Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Markus, Schirle"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Lukas-Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philipp Couttet, Frederic Sigoillot, Jana Ziegelmüller, Anne-Christine Uldry, Wojciech Teodorowicz, Niko Schmiedeberg, Oliver Mühlemann, Jürgen Reinhardt
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113159- (2023)
Externí odkaz:
https://doaj.org/article/a17f69f34eb64c599e2fdcd86f226d38
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer
Externí odkaz:
https://doaj.org/article/e4c4de122bed46cdace434fd84397a5c
Autor:
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O. Frank, Matthew J. Hesse, Daniela Dankova, Jae-Geun Song, Megan Bruce-Smythe, Heidi Struble, Francisco J. Garcia, Scott M. Brittain, Andrew C. Kile, Lynn M. McGregor, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1702-1702 (2023)
Externí odkaz:
https://doaj.org/article/45f60932a33347c4abe0263c84aaeafc
Autor:
Ethan S. Toriki, James W. Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O. Frank, Matthew J. Hesse, Daniela Dankova, Jae-Geun Song, Megan Bruce-Smythe, Heidi Struble, Francisco J. Garcia, Scott M. Brittain, Andrew C. Kile, Lynn M. McGregor, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Publikováno v:
ACS Central Science. 9:915-926
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c2b9836c00807bb6ad517e9fb4b667b
https://doi.org/10.1021/acscentsci.2c01317
https://doi.org/10.1021/acscentsci.2c01317
Autor:
Angel Gonzalez-Valero, Audrey G. Reeves, Annika C. S. Page, Patrick J. Moon, Edward Miller, Katia Coulonval, Steven W. M. Crossley, Xiao Xie, Dan He, Patricia Z. Musacchio, Alec H. Christian, Jeffrey M. McKenna, Richard A. Lewis, Eric Fang, Dustin Dovala, Yipin Lu, Lynn M. McGregor, Markus Schirle, John A. Tallarico, Pierre P. Roger, F. Dean Toste, Christopher J. Chang
Publikováno v:
J Am Chem Soc
Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing functional protein sites and compounds for therapeutic development. However, the vast majority of ABPP methods for covalent drug discovery target highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58682786d527195267ba39692a00c91b
https://doi.org/10.1021/jacs.2c04039
https://doi.org/10.1021/jacs.2c04039
Autor:
Margaret L. Wong, Jason Murphy, Edmund Harrington, Carrie M. Gower, Rishi K. Jain, Markus Schirle, Jason R. Thomas
Publikováno v:
Proteome Science, Vol 15, Iss 1, Pp 1-8 (2017)
Abstract Background Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors have been successful
Externí odkaz:
https://doaj.org/article/c4c8f5ee411d4c839120d0e39b01c11a
Autor:
Patrick Moon, Charlotte M. Zammit, Qian Shao, Dustin Dovala, Lydia Boike, Nathaniel J. Henning, Mark Knapp, Jessica N. Spradlin, Carl C. Ward, Helene Wolleb, Daniel Fuller, Gabrielle Blake, Jason P. Murphy, Feng Wang, Yipin Lu, Stephanie A. Moquin, Laura Tandeske, Matthew J. Hesse, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, F. Dean Toste, Daniel K. Nomura
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87a50b5733f55cf44f9b43ee3e858a7
https://doi.org/10.1002/cbic.202300116
https://doi.org/10.1002/cbic.202300116
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
