Zobrazeno 1 - 10
of 681
pro vyhledávání: '"Markus Grompe"'
Autor:
Sunghee Chai, Leslie Wakefield, Mason Norgard, Bin Li, David Enicks, Daniel L. Marks, Markus Grompe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 504-512 (2023)
Significant progress has been made in developing recombinant adeno-associated virus (rAAV) for clinical gene therapy. While rAAV is a versatile gene delivery platform, its packaging limit of 4.7 kb limits the diseases it can target. Here, we report t
Externí odkaz:
https://doaj.org/article/c252d3e783894ccdac510a2d819e2d03
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here, authors show that precise integration of an rAAV vector into a chromosomal target locus results in expression of a self-cleaving guide RNA. This recombination event creates genetic resistance to a hepatotoxic compound and enables in vivo expans
Externí odkaz:
https://doaj.org/article/4d08ffa6f2c04842bf58c6c359692c38
Autor:
Makiko Mochizuki-Kashio, Noriko Otsuki, Kota Fujiki, Sherif Abdelhamd, Peter Kurre, Markus Grompe, Atsushi Iwama, Kayoko Saito, Ayako Nakamura-Ishizu
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Fanconi Anemia (FA) is an inherited bone marrow (BM) failure disorder commonly diagnosed during school age. However, in murine models, disrupted function of FA genes leads to a much earlier decline in fetal liver hematopoietic stem cell (FL HSC) numb
Externí odkaz:
https://doaj.org/article/1549e69d8d5b4516bf6cdb405a36854c
Autor:
Mina Ogawa, Jia-Xin Jiang, Sunny Xia, Donghe Yang, Avrilynn Ding, Onofrio Laselva, Marcela Hernandez, Changyi Cui, Yuichiro Higuchi, Hiroshi Suemizu, Craig Dorrell, Markus Grompe, Christine E. Bear, Shinichiro Ogawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Current protocols to generate cholangiocytes from human pluripotent cells produce immature cells. Here the authors identify retinoic acid, BMP, cAMP and Rho kinase pathways as regulators of cholangiocyte maturation, and generate ciliated cholangiocyt
Externí odkaz:
https://doaj.org/article/e2c37e554f8c4d829b4039f62abf625f
Autor:
Tomonori Matsumoto, Leslie Wakefield, Alexander Peters, Myron Peto, Paul Spellman, Markus Grompe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The involvement of polyploid hepatocytes in liver tumorigenesis is unclear. Here the authors use in vivo lineage tracing and show that polyploid hepatocytes initiate tumour formation through frequent ploidy reduction.
Externí odkaz:
https://doaj.org/article/6740ee9eb13f4308b1052f02c670e913
Autor:
Daelyn Y. Richards, Shelley R. Winn, Sandra Dudley, Sean Nygaard, Taylor L. Mighell, Markus Grompe, Cary O. Harding
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 234-245 (2020)
Phenylketonuria (PKU) due to recessively inherited phenylalanine hydroxylase (PAH) deficiency results in hyperphenylalaninemia, which is toxic to the central nervous system. Restriction of dietary phenylalanine intake remains the standard of PKU care
Externí odkaz:
https://doaj.org/article/00c24d618a90462583b0b34d2cc5a04d
Autor:
Bin Li, Yuhan Wang, Carl Pelz, Josh Moss, Ruth Shemer, Yuval Dor, Yassmine K. Akkari, Pamela S. Canady, Willscott E. Naugler, Susan Orloff, Markus Grompe
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102523- (2021)
Background & aims: Mature hepatocytes have limited expansion capability in culture and rapidly loose key functions. Recently however, tissue culture conditions have been developed that permit rodent hepatocytes to proliferate and transform into proge
Externí odkaz:
https://doaj.org/article/8a43b9dd01524af5888516e470070fb3
Autor:
Hiep Tai Nguyen, Weiliang Tang, Andrew L. H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin, Khashayar Roohollahi, Madeline Fritzke, Elizabeth E. Hoskins, Erica Jonlin, Leslie Wakefield, Lucas B. Sullivan, Eleanor Y. Chen, Josephine Dorsman, Ruud Brakenhoff, Amanda G. Paulovich, Markus Grompe, Ramon Garcia‐Escudero, Susanne I. Wells, Agata Smogorzewska, Raymond J. Monnat
Publikováno v:
International Journal of Cancer, 153(1), 183-196. Wiley-Liss Inc.
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Nguyen, H T, Tang, W, Webster, A L H, Whiteaker, J R, Chandler, C M, Errazquin, R, Roohollahi, K, Fritzke, M, Hoskins, E E, Jonlin, E, Wakefield, L, Sullivan, L B, Chen, E Y, Dorsman, J, Brakenhoff, R, Paulovich, A G, Grompe, M, Garcia-Escudero, R, Wells, S I, Smogorzewska, A & Monnat, R J 2023, ' Fanconi anemia-isogenic head and neck cancer cell line pairs : A basic and translational science resource ', International Journal of Cancer, vol. 153, no. 1, pp. 183-196 . https://doi.org/10.1002/ijc.34506
Fanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of developing carcinomas arising in squamous mucosal epithelia lining the mouth, proximal esophagus, vulva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015dddfce92f17afb210d60a0683723
https://doi.org/10.1002/ijc.34506
https://doi.org/10.1002/ijc.34506
Autor:
Samantha L. Ginn, Anais K. Amaya, Sophia H.Y. Liao, Erhua Zhu, Sharon C. Cunningham, Michael Lee, Claus V. Hallwirth, Grant J. Logan, Szun S. Tay, Anthony J. Cesare, Hilda A. Pickett, Markus Grompe, Kimberley Dilworth, Leszek Lisowski, Ian E. Alexander
Publikováno v:
JHEP Reports, Vol 2, Iss 1, Pp - (2020)
Background & Aims: Genome editing technology has immense therapeutic potential and is likely to rapidly supplant contemporary gene addition approaches. Key advantages include the capacity to directly repair mutant loci with resultant recovery of phys
Externí odkaz:
https://doaj.org/article/81b618aa4be6420b93bda12009cd595b
Autor:
Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and
Externí odkaz:
https://doaj.org/article/841a0167145749b69b07423fda860202