Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Markus, Hafner"'
Autor:
Kyung-Won Min, Myung Hyun Jo, Minseok Song, Ji Won Lee, Min Ji Shim, Kyungmin Kim, Hyun Bong Park, Shinwon Ha, Hyejin Mun, Ahsan Polash, Markus Hafner, Jung-Hyun Cho, Dongsan Kim, Ji-Hoon Jeong, Seungbeom Ko, Sungchul Hohng, Sung-Ung Kang, Je-Hyun Yoon
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-15 (2024)
ABSTRACTAlthough Argonaute (AGO) proteins have been the focus of microRNA (miRNA) studies, we observed AGO-free mature miRNAs directly interacting with RNA-binding proteins, implying the sophisticated nature of fine-tuning gene regulation by miRNAs.
Externí odkaz:
https://doaj.org/article/2031b122a0b248eea1c5236fa50038ff
Autor:
Miriam Cipullo, Genís Valentín Gesé, Shreekara Gopalakrishna, Annika Krueger, Vivian Lobo, Maria A. Pirozhkova, James Marks, Petra Páleníková, Dmitrii Shiriaev, Yong Liu, Jelena Misic, Yu Cai, Minh Duc Nguyen, Abubakar Abdelbagi, Xinping Li, Michal Minczuk, Markus Hafner, Daniel Benhalevy, Aishe A. Sarshad, Ilian Atanassov, B. Martin Hällberg, Joanna Rorbach
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs. The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors. Among these factors, GTP-binding proteins (GTPBPs) play impo
Externí odkaz:
https://doaj.org/article/7e993f34f7d84d7d9dd49ff3b7ab5aba
Autor:
Andrew J. Heindel, Jeffrey W. Brulet, Xiantao Wang, Michael W. Founds, Adam H. Libby, Dina L. Bai, Michael C. Lemke, David M. Leace, Thurl E. Harris, Markus Hafner, Ku-Lung Hsu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells. The ability to measure RBP activity at
Externí odkaz:
https://doaj.org/article/04e8d79101f84503b966141edfd09c6e
Autor:
Arwa Fallatah, Dimitrios G. Anastasakis, Amirhossein Manzourolajdad, Pooja Sharma, Xiantao Wang, Alexis Jacob, Sarah Alsharif, Ahmed Elgerbi, Pierre A. Coulombe, Markus Hafner, Byung Min Chung
Publikováno v:
BMC Molecular and Cell Biology, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes cell proliferation an
Externí odkaz:
https://doaj.org/article/1d2aae9ceeed43c083f5ac31343b76dc
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0297262 (2024)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the innate immune machinery through multiple viral proteins, including nonstructural protein 1 (NSP1). While NSP1 is known to suppress translation of host mRNAs, the mechanisms u
Externí odkaz:
https://doaj.org/article/a1cbe667de2442479febe318661cba5f
Autor:
Taeyun A. Lee, Heonjong Han, Ahsan Polash, Seok Keun Cho, Ji Won Lee, Eun A. Ra, Eunhye Lee, Areum Park, Sujin Kang, Junhee L. Choi, Ji Hyun Kim, Ji Eun Lee, Kyung-Won Min, Seong Wook Yang, Markus Hafner, Insuk Lee, Je-Hyun Yoon, Sungwook Lee, Boyoun Park
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The nucleolus is the traditional site for ribosomal RNA biogenesis. Here, the authors find that the nucleolus is a site of inflammatory pre-mRNA turnover and elucidated how immune homeostasis can be maintained by controlling inflammatory gene express
Externí odkaz:
https://doaj.org/article/3900adf1879d4f5d8d92fd2ebe8a5501
Autor:
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Raj Chari, Myriam Gorospe, Curtis C. Harris, Mirit I. Aladjem, Munira A. Basrai, Markus Hafner, Ashish Lal
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112260- (2023)
Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Mat
Externí odkaz:
https://doaj.org/article/a88f2d3b066a45a5bbb59f4426f60a4b
Autor:
Xiaojing Yang, Jina Nanayakkara, Duncan Claypool, Sadegh Saghafinia, Justin J. M. Wong, Minqi Xu, Xiantao Wang, Christopher J. B. Nicol, Iacovos P. Michael, Markus Hafner, Xiaolong Yang, Neil Renwick
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375
Externí odkaz:
https://doaj.org/article/72661e3a38244d87bdf71ce5806af456
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on ge
Externí odkaz:
https://doaj.org/article/81af71b108cf49c58d849e413ef24f8d
Autor:
Markus Sauer, Stefan A. Juranek, James Marks, Alessio De Magis, Hinke G. Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslat
Externí odkaz:
https://doaj.org/article/c487ca0e9f33481f9ed1636cdf7e8cc9