Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Markus, Hartl"'
Autor:
Velina S. Atanasova, Crhistian de Jesus Cardona, Václav Hejret, Andreas Tiefenbacher, Theresia Mair, Loan Tran, Janette Pfneissl, Kristina Draganić, Carina Binder, Julijan Kabiljo, Janik Clement, Katharina Woeran, Barbara Neudert, Sabrina Wohlhaupter, Astrid Haase, Sandra Domazet, Markus Hengstschläger, Markus Mitterhauser, Leonhard Müllauer, Boris Tichý, Michael Bergmann, Gabriele Schweikert, Markus Hartl, Helmut Dolznig, Gerda Egger
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1391-1419 (2023)
Background & Aims: Patient-derived organoid cancer models are generated from epithelial tumor cells and reflect tumor characteristics. However, they lack the complexity of the tumor microenvironment, which is a key driver of tumorigenesis and therapy
Externí odkaz:
https://doaj.org/article/4731d5078fae4db69082355f0d4fbdc9
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Quantitative proteomics has become an increasingly prominent tool in the study of life sciences. A substantial hurdle for many biologists are, however, the intricacies involved in the associated high throughput data analysis. Resu
Externí odkaz:
https://doaj.org/article/c52e1ce3c43b45e59a6e49e428194612
Autor:
Leonie I. Weber, Markus Hartl
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The MYC oncoprotein functions as a master regulator of cellular transcription and executes non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby interacting with multiple proteins. MYC is required for fundamental ce
Externí odkaz:
https://doaj.org/article/092dc9ecb206402fa2019ade7d35702d
Autor:
Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara, Christian Seiser
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010376 (2022)
The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are available, these drugs do not allow a comprehensive understanding of individual HDAC function, o
Externí odkaz:
https://doaj.org/article/c86be04b9ac647019e3b6f55aae8c7bf
Autor:
Marion Lechable, Xuechen Tang, Stefan Siebert, Angelika Feldbacher, Monica L. Fernández-Quintero, Kathrin Breuker, Celina E. Juliano, Klaus R. Liedl, Bert Hobmayer, Markus Hartl
Publikováno v:
Cells, Vol 12, Iss 9, p 1265 (2023)
The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance. Myc interacts
Externí odkaz:
https://doaj.org/article/1b7c8b398acb43f889246597f843760b
Autor:
Berenice Ziegler, Irene Yiallouros, Benjamin Trageser, Sumit Kumar, Moritz Mercker, Svenja Kling, Maike Fath, Uwe Warnken, Martina Schnölzer, Thomas W. Holstein, Markus Hartl, Anna Marciniak-Czochra, Jörg Stetefeld, Walter Stöcker, Suat Özbek
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background The Hydra head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling th
Externí odkaz:
https://doaj.org/article/5576cb9a33f145bf9dc87ff3ebb7a844
Publikováno v:
Molecular Oncology, Vol 14, Iss 3, Pp 625-644 (2020)
The MYC protein is a transcription factor with oncogenic potential controlling fundamental cellular processes such as cell proliferation, metabolism, differentiation, and apoptosis. The MYC gene is a major cancer driver, and elevated MYC protein leve
Externí odkaz:
https://doaj.org/article/a684b1e0e426482c97d9388f1ea806e0
Autor:
Onur Temocin, Dominik Regele, Marc Sathianathan, Christa Überbacher, Markus Hartl, Frank Edenhofer, Dirk Meyer
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102522- (2021)
MNX1 encodes a homeobox transcription factor with conserved embryonic requirements in spinal motor neuron formation and pancreatic beta-cell differentiation. Mutations in MNX1 are associated with dominantly inherited Currarino syndrome and neonatal d
Externí odkaz:
https://doaj.org/article/599a2231c02a4322ac03572321b83c70
Autor:
Maria Velkova, Nicola Silva, Maria Rosaria Dello Stritto, Alexander Schleiffer, Pierre Barraud, Markus Hartl, Verena Jantsch
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009663 (2021)
Homologous recombination is a high-fidelity repair pathway for DNA double-strand breaks employed during both mitotic and meiotic cell divisions. Such repair can lead to genetic exchange, originating from crossover (CO) generation. In mitosis, COs are
Externí odkaz:
https://doaj.org/article/56b6564b61ed487d9aea33eb522767d6
Autor:
Alexander Mödlhammer, Sandra Pfurtscheller, Andreas Feichtner, Markus Hartl, Rainer Schneider
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal rearrange
Externí odkaz:
https://doaj.org/article/39dabf86ccb3473f82ec8aac7c939559