Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Markus Gütlich"'
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP11Edited by I. Wilson
Autor:
Gerd Bader, Anja Herrmann, Susanne Schiffmann, Markus Gütlich, Adelbert Bacher, Tarmo Ploom, Thorsten Lemm, Günter Auerbach, Markus Fischer, Robert Huber
Publikováno v:
Journal of Molecular Biology. 312:1051-1057
Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c26ae39f0b0806e4a2c6751c942fc127
https://doi.org/10.1006/jmbi.2001.5011
https://doi.org/10.1006/jmbi.2001.5011
Autor:
Andreas Bracher, Nicholas Schramek, Harald Ritz, Eva Götze, Adelbert Bacher, Markus Gütlich, Anja Herrmann, Wolfgang Eisenreich
Publikováno v:
Journal of Biological Chemistry. 273:28132-28141
GTP cyclohydrolase I catalyzes a ring expansion affording dihydroneopterin triphosphate from GTP. [1',2',3',4',5'-13C5, 2'-2H1]GTP was prepared enzymatically from [U-13C6]glucose for use as enzyme substrate. Multinuclear NMR experiments showed that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d54b52586cdfc4f7b86d9aeb40a0106a
https://doi.org/10.1074/jbc.273.43.28132
https://doi.org/10.1074/jbc.273.43.28132
Autor:
Wolfgang Rödl, Irmgard Ziegler, Adelbert Bacher, Markus Gütlich, Klaus Witter, Thomas Werner, Dolores J. Cahill
Publikováno v:
Biochemical Journal. 319:27-32
The GTP cyclohydrolase I (GTP-CH) gene of the cellular slime mould Dictyostelium discoideum has been cloned and sequenced. The 855 bp cDNA of this gene contains the open reading frame (ORF) encoding 232 amino acids with a predicted molecular mass of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb1be098d10c41ae51d3f13ab5bc85b
https://doi.org/10.1042/bj3190027
https://doi.org/10.1042/bj3190027
Publikováno v:
Biochemical Journal. 314:95-101
6-(D-threo-1´,2´-Dihydroxypropylpterin (dictyopterin) has been identified in extracts of growing Dictyostelium discoideum cells [Klein, Thiery and Tatischeff (1990) Eur. J. Biochem. 187, 665–669]. We demonstrate that it originates from GTP by de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e2e3fa5f8ea214a912a4b65708062
https://doi.org/10.1042/bj3140095
https://doi.org/10.1042/bj3140095
Publikováno v:
Biochemical and Biophysical Research Communications. 218:273-279
GTP-cyclohydrolase I is the first enzyme in the biosynthetic pathway leading to folic acid and tetrahydrobiopterin. We determined the complete sequence of the GTP-cyclohydrolase I gene from the yeast Saccharomyces cerevisiae. The gene, which is locat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dd2a8aecdb73868b375909dda3d733
https://doi.org/10.1006/bbrc.1996.0048
https://doi.org/10.1006/bbrc.1996.0048
Autor:
Irmgard Ziegler, Wolfgang Rödl, Klaus Witter, Gerd Katzenmeier, Thomas Wernert, Markus Gütlich, Adelbert Bacher
Publikováno v:
Pteridines, Vol 6, Iss 3, Pp 108-111 (1995)
Summary We have isolated genomic clones that contained the gene for human GTP cyclohydrolase I. One clone containing the 5'-regulatory region of this gene was further analysed. It encompassed the first exon, parts of the first intron and about 2.6kb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475429fd8d17d58b386f5c332ed86ffa
https://doaj.org/article/4cb01306249447c0bfe59b15169597d5
https://doaj.org/article/4cb01306249447c0bfe59b15169597d5
Publikováno v:
Chemistrybiology. 20(1)
SummaryLipid translocation from one lipid bilayer leaflet to the other, termed flip-flop, is required for the distribution of newly synthesized phospholipids during membrane biogenesis. However, a dedicated biogenic lipid flippase has not yet been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b051259ca1d65b981fc7f7c8ef3a21
https://pubmed.ncbi.nlm.nih.gov/23352140
https://pubmed.ncbi.nlm.nih.gov/23352140
Publikováno v:
Journal of Cellular Physiology. 156:12-16
The development of tetrahydrobiopterin synthesis during lectin stimulation of resting human T lymphocytes (Kerler et al. [1989] FEBS Lett., 250:622–624), the interferon-γ induced neopterin production by human monocytes/macrophages (Huber et al. [1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139b917463696081276d325f4fb585da
https://doi.org/10.1002/jcp.1041560103
https://doi.org/10.1002/jcp.1041560103
Publikováno v:
BMC Biochemistry
BMC biochemistry, 6:24
BMC Biochemistry, Vol 6, Iss 1, p 24 (2005)
BMC biochemistry, 6:24
BMC Biochemistry, Vol 6, Iss 1, p 24 (2005)
Background Insect cells can serve as host systems for the recombinant expression of eukaryotic proteins. Using this platform, the controlled expression of 15N/13C labelled proteins requires the analysis of incorporation paths and rates of isotope-lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fd5a86d480a6e07bfa65054aee9ea9
https://pubmed.ncbi.nlm.nih.gov/16285881
https://pubmed.ncbi.nlm.nih.gov/16285881
Autor:
Günter Auerbach, Gerd Bader, Robert Huber, Nicholas Schramek, Markus Fischer, Adelbert Bacher, Andreas Bracher, Markus Gütlich, Wolfgang Eisenreich
Publikováno v:
Chemistry and Biology of Pteridines and Folates ISBN: 9781461353171
GTP cyclohydrolase I catalyzes a ring expansion affording dihydroneopterin triphosphate from GTP (1, 2). The reaction involves the release of C-8 of GTP as formate. The catalytic domain of the human enzyme shows 37% identity with that of Escherichia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd97cbe0bfe1861b19cae86d675e78dd
https://doi.org/10.1007/978-1-4615-0945-5_28
https://doi.org/10.1007/978-1-4615-0945-5_28
