Zobrazeno 1 - 10
of 7 473
pro vyhledávání: '"Markus G"'
Autor:
Rebekka Wegmann, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Ricardo Coelho, Cinzia Esposito, Joanna Ficek-Pascual, Sandra Goetze, Gabriele Gut, Francis Jacob, Andrea Jacobs, Jack Kuipers, Ulrike Lischetti, Julien Mena, Emanuela S. Milani, Michael Prummer, Jacobo Sarabia Del Castillo, Franziska Singer, Sujana Sivapatham, Nora C. Toussaint, Oliver Vilinovszki, Mattheus H. E. Wildschut, Tharshika Thavayogarajah, Disha Malani, The TumorProfiler Consortium, Rudolf Aebersold, Marina Bacac, Niko Beerenwinkel, Christian Beisel, Bernd Bodenmiller, Viola Heinzelmann-Schwarz, Viktor H. Koelzer, Mitchell P. Levesque, Holger Moch, Lucas Pelkmans, Gunnar Rätsch, Markus Tolnay, Andreas Wicki, Bernd Wollscheid, Markus G. Manz, Berend Snijder, Alexandre P. A. Theocharides
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) wit
Externí odkaz:
https://doaj.org/article/d909919fc46044dd87b6ffb2a1e8a194
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The understanding of recent climate extremes and the characterization of climate risk require examining these extremes within a historical context. However, the existing datasets of observed extremes generally exhibit spatial gaps and inaccu
Externí odkaz:
https://doaj.org/article/bdd8786ef2d4422396dcd9dd24ad6cd7
Autor:
Christian Pellegrino, Nicholas Favalli, Laura Volta, Ramon Benz, Sara Puglioli, Gabriele Bassi, Kathrin Zitzmann, Christoph Josef Auernhammer, Svenja Nölting, Chiara F. Magnani, Dario Neri, Felix Beuschlein, Markus G. Manz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Somatostatin receptor type 2 (SSTR2) is one of the five subtypes of somatostatin receptors and is overexpressed on the surface of most gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), pituitary tumors, paraganglioma, and meningioma, as well
Externí odkaz:
https://doaj.org/article/3ef1e2ed9ab14eb1a9a52aba835a4e4d
Autor:
Laura Volta, Renier Myburgh, Mara Hofstetter, Christian Koch, Jonathan D. Kiefer, Celeste Gobbi, Francesco Manfredi, Kathrin Zimmermann, Philipp Kaufmann, Serena Fazio, Christian Pellegrino, Norman F. Russkamp, Danielle Villars, Mattia Matasci, Monique Maurer, Jan Mueller, Florin Schneiter, Paul Büschl, Niclas Harrer, Jacqueline Mock, Stefan Balabanov, César Nombela‐Arrieta, Timm Schroeder, Dario Neri, Markus G. Manz
Publikováno v:
HemaSphere, Vol 8, Iss 11, Pp n/a-n/a (2024)
Abstract Acute myeloid leukemia (AML) derives from hematopoietic stem and progenitor cells (HSPCs). To date, no AML‐exclusive, non‐HSPC‐expressed cell‐surface target molecules for AML selective immunotherapy have been identified. Therefore, t
Externí odkaz:
https://doaj.org/article/f01601fd49bb490c81391fc86db051b9
Autor:
Markus G. Klammer, Laura Reimann, Oskar Richter, Simone Lieschke, Helena Stengl, Simon Hellwig, Ramanan Ganeshan, Maximilian Schöls, Alexander Nelde, Christian Meisel, Kersten Villringer, Christian H. Nolte, Matthias Endres, Jan Friedrich Scheitz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)
Background Atrial fibrillation detected after stroke (AFDAS) is considered to be a distinct entity influenced by cardiogenic and neurogenic factors. We hypothesized that patients with AFDAS have larger stroke lesions than patients without atrial fibr
Externí odkaz:
https://doaj.org/article/7e1e2a50f38d4ed9a5dcb40960f7a5c2
Autor:
Miaomiao Sun, Michael Weller, Tobias Weiß, Dario Neri, Emanuele Puca, Thomas Look, Cesare Di Nitto, Eleonora Prodi, Roberto De Luca, Markus G. Manz, Ettore Gilardoni, Christian Pellegrino, Domenico Ravazza, Vlad Moisoiu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Anti-PD-1 antibodies have revolutionized cancer immunotherapy due to their ability to induce long-lasting complete remissions in a proportion of patients. Current research efforts are attempting to identify biomarkers and suitable combinat
Externí odkaz:
https://doaj.org/article/548220fc139c4b18925463682f754520
A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Frauke Seehusen, Abdullah Elsayed, Emanuele Puca, Roberto De Luca, Christian Pellegrino, Thomas Look, Tobias Weiss, Markus G Manz, Cornelia Halin, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 904-926 (2024)
Abstract Cytokine-based therapeutics have been shown to mediate objective responses in certain tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents dose escalation to therapeutically active regimens. The a
Externí odkaz:
https://doaj.org/article/3f9295ee87c944c5ae3975d61e53a157
Autor:
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre PA Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus G Manz, Steffen Boettcher
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 445-474 (2024)
Abstract TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option f
Externí odkaz:
https://doaj.org/article/3995291a6c424aeaadea031a81b64f56
Autor:
Robert J. H. Dunn, Nicholas Herold, Lisa V. Alexander, Markus G. Donat, Rob Allan, Margot Bador, Manola Brunet, Vincent Cheng, Wan Maisarah Wan Ibadullah, Muhammad Khairul Izzat Bin Ibrahim, Andries Kruger, Hisayuki Kubota, Tanya J. R. Lippmann, Jose Marengo, Sifiso Mbatha, Simon McGree, Sandile Ngwenya, Jose Daniel Pabon Caicedo, Andrea Ramos, Jim Salinger, Gerard van derSchrier, Arvind Srivastava, Blair Trewin, Ricardo Vásquez Yáñez, Jorge Vazquez‐Aguirre, Claudia Villaroel Jiménez, Russ Vose, Mohd Noor’Arifin Bin Hj Yussof, Xuebin Zhang
Publikováno v:
Earth and Space Science, Vol 11, Iss 4, Pp n/a-n/a (2024)
Abstract Global gridded data sets of observed extremes indices underpin assessments of changes in climate extremes. However, similar efforts to enable the assessment of indices relevant to different sectors of society have been missing. Here we prese
Externí odkaz:
https://doaj.org/article/d1ce1c9c64384eba8a6c45a2a2570598
Autor:
Cynthia Stapornwongkul, Alexandra Nieters, Paulina Staus, Stephan Rusch, Anita Delor, Ulrich Baumann, Julius Wehrle, Melanie Boerries, Markus G. Seidel, Bodo Grimbacher, Gerhard Kindle
Publikováno v:
Journal of Health Monitoring, Vol 8, Iss 4, Pp 24-30 (2023)
Background: Patient registries are an important tool for networking medical caregivers and research, especially in the field of rare diseases. Individuals afflicted by multi-organ autoimmune diseases typically suffer from inflammation of multiple org
Externí odkaz:
https://doaj.org/article/24b4660c2fa9423a940b3d97c74997ad