Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Markus Ball"'
Autor:
Michael Menzel, Martina Kirchner, Klaus Kluck, Markus Ball, Susanne Beck, Michael Allgäuer, Christin Assmann, Johannes Schnorbach, Anna‐Lena Volckmar, Timothy Kwang Yong Tay, Hannah Goldschmid, Daniel SW Tan, Michael Thomas, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger, Petros Christopoulos
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract This study analyzed whether extended molecular profiling can predict the development of epidermal growth factor receptor (EGFR) gene T790M mutation, which is the most frequent resistance alteration in non‐small cell lung cancer (NSCLC) aft
Externí odkaz:
https://doaj.org/article/592032d0cf624a62bd5f0cb57fe2198c
Autor:
Maria Pouyiourou, Bianca N. Kraft, Timothy Wohlfromm, Michael Stahl, Boris Kubuschok, Harald Löffler, Ulrich T. Hacker, Gerdt Hübner, Lena Weiss, Michael Bitzer, Thomas Ernst, Philipp Schütt, Thomas Hielscher, Stefan Delorme, Martina Kirchner, Daniel Kazdal, Markus Ball, Klaus Kluck, Albrecht Stenzinger, Tilmann Bochtler, Alwin Krämer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-based chemotherapy. 10-20% of patients have a high tumor mutational burden (TMB), which predicts response to immunotherapy in many cancer types. In th
Externí odkaz:
https://doaj.org/article/cf29f4d0ded648268fe0196b4aa79152
Autor:
Michael Menzel, Stephan Ossowski, Sebastian Kral, Patrick Metzger, Peter Horak, Ralf Marienfeld, Melanie Boerries, Steffen Wolter, Markus Ball, Olaf Neumann, Sorin Armeanu-Ebinger, Christopher Schroeder, Uta Matysiak, Hannah Goldschmid, Vincent Schipperges, Axel Fürstberger, Michael Allgäuer, Timo Eberhardt, Jakob Niewöhner, Andreas Blaumeiser, Carolin Ploeger, Tobias Bernd Haack, Timothy Kwang Yong Tay, Olga Kelemen, Thomas Pauli, Martina Kirchner, Klaus Kluck, Alexander Ott, Marcus Renner, Jakob Admard, Axel Gschwind, Silke Lassmann, Hans Kestler, Falko Fend, Anna Lena Illert, Martin Werner, Peter Möller, Thomas Theodor Werner Seufferlein, Nisar Malek, Peter Schirmacher, Stefan Fröhling, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmenta
Externí odkaz:
https://doaj.org/article/c80cfb96a9be48f6bbb8329e92275143
Autor:
Eva Romanovsky, Klaus Kluck, Iordanis Ourailidis, Michael Menzel, Susanne Beck, Markus Ball, Daniel Kazdal, Petros Christopoulos, Peter Schirmacher, Thorsten Stiewe, Albrecht Stenzinger, Jan Budczies
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract TP53 is the most frequently mutated gene in human cancer. While no TP53-targeting drugs have been approved in the USA or Europe so far, preclinical and clinical studies are underway to investigate targeting of specific or all TP53 mutations,
Externí odkaz:
https://doaj.org/article/e0d3071184164fcd99aee54c2807f01b
Autor:
Michael Menzel, Volker Endris, Constantin Schwab, Klaus Kluck, Olaf Neumann, Susanne Beck, Markus Ball, Christian Schaaf, Stefan Fröhling, Peter Lichtner, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger, Jan Budczies
Publikováno v:
Translational Oncology, Vol 35, Iss , Pp 101706- (2023)
Homologous recombination deficiency (HRD) is a predictive marker for response to poly (ADP-ribose) polymerase inhibitors (PARPi) in ovarian carcinoma. HRD scores have entered routine diagnostics, but the influence of algorithms, parameters and confou
Externí odkaz:
https://doaj.org/article/4e88daf2b11f4936876a9802128bc881
Autor:
Carina Heydt, Jan Rehker, Roberto Pappesch, Theresa Buhl, Markus Ball, Udo Siebolts, Anja Haak, Philipp Lohneis, Reinhard Büttner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Outcome of immune checkpoint inhibition in cancer can be predicted by measuring PDL1 expression of tumor cells. Search for additional biomarkers led to tumor mutational burden (TMB) as surrogate marker for neoantigens presented. While TMB wa
Externí odkaz:
https://doaj.org/article/9ffba0af5f5c4416968c0b58a4842a72
Autor:
Carina Heydt, Ann-Kathrin Becher, Svenja Wagener-Ryczek, Markus Ball, Anne M. Schultheis, Simon Schallenberg, Vanessa Rüsseler, Reinhard Büttner, Sabine Merkelbach-Bruse
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1339-1347 (2019)
In EGFR-treatment naive NSCLC patients, high-level MET amplification is detected in approximately 2–3% and is considered as adverse prognostic factor. Currently, clinical trials with two different inhibitors, capmatinib and tepotinib, are under way
Externí odkaz:
https://doaj.org/article/1d0261c414844447ae380ed7d10134fd
Autor:
Andreas G. Nerlich, Raffaella Bianucci, Anna Trisciuoglio, Gabriele Schönian, Markus Ball, Valentina Giuffra, Beatrice Bachmeier, Carsten M. Pusch, Ezio Ferroglio, Gino Fornaciari
Publikováno v:
Emerging Infectious Diseases, Vol 18, Iss 1, Pp 184-186 (2012)
Externí odkaz:
https://doaj.org/article/7fdfbe69d3f541cbbc1d253278967f1d
Autor:
Albert Lalremruata, Markus Ball, Raffaella Bianucci, Beatrix Welte, Andreas G Nerlich, Jürgen F J Kun, Carsten M Pusch
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60307 (2013)
Due to the presence of the lake Quarun and to the particular nature of its irrigation system, it has been speculated that the Fayum, a large depression 80 kilometers south-west of modern Cairo, was exposed to the hazards of malaria in historic times.
Externí odkaz:
https://doaj.org/article/1515afa126154ca585521a0a5f81e373
Autor:
Claudia Vollbrecht, Inga Hoffmann, Annika Lehmann, Sabine Merkelbach-Bruse, Jana Fassunke, Svenja Wagener-Ryczek, Markus Ball, Lora Dimitrova, Arndt Hartmann, Robert Stöhr, Ramona Erber, Wilko Weichert, Nicole Pfarr, Lisa Bohlmann, Andreas Jung, Wolfgang Dietmaier, Manfred Dietel, David Horst, Michael Hummel
Publikováno v:
Virchows Archiv. 482:697-706
Precision oncology based on specific molecular alterations requires precise and reliable detection of therapeutic targets in order to initiate the optimal treatment. In many European countries—including Germany—assays employed for this purpose ar