Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Markus G Manz"'
A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Frauke Seehusen, Abdullah Elsayed, Emanuele Puca, Roberto De Luca, Christian Pellegrino, Thomas Look, Tobias Weiss, Markus G Manz, Cornelia Halin, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 904-926 (2024)
Abstract Cytokine-based therapeutics have been shown to mediate objective responses in certain tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents dose escalation to therapeutically active regimens. The a
Externí odkaz:
https://doaj.org/article/3f9295ee87c944c5ae3975d61e53a157
Autor:
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre PA Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus G Manz, Steffen Boettcher
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 445-474 (2024)
Abstract TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option f
Externí odkaz:
https://doaj.org/article/3995291a6c424aeaadea031a81b64f56
Autor:
Hind Hashwah, Katrin Bertram, Kristin Stirm, Anna Stelling, Cheuk‐Ting Wu, Sabrina Kasser, Markus G Manz, Alexandre P Theocharides, Alexandar Tzankov, Anne Müller
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Interleukin‐6 (IL‐6) is a growth factor for normal B cells and plasma cell‐derived malignancies. Here, we show that the IL‐6 signaling pathway is also active in a subset of diffuse large B‐cell lymphoma (DLBCL) patients with partic
Externí odkaz:
https://doaj.org/article/33d8140658414823b96db1c8542160aa
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005803 (2017)
Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating betw
Externí odkaz:
https://doaj.org/article/01a9715644404a66a9ac4ffa025b1a82
Autor:
Stephan Wueest, Rouven Mueller, Matthias Blüher, Flurin Item, Annie S H Chin, Michael S F Wiedemann, Hitoshi Takizawa, Larisa Kovtonyuk, Alexander V Chervonsky, Eugen J Schoenle, Markus G Manz, Daniel Konrad
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 1, Pp 43-56 (2013)
Abstract Low‐grade inflammation in adipose tissue and liver has been implicated in obesity‐associated insulin resistance and type 2 diabetes. Yet, the contribution of inflammatory cells to the pathogenesis of skeletal muscle insulin resistance re
Externí odkaz:
https://doaj.org/article/9d74136612fe48bbb5632bb36b008aa8
Autor:
Ilona Hauber, Helga Hofmann-Sieber, Jan Chemnitz, Danilo Dubrau, Janet Chusainow, Rolf Stucka, Philip Hartjen, Axel Schambach, Patrick Ziegler, Karl Hackmann, Evelin Schröck, Udo Schumacher, Christoph Lindner, Adam Grundhoff, Christopher Baum, Markus G Manz, Frank Buchholz, Joachim Hauber
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003587 (2013)
Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. Howeve
Externí odkaz:
https://doaj.org/article/a30385a2f1f846a49457496bcee83427
Autor:
Julien Villaudy, Mélanie Wencker, Nicolas Gadot, Nicolas A Gillet, Jean-Yves Scoazec, Louis Gazzolo, Markus G Manz, Charles R M Bangham, Madeleine Duc Dodon
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002231 (2011)
Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ß-selection, an important checkpoint of early thymopoiesi
Externí odkaz:
https://doaj.org/article/5e8c6cb1e1de46aaad1f100085d5aa86
Autor:
Francisco Caiado, Larisa V. Kovtonyuk, Nagihan G. Gonullu, Jonas Fullin, Steffen Boettcher, Markus G. Manz
Publikováno v:
Blood. 141:886-903
Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature hematopoietic cells in ≥4% of blood leukocytes. CHIP associates with adv
Autor:
Tim Grob, Mathijs A. Sanders, Christian M. Vonk, Franҫois G. Kavelaars, Melissa Rijken, Diana W. Hanekamp, Patrycja L. Gradowska, Jacqueline Cloos, Yngvar Fløisand, Marinus van Marwijk Kooy, Markus G. Manz, Gert J. Ossenkoppele, Lidwine W. Tick, Violaine Havelange, Bob Löwenberg, Mojca Jongen-Lavrencic, Peter J.M. Valk
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(4):JCO2200715, 756-765. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(4), 756-765. American Society of Clinical Oncology
Grob, T, Sanders, M A, Vonk, C M, Kavelaars, F G, Rijken, M, Hanekamp, D W, Gradowska, P L, Cloos, J, Fløisand, Y, van Marwijk Kooy, M, Manz, M G, Ossenkoppele, G J, Tick, L W, Havelange, V, Löwenberg, B, Jongen-Lavrencic, M & Valk, P J M 2023, ' Prognostic Value of FLT3-Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 41, no. 4, pp. 756-765 . https://doi.org/10.1200/JCO.22.00715, https://doi.org/10.1200/JCO.22.00715
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(4), 756-765. American Society of Clinical Oncology
Grob, T, Sanders, M A, Vonk, C M, Kavelaars, F G, Rijken, M, Hanekamp, D W, Gradowska, P L, Cloos, J, Fløisand, Y, van Marwijk Kooy, M, Manz, M G, Ossenkoppele, G J, Tick, L W, Havelange, V, Löwenberg, B, Jongen-Lavrencic, M & Valk, P J M 2023, ' Prognostic Value of FLT3-Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 41, no. 4, pp. 756-765 . https://doi.org/10.1200/JCO.22.00715, https://doi.org/10.1200/JCO.22.00715
PURPOSE The applicability of FLT3-internal tandem duplications ( FLT3-ITD) for assessing measurable residual disease (MRD) in acute myeloid leukemia (AML) in complete remission (CR) has been hampered by patient-specific duplications and potential ins
Autor:
Sara Puglioli, Eleonore Schmidt, Christian Pellegrino, Luca Prati, Sebastian Oehler, Roberto De Luca, Andrea Galbiati, Claudia Comacchio, Lisa Nadal, Jörg Scheuermann, Markus G. Manz, Dario Neri, Samuele Cazzamalli, Gabriele Bassi, Nicholas Favalli
Publikováno v:
Chem. 9:411-429