Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Markus G Gebauer"'
Publikováno v:
European Journal of Medicinal Chemistry. 38:719-728
In a program to design and develop mechanism-based compounds active as substrates and inhibitors of dihydrofolate reductase (DHFR), we report the synthesis and physical properties of the 6-methyl- (7), 8-methyl- (8a), and 8-ethyl- (8b) derivatives of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a035ee4b7ccd1f6aad28a8559fa6e14a
https://doi.org/10.1016/s0223-5234(03)00140-5
https://doi.org/10.1016/s0223-5234(03)00140-5
Publikováno v:
Biomedical Chromatography. 16:241-246
Zopiclone is a hypnosedative with clinical effects similar to benzodiazepines but thought to have less potential for rebound insomnia and withdrawal effects. Zopiclone is administered as a racemic mixture, and an enantiospecific method of analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88167b86328a0e83c6f0c545884f2855
https://doi.org/10.1002/bmc.135
https://doi.org/10.1002/bmc.135
Publikováno v:
International Journal of Pharmaceutics. 223:49-54
An HPLC method for the quantification of oxycodone and lidocaine in a gel matrix is described. The mobile phase consisted of methanol--water--acetic acid (35:15:1 v/v/v) and was delivered at 1.5 ml/min through a 4.6 x 250 mm Zorbax SB-C8 column. Oxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c3f46e7eceb1177f7ff5a06c84ad2
https://doi.org/10.1016/s0378-5173(01)00729-3
https://doi.org/10.1016/s0378-5173(01)00729-3
Autor:
Markus G. Gebauer, Geoffrey T. Crisp
Publikováno v:
Journal of Organometallic Chemistry. 532:83-88
The hydrostannation of methyl ( R,S )-2-( N -diphenylmethylidene) aminopent-4-ynoate induced by a wide variety of transition metal complexes has been studied. The resulting isomeric α-amino acid derivatives featured a tributylvinylstannane in the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a0884a728c108b1bb610f7a4475db7f
https://doi.org/10.1016/s0022-328x(96)06752-6
https://doi.org/10.1016/s0022-328x(96)06752-6
Autor:
Markus G. Gebauer, Geoffrey T. Crisp
Publikováno v:
Tetrahedron. 52:12465-12474
The Heck couplings of protected 2-aminobut-3-en-1-ols with cyclohexenyl triflate can be readily carried out using a “ligand-free” palladium catalyst, potassium carbonate and tetrabutylammonium triflate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4971ddc7f2e1fedbf4fbfd39d378506
https://doi.org/10.1016/0040-4020(96)00714-4
https://doi.org/10.1016/0040-4020(96)00714-4
Autor:
Markus G. Gebauer, Geoffrey T. Crisp
Publikováno v:
The Journal of Organic Chemistry. 61:8425-8431
Structurally related 1,3-dienes 3a−f attached to a chiral carbon were treated with maleic anhydride under a variety of conditions. The initial Diels−Alder adducts were not isolated as they spontaneously rearranged to the isomeric isoindolones 6 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7793b0ab5508153f1b1fdbeae2370aa
https://doi.org/10.1021/jo9609743
https://doi.org/10.1021/jo9609743
Autor:
Geoffrey T. Crisp, Markus G. Gebauer
Publikováno v:
Tetrahedron Letters. 36:3389-3392
The relative reactivities of vinylstannanes 2a,b and 4a,b in a Stille coupling with vinyl bromide were studied under a variety of conditions. Vinyl bromide coupled with the sterically hindered vinylstannane 2a preferentially compared to the less hind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1dfdfb7f8befca9bd32aee8f227985
https://doi.org/10.1016/0040-4039(95)00489-y
https://doi.org/10.1016/0040-4039(95)00489-y
Autor:
Markus G. Gebauer, Geoffrey T. Crisp
Publikováno v:
ChemInform. 28
The Heck couplings of protected 2-aminobut-3-en-1-ols with cyclohexenyl triflate can be readily carried out using a “ligand-free” palladium catalyst, potassium carbonate and tetrabutylammonium triflate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9d3f27c5f1e31e1009c57cf3d3ba418
https://doi.org/10.1002/chin.199703112
https://doi.org/10.1002/chin.199703112
Autor:
Markus G. Gebauer, Geoffrey T. Crisp
Publikováno v:
ChemInform. 28
Structurally related 1,3-dienes 3a−f attached to a chiral carbon were treated with maleic anhydride under a variety of conditions. The initial Diels−Alder adducts were not isolated as they spontaneously rearranged to the isomeric isoindolones 6 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc964892bb3483783d80033b5827ac5
https://doi.org/10.1002/chin.199717100
https://doi.org/10.1002/chin.199717100
Autor:
Markus G Gebauer
Publikováno v:
Bioorganicmedicinal chemistry. 15(6)
4-Hydroxycoumarins such as warfarin 1 have been the mainstay of oral anticoagulation therapy for over 20 years. Yet little detail is known about the molecular interactions between 4-hydroxycoumarins with vitamin K epoxide reductase (VKER), inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c9e7c2e7e6efabfbb422a565d0574
https://pubmed.ncbi.nlm.nih.gov/17275317
https://pubmed.ncbi.nlm.nih.gov/17275317