Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Markus Enzelberger"'
Autor:
Yvonne Stark, Stefan Kaden, Dominique Poujol, Daniela Daubert, Karin Felderer, Jennifer Stehle, Katja Siegers, Stefanie Urlinger, Tanja Herrmann, Ingrid Schuster, Ralf Strohner, Johanna Kölln, Martin Heßling, Markus Enzelberger, Thomas Tiller, Dorothée Deppe, Marion Berenguer
Publikováno v:
mAbs
This report describes the design, generation and testing of Ylanthia, a fully synthetic human Fab antibody library with 1.3E+11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) variable heavy (VH)/variable light (VL) chain pairs, which cover a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13e70c347531d280c6341065e3428a0
https://doi.org/10.4161/mabs.24218
https://doi.org/10.4161/mabs.24218
Autor:
Paul W. H. I. Parren, Markus Enzelberger, John M. Lambert, Paul Carter, Mary Reilly, Tim Jones, John McCafferty, David C. Lowe, Mike Clark, Julian Davies, Dimiter S. Dimitrov, Max Vásquez, Isidro Hötzel, Robert G.E. Holgate, Jane A. Gross, Bassil I. Dahiyat, Kerry A. Chester, Matthew P. Baker, Martin Steegmaier, John S. Haurum, Martin J. Glennie, Victoria C. Smith, Dennis R. Burton, Richard A.J. Janssen, Stefan Dübel, Andrew George Popplewell, Hendrik J. Rademaker, Andrew Bradbury, Andreas Plückthun, Herren Wu, Thomas Schirrmann, S. L. Martin, Adam Walker, James S. Huston
Publikováno v:
mAbs, 8(1), 1-9
mAbs
mAbs
An important step in drug development is the assignment of an International Nonproprietary Name (INN) by the World Health Organization (WHO) that provides healthcare professionals with a unique and universally available designated name to identify ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55402fa482d0701933474f61cc2ce70
http://hdl.handle.net/1887/106996
http://hdl.handle.net/1887/106996
Autor:
Markus Enzelberger, Johanna Kölln, Stefanie Urlinger, Marion Bauer, Andreas Popp, Yvonne Stark, Josef Prassler, Stefanie Thiel, Andrea Polzer, Catrin Pracht, Solveig Peters, Stephanie Nörenberg
Publikováno v:
Journal of Molecular Biology. 413:261-278
This article describes the design of HuCAL (human combinatorial antibody library) PLATINUM, an optimized, second-generation, synthetic human Fab antibody library with six trinucleotide-randomized complementarity-determining regions (CDRs). Major impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8962f65f58bc578f3eea4f146ba529b
https://doi.org/10.1016/j.jmb.2011.08.012
https://doi.org/10.1016/j.jmb.2011.08.012
Publikováno v:
Analytical Chemistry. 77:2727-2732
pHluorin, a pH-sensitive mutant of green fluorescent protein (GFP), acts as a sensor for intracellular pH shifts, triggered by hydrolytic enzymes. This principle was used to develop a pHluorin-based in vivo assay for hydrolase screening. The presente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f9201f4e1ab9b4b6514ff6b078fbbe
https://doi.org/10.1021/ac0486692
https://doi.org/10.1021/ac0486692
Publikováno v:
Science. 300:955-958
We demonstrate microscopic fluidic control and memory elements through the use of an aqueous viscoelastic polymer solution as a working fluid. By exploiting the fluid's non-Newtonian rheological properties, we were able to demonstrate both a flux sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d501b76b85352b9dd5adbb90c683b2
https://doi.org/10.1126/science.1083694
https://doi.org/10.1126/science.1083694
Publikováno v:
Sensors and Actuators A: Physical. 104:25-31
We describe a new approach for miniaturizing spectrometers by combining replica molded elastomeric micro-channels with filtered silicon detector arrays. Elastomers are excellent transparent materials, which provide hermetic seals to silicon dioxide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d13e3eae23a94ea7b9d94cd94c3eed
https://doi.org/10.1016/s0924-4247(02)00477-6
https://doi.org/10.1016/s0924-4247(02)00477-6
Autor:
Alessandra Mezzetti, Markus Enzelberger, Romas J. Kazlauskas, Neil A. Somers, Rolf D. Schmid, Frank Zocher, Geoff P. Horsman, Uwe T. Bornscheuer, Andrew Man Fai Liu, Claudia Schmidt-Dannert, Terry S Brush
Publikováno v:
Tetrahedron: Asymmetry. 12:545-556
Recent advances in biochemistry and molecular biology have simplified the discovery and preparation of new hydrolases. Although these hydrolases might solve problems in organic synthesis, measuring their selectivity, especially enantioselectivity, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999744204ffcf6a36fc17e0a5c2fa2ef
https://doi.org/10.1016/s0957-4166(01)00072-6
https://doi.org/10.1016/s0957-4166(01)00072-6
Publikováno v:
Analytica Chimica Acta. 391:345-351
A UV/VIS spectrophotometric microtiter-plate and a filter-paper based assay using 4-( p -nitrobenzyl)pyridine (NBP) were developed to determine epoxide hydrolytic activity by measuring the decrease of the epoxide concentration. Both systems were appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271c9c909334af87af17e5dd5e707115
https://doi.org/10.1016/s0003-2670(99)00216-0
https://doi.org/10.1016/s0003-2670(99)00216-0
Publikováno v:
Journal of Biotechnology. 61:75-78
In this paper we report on the lipase-catalyzed preparation of enantiopure amines. Hydrolysis of two different (R,S)-[1-(4-chlorophenyl)] ethyl amides was best performed in phosphate buffer, resulting in conversions ∼48% and optical purities of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f40435bfc9099a7d385c95bbe3c6601c
https://doi.org/10.1016/s0168-1656(97)00198-3
https://doi.org/10.1016/s0168-1656(97)00198-3
Publikováno v:
Journal of Biotechnology. 56:129-133
Lipase-catalysed stereoselective hydrolysis of a family of saturated γ- and δ-lactones was investigated. Increasing the chain length from δ-octalactone to δ-dodecalactone leads to higher enantiomeric excess. Best results were found using a lipase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b5e2f89aca4750aa6f8eef398ccae27
https://doi.org/10.1016/s0168-1656(97)00107-7
https://doi.org/10.1016/s0168-1656(97)00107-7