Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Markus Bauser"'
Autor:
Andreas Unterberg, Hartmut Rehwinkel, Ann Christin Beck, Felix Sahm, Michael Platten, Daniel Schrimpf, Stefan Kaulfuss, Wolfgang Wick, Olaf Panknin, Holger Hess-Stumpp, Roland Neuhaus, Roman C. Hillig, Judith Guenther, David Capper, Andrea Haegebart, Luisella Toschi, Markus Bauser, Stefan Pusch, Manfred Jugold, Martina Ott, Christel Herold-Mende, Katja Zimmermann, Jörg Balss, Jessica Eisel, Sonja Krausert, Viktoria Eichwald, Viktoria Fischer, Andreas von Deimling
Publikováno v:
Acta Neuropathologica. 133:629-644
Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic cholangiocarcinoma. These mutations result in a neomorphic enzyme specificity which leads to a dramatic
Autor:
Damian Stichel, M M Araujo-Cruz, Lara Klett, Amar Deep Sharma, Stefan Kaulfuss, Luisella Toschi, A. von Deimling, Anuhar Chaturvedi, A Bakkali, Ramya Goparaju, Robert Geffers, Stefan Pusch, Razif Gabdoulline, Eduard A. Struys, Anthony D. Ho, Arnold Ganser, Katja Zimmermann, Tilmann Bochtler, Felicitas Thol, Hartmut Rehwinkel, Alwin Krämer, Lena Herbst, Andrea Haegebarth, Roland Neuhaus, Karsten Rippe, Markus Bauser, Olaf Panknin, Michael Heuser, Holger Hess-Stumpp
Publikováno v:
Leukemia, 31(10), 2020-2028. Nature Publishing Group
Chaturvedi, A, Herbst, L, Pusch, S, Klett, L, Goparaju, R, Stichel, D, Kaulfuss, S, Panknin, O, Zimmermann, K, Toschi, L, Neuhaus, R, Haegebarth, A, Rehwinkel, H, Hess-Stumpp, H, Bauser, M, Bochtler, T, Struys, E A, Sharma, A, Bakkali, A, Geffers, R, Araujo-Cruz, M M, Thol, F, Gabdoulline, R, Ganser, A, Ho, A D, Von Deimling, A, Rippe, K, Heuser, M & Krämer, A 2017, ' Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo ', Leukemia, vol. 31, no. 10, pp. 2020-2028 . https://doi.org/10.1038/leu.2017.46
Leukemia
Chaturvedi, A, Herbst, L, Pusch, S, Klett, L, Goparaju, R, Stichel, D, Kaulfuss, S, Panknin, O, Zimmermann, K, Toschi, L, Neuhaus, R, Haegebarth, A, Rehwinkel, H, Hess-Stumpp, H, Bauser, M, Bochtler, T, Struys, E A, Sharma, A, Bakkali, A, Geffers, R, Araujo-Cruz, M M, Thol, F, Gabdoulline, R, Ganser, A, Ho, A D, Von Deimling, A, Rippe, K, Heuser, M & Krämer, A 2017, ' Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo ', Leukemia, vol. 31, no. 10, pp. 2020-2028 . https://doi.org/10.1038/leu.2017.46
Leukemia
Background: Mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) are frequently found in patients with acute myeloid leukemia (AML) and several other tumors. Mutant IDH1 produces R-2-hydroxyglutarate (R-2HG), which induces histone and