister-Jonas, Jens Vogt, Markus H. Gräler, Lisa Dannenberg, Tobias Buschmann, Philipp Westhoff, Amin Polzin, Malte Kelm, Petra Keul, Sarah Weske, Bodo Levkau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Red blood cells (RBC) are the major carriers of sphingosine-1-phosphate (S1P) in blood. Here we show that variations in RBC S1P content achieved by altering S1P synthesis and transport by genetic and pharmacological means regulate glucose up
Externí odkaz:
https://doaj.org/article/e7bc77bce542466b84c00d135951cee7
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116575- (2024)
Sepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host response to an infection. Despite numerous clinical trials that addressed this syndrome, there is still no causative treatment available to dampen its severit
Externí odkaz:
https://doaj.org/article/010e0b30ea494d14a19a8f95cf48134c
Autor:
Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Carolin Helten, Philipp Mourikis, Samantha Ahlbrecht, Laura Wildeis, Justus Ziese, Dorothee Zikeli, Daniel Metzen, Hao Hu, Leonard Baensch, Nathalie H. Schröder, Petra Keul, Sarah Weske, Philipp Wollnitzke, Dragos Duse, Süreyya Saffak, Mareike Cramer, Florian Bönner, Tina Müller, Markus H. Gräler, Tobias Zeus, Malte Kelm, Bodo Levkau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Antiplatelet medication is standard of care in acute myocardial infarction (AMI). However, it may have obscured beneficial properties of the activated platelet secretome. We identify platelets as major source of a sphingosine-1-phosphate (S1
Externí odkaz:
https://doaj.org/article/69086935381d4c428839f590beca54d4
Autor:
Giorgio Caratti, Ulrich Stifel, Bozhena Caratti, Ali J. M. Jamil, Kyoung-Jin Chung, Michael Kiehntopf, Markus H. Gräler, Matthias Blüher, Alexander Rauch, Jan P. Tuckermann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven inflammation of adipose tissue. Whether anti-inflammatory glucocorticoids (GCs) at physiological levels modulate IR is unclear. Here, we report that d
Externí odkaz:
https://doaj.org/article/d8ef65c7f37a4329a032780b81c13c16
Autor:
Annika Döding, Svenja Zimmermann, Ahmed Maghames, Michael Reimann, Judit Symmank, Maria Thürmer, Markus H. Gräler, Michael Wolf, Collin Jacobs, Andreas Koeberle, Bernd Sigusch, Ulrike Schulze-Späte
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionNovel preventive strategies in periodontal disease target the bacterial-induced inflammatory host response to reduce associated tissue destruction. Strategies focus on the modulation of tissue-destroying inflammatory host response, partic
Externí odkaz:
https://doaj.org/article/eb5f2975c85c47b6b9ec4a4daa21bbd9
Autor:
Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau
Publikováno v:
ESC Heart Failure, Vol 10, Iss 1, Pp 334-341 (2023)
Abstract Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury. However, its impact on post‐ischaemic remodelling indepe
Externí odkaz:
https://doaj.org/article/ff12a4b41a044c2dbe150ec1060b1b94