Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Markus Damme"'
Autor:
Zoë P. Van Acker, Anika Perdok, Ruben Hellemans, Katherine North, Inge Vorsters, Cedric Cappel, Jonas Dehairs, Johannes V. Swinnen, Ragna Sannerud, Marine Bretou, Markus Damme, Wim Annaert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connect
Externí odkaz:
https://doaj.org/article/293aabf59d5247c19a7f1c12925e6771
Autor:
Anne-Sophie Cabron, Uwe Borgmeyer, Julia Richter, Helga Peisker, Katharina Gutbrod, Peter Dörmann, Anja Capell, Markus Damme
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Genetic variants in TMEM106B are a common risk factor for frontotemporal lobar degeneration and the most important modifier of disease risk in patients with progranulin (GRN) mutations (FTLD-GRN). TMEM106B is encoding a lysosomal transmembra
Externí odkaz:
https://doaj.org/article/16fa8d32c9a846b2901774631f5e6e59
Autor:
Marko Roblek, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck, Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, Daria E. Siekhaus
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier Major Facilitator Superfamily Domain-containing protein 1 (MFSD1) in the regula
Externí odkaz:
https://doaj.org/article/ed86311871294197b5ee5a4232875d03
Autor:
Tobias Becker, Cedric Cappel, Francesco Di Matteo, Giovanna Sonsalla, Ewelina Kaminska, Fabio Spada, Silvia Cappello, Markus Damme, Pavel Kielkowski
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103521- (2021)
Summary: Protein AMPylation is a posttranslational modification with an emerging role in neurodevelopment. In metazoans two highly conserved protein AMP-transferases together with a diverse group of AMPylated proteins have been identified using chemi
Externí odkaz:
https://doaj.org/article/bc9c70440d9c4ad18ed70a8933b5cba5
Autor:
Lars P Lunding, Daniel Krause, Guido Stichtenoth, Cordula Stamme, Niklas Lauterbach, Jan Hegermann, Matthias Ochs, Björn Schuster, Radislav Sedlacek, Paul Saftig, Dominik Schwudke, Michael Wegmann, Markus Damme
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009619 (2021)
Lysosome-associated membrane glycoprotein 3 (LAMP3) is a type I transmembrane protein of the LAMP protein family with a cell-type-specific expression in alveolar type II cells in mice and hitherto unknown function. In type II pneumocytes, LAMP3 is lo
Externí odkaz:
https://doaj.org/article/530766cbc3c546f5bac9311145dd3f03
Autor:
Mukhran Khundadze, Federico Ribaudo, Adeela Hussain, Jan Rosentreter, Sandor Nietzsche, Melanie Thelen, Dominic Winter, Birgit Hoffmann, Muhammad Awais Afzal, Tanja Hermann, Cecilia de Heus, Eva-Maria Piskor, Christian Kosan, Patricia Franzka, Lisa von Kleist, Tobias Stauber, Judith Klumperman, Markus Damme, Tassula Proikas-Cezanne, Christian A. Hübner
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 419-431 (2019)
Hereditary spastic paraplegia is a spastic gait disorder that arises from degeneration of corticospinal axons. The subtype SPG48 is associated with mutations in the zeta subunit of the adaptor protein complex five (AP5). AP5 function and the pathophy
Externí odkaz:
https://doaj.org/article/c5d0d4197e294f66a8340361edbe5c4c
Autor:
Patrick Lüningschrör, Georg Werner, Stijn Stroobants, Soichiro Kakuta, Benjamin Dombert, Daniela Sinske, Renate Wanner, Renate Lüllmann-Rauch, Benedikt Wefers, Wolfgang Wurst, Rudi D’Hooge, Yasuo Uchiyama, Michael Sendtner, Christian Haass, Paul Saftig, Bernd Knöll, Anja Capell, Markus Damme
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3506-3519.e6 (2020)
Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiol
Externí odkaz:
https://doaj.org/article/6a9f42b14fca4fb8a5526634d9334b2c
Autor:
David Massa López, Melanie Thelen, Felix Stahl, Christian Thiel, Arne Linhorst, Marc Sylvester, Irm Hermanns-Borgmeyer, Renate Lüllmann-Rauch, Winnie Eskild, Paul Saftig, Markus Damme
Publikováno v:
eLife, Vol 8 (2019)
Lysosomes are major sites for intracellular, acidic hydrolase-mediated proteolysis and cellular degradation. The export of low-molecular-weight catabolic end-products is facilitated by polytopic transmembrane proteins mediating secondary active or pa
Externí odkaz:
https://doaj.org/article/74b437a01c4045349afd71c5702c4170
Autor:
Adriana Carolina Gonzalez, Michaela Schweizer, Sebastian Jagdmann, Christian Bernreuther, Thomas Reinheckel, Paul Saftig, Markus Damme
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 1040-1053 (2018)
Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late-onset Alzheimer's disease. We present a detailed biochemical analysis of PLD3 and reveal its endogenous localization in endosomes and lysosomes. PLD3 reaches lysosomes
Externí odkaz:
https://doaj.org/article/00124dbdcb1b4912be1f0d63d9bba588
Autor:
Stijn Stroobants, Markus Damme, Ann Van der Jeugd, Ben Vermaercke, Claes Andersson, Jens Fogh, Paul Saftig, Judith Blanz, Rudi D'Hooge
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 255-268 (2017)
Alpha-mannosidosis is a glycoproteinosis caused by deficiency of lysosomal acid alpha-mannosidase (LAMAN), which markedly affects neurons of the central nervous system (CNS), and causes pathognomonic intellectual dysfunction in the clinical condition
Externí odkaz:
https://doaj.org/article/69731922a1654397bfd10619a9c92c07