The Fungal Quorum-Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity

Autor: Ines Leonhardt, Steffi Spielberg, Michael Weber, Daniela Albrecht-Eckardt, Markus Bläss, Ralf Claus, Dagmar Barz, Kirstin Scherlach, Christian Hertweck, Jürgen Löffler, Kerstin Hünniger, Oliver Kurzai

Publikováno v: mBio, Vol 6, Iss 2 (2015)

ABSTRACT Farnesol, produced by the polymorphic fungus Candida albicans, is the first quorum-sensing molecule discovered in eukaryotes. Its main function is control of C. albicans filamentation, a process closely linked to pathogenesis. In this study,

Externí odkaz: https://doaj.org/article/6497b293fb4646f19f117bfd66ba9845

Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes

Autor: Iglika K Djoumerska-Alexieva, Srini V. Kaveri, Elisaveta Voynova, Nina Ivanovska, Ralf A. Claus, Catherine Fitting, Tchavdar Vassilev, Jean-Marc Cavaillon, Jordan D. Dimitrov, Clemens L. Bockmeyer, Markus Bläss, Michael Bauer, Zvetanka Stefanova, Petya Dimitrova, Sandro Lindig, Stephan von Gunten, Maya Hadzhieva, Anastas Pashov, Lubka T. Roumenina

Publikováno v: Molecular Medicine
Molecular Medicine, 2015, 21 (1), pp.1002-1010. ⟨10.2119/molmed.2014.00224⟩
Mol Med
Molecular Medicine, Feinstein Institute for Medical Research, 2015, 21 (1), pp.1002-1010. ⟨10.2119/molmed.2014.00224⟩
Molecular Medicine, Feinstein Institute for Medical Research, 2015, 21 (1), pp.1002-1010. 〈10.2119/molmed.2014.00224〉

International audience; Sepsis is a major cause for death worldwide. Numerous interventional trials with agents neutralizing single pro-inflammatory mediators have failed to improve survival in sepsis and aseptic systemic inflammatory response syndro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96cf9f27bfc71936ad643938ce9a079
https://hal-pasteur.archives-ouvertes.fr/pasteur-01450975/document

Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction

Autor: Ralf A. Claus, Matthias Kohl, Andrea Schrepper, Ha-Yeun Chung, Amelie Lupp, Markus Bläss, Markus H. Gräler, Sebastian Stehr, Anna S Kollmey

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 839

Cardiac dysfunction, in particular of the left ventricle, is a common and early event in sepsis, and is strongly associated with an increase in patients’ mortality. Acid sphingomyelinase (SMPD1)—the principal regulator for rapid and transient gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5dfad16aec0acba6e3f000f8638bde
https://doi.org/10.3390/ijms18040839