Subversion of a family of antimicrobial proteins by Salmonella enterica

Autor: Roman G. Gerlach, Irene Wittmann, Lena Heinrich, Olaf Pinkenburg, Torben Meyer, Laura Elpers, Christiane Schmidt, Michael Hensel, Markus Schnare

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Salmonella enterica is a food-borne pathogen able to cause a wide spectrum of diseases ranging from mild gastroenteritis to systemic infections. During almost all stages of the infection process Salmonella is likely to be exposed to a wide variety of

Externí odkaz: https://doaj.org/article/a59efd2a4f5944ab9bfe9b1e78b8e226

Activation, control and T-bet+ B cell-mediated immune surveillance of endogenous retroviruses

Autor: Eileen Rauch, Timm Amendt, Aleksandra Lopez Krol, Fabian Lang, Vincent Linse, Michelle Hohmann, Ann-Christin Keim, Susanne Kreutzer, Kevin Kawengian, Malte Buchholz, Philipp Duschner, Saskia Grauer, Barbara Schnierle, Andreas Ruhl, Ingo Burtscher, Sonja Dehnert, Stephanie Paul, Markus Schnare, Andreas Kaufmann, Thomas Winkler, Magdalena Huber, Stefan Bauer, Philipp Yu

Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their role as anti-cancer immune targets or drivers of autoimmune disease. Here, we generated mouse-str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5461eb22ad2fae2863bc41d8bcbdabc5
https://doi.org/10.21203/rs.3.rs-2666493/v1

The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus.

Autor: Olaf Pinkenburg, Torben Meyer, Norbert Bannert, Steven Norley, Kathrin Bolte, Volker Czudai-Matwich, Susanne Herold, André Gessner, Markus Schnare

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156929 (2016)

In addition to their well-known antibacterial activity some antimicrobial peptides and proteins (AMPs) display also antiviral effects. A 27 aa peptide from the N-terminal part of human bactericidal/permeability-increasing protein (BPI) previously sho

Externí odkaz: https://doaj.org/article/8f84aa30cde24196a8d4163d7c9b99cc

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia

Autor: Stefan Bereswill, Ulrich Steinhoff, Mark Suter, Oliver H. Robak, Mathias W. Hornef, Catherine Chaput, Martin Witzenrath, Birgitt Gutbier, Hubertus Hochrein, Leif E. Sander, Veena Marathe, Katrin Reppe, Carsten J. Kirschning, Bastian Opitz, Jan Buer, Markus M. Heimesaat, Sandra Prepens, Andrey Kruglov, Pascal Schneider, Markus Schnare, Justus Ninnemann, Norbert Suttorp

Publikováno v: Infektiologie Update 2018; 26. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20181004-20181006; Wien; DOC18peg14 /20181008/
The Journal of clinical investigation, vol. 128, no. 8, pp. 3535-3545

Broad-spectrum antibiotics are widely used with patients in intensive care units (ICUs), many of whom develop hospital-acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. ae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2e598079311dbe5c35b8a0054d7202
https://pubmed.ncbi.nlm.nih.gov/30010618

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

Autor: Andreas Kaufmann, Leticia Quintanilla-Martinez, Markus Schnare, Silke Storsberg, Karolin Döhne, Stephanie Paul, Wolger Lübben, Michael Thanisch, Larissa Kolesnikova, Sonja Dehnert, Chengcong Cai, Philipp Yu, Barbara S. Schnierle, Olivia Prazeres da Costa, Sabrina Bettio, M. Nain, Janine Gebler, Luisa Neubrandt, Lisa Wiegand, Stephan Becker, Heike Slomka, Madlen Konert, Stefan Bauer

Publikováno v: Immunity. 37(5):867-879

SummaryThe genome of vertebrates contains endogenous retroviruses (ERVs) that are largely nonfunctional relicts of ancestral germline infection by exogenous retroviruses. However, in some mouse strains ERVs are actively involved in disease. Here we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791ab66a13a65354fe176c3c00185811