Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Markus A Hölzl"'
Autor:
Johannes J Kovarik, Elisabeth Kernbauer, Markus A Hölzl, Johannes Hofer, Guido A Gualdoni, Klaus G Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-Söllner, Marcus D Säemann, Thomas Decker, Gerhard J Zlabinger
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180900 (2017)
A crucial role of cell metabolism in immune cell differentiation and function has been recently established. Growing evidence indicates that metabolic processes impact both, innate and adaptive immunity. Since a down-stream integrator of metabolic al
Externí odkaz:
https://doaj.org/article/33afdf10a5a6407d9ac73f22e42348bd
Autor:
Chiara Borsotti, Nichole M. Danzl, Grace Nauman, Markus A. Hölzl, Clare French, Estefania Chavez, Mohsen Khosravi-Maharlooei, Salome Glauzy, Fabien R. Delmotte, Eric Meffre, David G. Savage, Sean R. Campbell, Robin Goland, Ellen Greenberg, Jing Bi, Prakash Satwani, Suxiao Yang, Joan Bathon, Robert Winchester, Megan Sykes
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2007-2018 (2017)
Abstract: B cells play a major role in antigen presentation and antibody production in the development of autoimmune diseases, and some of these diseases disproportionally occur in females. Moreover, immune responses tend to be stronger in female vs
Externí odkaz:
https://doaj.org/article/72da05736802495ebfbfad73ddbd936c
Autor:
Grace Nauman, Nichole M. Danzl, Jaeyop Lee, Chiara Borsotti, Rachel Madley, Jianing Fu, Markus A. Hölzl, Alexander Dahmani, Akaitz Dorronsoro Gonzalez, Éstefania Chavez, Sean R. Campbell, Suxiao Yang, Prakash Satwani, Kang Liu, Megan Sykes
Publikováno v:
J Immunol
Immunodeficient mice reconstituted with immune systems from patients, or personalized immune (PI) mice, are powerful tools for understanding human disease. Compared with immunodeficient mice transplanted with human fetal thymus tissue and fetal liver
Autor:
Markus A. Hölzl, Hannes Stockinger, David E. Isenman, Georg A. Böhmig, Judith Leitner, Peter Steinberger, Gerhard J. Zlabinger, Florian Forster, Johannes J. Kovarik, Johannes Hofer, Markus Wahrmann
Publikováno v:
The FASEB Journal. 30:1492-1503
Complement regulation leads to the generation of complement split products (CSPs) such as complement component (C)4d, a marker for disease activity in autoimmune syndromes or antibody-mediated allograft rejection. However, the physiologic role of C4d
Publikováno v:
Transplantation. 98:1158-1164
BACKGROUND CTLA-4 immunoglobulin fusion proteins (CTLA4-Ig) suppress immune reactions by blocking the T-cell costimulatory CD28-CD80-86 pathway and are used in clinical trials for diseases featuring exaggerated T-cell reactivity including autoimmune
Autor:
Diana Mechtcheriakova, Petra Waidhofer-Söllner, René Koeffel, Markus A. Hölzl, Johannes J. Kovarik, Yury Sobanov, Johannes Hofer, Gerhard J. Zlabinger, Marcus D. Säemann
Publikováno v:
Immunology. 139:395-405
n-Butyrate deriving from bacterial fermentation in the mammalian intestine is a key determinant in gastrointestinal homeostasis. We examined the effects of this short-chain fatty acid and Toll-like receptor 2 (TLR) and TLR4 engagement on inflammatory
Autor:
Peter Steinberger, Johannes J. Kovarik, Alexander Goihl, Johannes Hofer, Dirk Roggenbuck, Dirk Reinhold, Markus A. Hölzl, Gerhard J. Zlabinger, M. Gärtner
Publikováno v:
Cellular Immunology
The pancreatic zymogen granule membrane protein (GP2) is expressed by pancreatic acinar cells and M cells of the ileum. GP2 is the closest related homologue of the urine resident Tamm–Horsfall protein (THP). Recently, it was shown that THP is a lig
Autor:
Harald Heinzl, Marcus D. Säemann, Johannes J. Kovarik, Johannes Hofer, Markus A. Hölzl, Gerhard J. Zlabinger, Wolfgang Tillinger
Publikováno v:
European Journal of Clinical Investigation. 41:291-298
Eur J Clin Invest 2011; 41 (3): 291–298 Abstract Background The intestinal mucosa of patients with inflammatory bowel diseases (IBD) characteristically shows a high degree of inflammation when compared to healthy subjects. This appears to be attrib
Autor:
H. Bernheimer, M. Gärtner, Markus A. Hölzl, Gere Sunder-Plassmann, Gerhard J. Zlabinger, Johannes J. Kovarik, Johannes Hofer
Publikováno v:
Clinica Chimica Acta. 411:1666-1670
Background Mutations of the α-galactosidase (α-Gal) A gene in Fabry disease lead to a severe disturbance in glycosphingolipid catabolism. The atypical clinical picture of Fabry disease hampers diagnosis, resulting in a delayed start of therapy. Cur
Autor:
Gerhard J. Zlabinger, Katharina Pfistershammer, Markus A. Hölzl, Peter Steinberger, Johannes Hofer
Publikováno v:
Immunology Letters. 119:4-11
Host defense mechanisms are multilayered and involve physical as well as chemical barriers, antimicrobial factors as well as a broad set of immunocompetent cells. The mode of action of antimicrobial factors is variable, ranging from opsonisation and