Zobrazeno 1 - 10
of 403
pro vyhledávání: '"Markus, Müschen"'
Autor:
Adeleh Taghi Khani, Anil Kumar, Ashly Sanchez Ortiz, Kelly C. Radecki, Soraya Aramburo, Sung June Lee, Zunsong Hu, Behzad Damirchi, Mary Y. Lorenson, Xiwei Wu, Zhaohui Gu, William Stohl, Ignacio Sanz, Eric Meffre, Markus Müschen, Stephen J. Forman, Jean L. Koff, Ameae M. Walker, Srividya Swaminathan
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Malignant human B cells express autocrine prolactin (PRL), which has the potential to engage the long isoform and intermediate form of the PRL receptor to promote proliferation and/or survival.
Externí odkaz:
https://doaj.org/article/84ab9aaf43bd41779abbb7561b6c18e0
Autor:
Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun‐Wei Chen
Publikováno v:
Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)
Abstract Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics
Externí odkaz:
https://doaj.org/article/d8eb48a7527744de8eb5ea7136bf0bee
Autor:
Heather A. Ogana, Samantha Hurwitz, Chih-Lin Hsieh, Huimin Geng, Markus Müschen, Deepa Bhojwani, Mark A. Wolf, James Larocque, Michael R. Lieber, Yong Mi Kim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
As effective therapies for relapse and refractory B-cell acute lymphoblastic leukemia (B-ALL) remain problematic, novel therapeutic strategies are needed. Artemis is a key endonuclease in V(D)J recombination and nonhomologous end joining (NHEJ) of DN
Externí odkaz:
https://doaj.org/article/16124452d48a4bd1a4732545972846eb
Autor:
Ifat Geron, Angela Maria Savino, Hila Fishman, Noa Tal, John Brown, Virginia A. Turati, Chela James, Jolanda Sarno, Michal Hameiri-Grossman, Yu Nee Lee, Avigail Rein, Hillary Maniriho, Yehudit Birger, Anna Zemlyansky, Inna Muler, Kara L. Davis, Victoria Marcu-Malina, Nicole Mattson, Oren Parnas, Rabea Wagener, Ute Fischer, João T. Barata, Catriona H. M. Jamieson, Markus Müschen, Chun-Wei Chen, Arndt Borkhardt, Ilan Richard Kirsch, Arnon Nagler, Tariq Enver, Shai Izraeli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Activating mutations in Interleukin-7 receptor alpha (IL7Ra) have been reported in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) but its role in leukaemogenesis is not clear. Here, the authors show that activation of IL7Ra in primary human
Externí odkaz:
https://doaj.org/article/38d90d34ce264d24b343a4ddcc158487
Autor:
Franz Ketzer, Hend Abdelrasoul, Mona Vogel, Ralf Marienfeld, Markus Müschen, Hassan Jumaa, Thomas Wirth, Alexey Ushmorov
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract The D-type cyclins (CCND1, CCND2, and CCND3) in association with CDK4/6 are known drivers of cell cycle progression. We reported previously that inactivation of FOXO1 confers growth arrest and apoptosis in B-ALL, partially mediated by subseq
Externí odkaz:
https://doaj.org/article/cd3fcf0a0bbb43f9a95cf28d3dfc64d4
Autor:
Humberto Contreras-Trujillo, Jiya Eerdeng, Samir Akre, Du Jiang, Jorge Contreras, Basia Gala, Mary C. Vergel-Rodriguez, Yeachan Lee, Aparna Jorapur, Areen Andreasian, Lisa Harton, Charles S. Bramlett, Anna Nogalska, Gang Xiao, Jae-Woong Lee, Lai N. Chan, Markus Müschen, Akil A. Merchant, Rong Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
DNA barcoding is a promising technology for the simultaneous analysis of genetic and phenotypic heterogeneity. Here, the authors combine DNA barcoding and single-cell RNA-seq to study heterogeneity, progression and response to therapy in B-cell acute
Externí odkaz:
https://doaj.org/article/1cf0a0d2c96e4d41be8c44bd2d61e2d2
Autor:
Tsz-Yin Chan, Christina M. Egbert, Julia E. Maxson, Adam Siddiqui, Logan J. Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L. Pennington, Tsz-Ming Tsang, Madison Frey, Erik J. Soderblom, Huimin Geng, Markus Müschen, Tetyana V. Forostyan, Savannah Free, Gaelle Mercenne, Courtney J. Banks, Jonard Valdoz, Clifford J. Whatcott, Jason M. Foulks, David J. Bearss, Thomas O’Hare, David C. S. Huang, Kenneth A. Christensen, James Moody, Steven L. Warner, Jeffrey W. Tyner, Joshua L. Andersen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to T
Externí odkaz:
https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9
Autor:
Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
Externí odkaz:
https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
Autor:
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Current therapeutic approaches in chronic lymphocytic leukemia (CLL) focus on the suppression of PI3K/AKT signaling. Here, the authors show that CLL cells are vulnerable to hyperactivation of the PI3K/AKT signaling pathway and suggest this as a promi
Externí odkaz:
https://doaj.org/article/48da348450fd4d8c8348861c88888a7b
Autor:
Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism,
Externí odkaz:
https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9